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• W2088892340 abstract "Abstract. The incidence of stroke on cranial computed tomography (CT) and change in echocardiographic vegetation area was prospectively compared in a preliminary observational study involving nine patients with infective endocarditis randomized to either low-dose aspirin (75 mg d-1, Group I, n = 4) or no aspirin (Group II, n = 5). Two symptomatic cerebral infarcts and one myocardial infarct occurred in the controls, compared to no events in patients on aspirin during a total observation period of 343 d (range 28–49 d). The mean vegetation area decreased in the aspirin group (mean change = -0.24 cm2), compared to an increase in controls (mean change = ± 0.35 cm2). The platelet half-life (normal range 5–6 d), which was measured using Indium-111 radiolabelling, tended to be lower in Group II (4.6 ± 0.2 vs. 3.9 ± 0.5 d). No side-effects or complications attributable to aspirin were observed. A possible role for adjunctive aspirin therapy in the prevention of embolic complications in infective endocarditis is suggested, and warrants further study." @default.
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• W2088892340 date "1992-05-01" @default.
• W2088892340 modified "2023-09-27" @default.
• W2088892340 title "Aspirin to prevent growth of vegetations and cerebral emboli in infective endocarditis" @default.
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• W2088892340 doi "https://doi.org/10.1111/j.1365-2796.1992.tb00971.x" @default.
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