FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088892219> ?p ?o ?g. }

• W2088892219 endingPage "548" @default.
• W2088892219 startingPage "548" @default.
• W2088892219 abstract "Conclusion: Patients with vascular events are those at highest risk for future cardiovascular death, myocardial infarction, and stroke. Summary: Clinical trials of pharmacologic agents in patients with atherosclerosis often report event rates in placebo groups lower than projected (Bhatt DL, N Engl J Med 2009;361:2330-41; Sacco RL, N Engl J Med 2008;359:1238-51; and Topol EG, Lancet 2010;376:517-23). To increase likelihood that a particular therapy might demonstrate benefit, it is important to identify patients to participate in trials who are at high risk for cardiovascular events. The REACH (Reduction of Atherothrombosis for Continued Health) Registry consists of patients with various manifestations of atherosclerosis varying from asymptomatic adults with risk factors to those with stable atherosclerosis to those with prior ischemic events. In this study the authors analyze the effects of prior ischemic events, polyvascular disease, and diabetes mellitus with respect to future cardiovascular risk. Patients in the REACH Registry were followed for up to 4 years. Patients were from 3647 centers in 29 countries enrolled between 2003 and 2004 and followed up until 2008. The primary end point was a composite of cardiovascular deaths, myocardial infarction, and stroke. Main outcome measures were rates of cardiovascular death, myocardial infarction, and stroke. There were 45,227 patients included in the 4-year analysis. During follow-up, 5481 patients experienced at least one event; 2315 cardiovascular deaths, 1228 myocardial infarctions, 1898 strokes, and 40 cases where myocardial infarction and stroke occurred on the same day. Those with a history of ischemic events at baseline (n = 21,890) had the highest rate of subsequent ischemic events (18.3%: 95% confidence interval [CI], 17.4%- 19.1%). Patients with stable coronary, cerebrovascular, or peripheral artery disease (n = 15,264) had a lower risk (12.2%; 95% CI, 11.4%-12.9%). Patients with risk factors without established atherothrombosis (n = 8073) had the lowest risk (9.1%; 95% CI, 8.3%-9.9%; P < .001 for all comparisons). In multivariable modeling diabetes (hazard ratio [HR], 1.44; P < .001), an ischemic event in the previous year (HR 1.71; P < .01), and polyvascular disease (HR, 1.99; P < .001) all were associated with increased risk of the primary end point. Comment: The data indicate polyvascular disease and a history of ischemic events, particularly in the last year, are strongly associated with cardiovascular death, myocardial infarction, and stroke. Many vascular surgical patients would fall in to the high-risk groups. This perhaps explains, in part, the high mortality rates of vascular surgical patients over time and somewhat cynically may explain why vascular surgery patients tend to be “repeat customers.” Once a patient with vascular disease has a cardiovascular event they are much more likely to have additional events." @default.
• W2088892219 created "2016-06-24" @default.
• W2088892219 creator A5010571732 @default.
• W2088892219 creator A5049266332 @default.
• W2088892219 creator A5074241426 @default.
• W2088892219 date "2011-02-01" @default.
• W2088892219 modified "2023-09-28" @default.
• W2088892219 title "Comparative Determinants of 4-Year Cardiovascular Event Rates in Stable Outpatients at Risk of or With Atherothrombosis" @default.
• W2088892219 cites W1972136146 @default.
• W2088892219 cites W1983492971 @default.
• W2088892219 cites W1987941106 @default.
• W2088892219 cites W1992190937 @default.
• W2088892219 cites W1994822962 @default.
• W2088892219 cites W2013009184 @default.
• W2088892219 cites W2031799897 @default.
• W2088892219 cites W2032619862 @default.
• W2088892219 cites W2032783186 @default.
• W2088892219 cites W2034690624 @default.
• W2088892219 cites W2069468497 @default.
• W2088892219 cites W2071559757 @default.
• W2088892219 cites W2071686230 @default.
• W2088892219 cites W2087410266 @default.
• W2088892219 cites W2100209149 @default.
• W2088892219 cites W2112222692 @default.
• W2088892219 cites W2135989027 @default.
• W2088892219 cites W2136228924 @default.
• W2088892219 cites W2157184686 @default.
• W2088892219 cites W2331274940 @default.
• W2088892219 cites W2397867274 @default.
• W2088892219 cites W3145336813 @default.
• W2088892219 doi "https://doi.org/10.1016/j.jvs.2010.12.013" @default.
• W2088892219 hasPublicationYear "2011" @default.
• W2088892219 type Work @default.
• W2088892219 sameAs 2088892219 @default.
• W2088892219 citedByCount "3" @default.
• W2088892219 countsByYear W20888922192012 @default.
• W2088892219 countsByYear W20888922192019 @default.
• W2088892219 countsByYear W20888922192021 @default.
• W2088892219 crossrefType "journal-article" @default.
• W2088892219 hasAuthorship W2088892219A5010571732 @default.
• W2088892219 hasAuthorship W2088892219A5049266332 @default.
• W2088892219 hasAuthorship W2088892219A5074241426 @default.
• W2088892219 hasBestOaLocation W20888922191 @default.
• W2088892219 hasConcept C71924100 @default.
• W2088892219 hasConcept C74909509 @default.
• W2088892219 hasConceptScore W2088892219C71924100 @default.
• W2088892219 hasConceptScore W2088892219C74909509 @default.
• W2088892219 hasIssue "2" @default.
• W2088892219 hasLocation W20888922191 @default.
• W2088892219 hasOpenAccess W2088892219 @default.
• W2088892219 hasPrimaryLocation W20888922191 @default.
• W2088892219 hasVolume "53" @default.
• W2088892219 isParatext "false" @default.
• W2088892219 isRetracted "false" @default.
• W2088892219 magId "2088892219" @default.
• W2088892219 workType "article" @default.