FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088892403> ?p ?o ?g. }

• W2088892403 endingPage "718" @default.
• W2088892403 startingPage "705" @default.
• W2088892403 abstract "Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling network required to accomplish all cellular functions. Understanding when, why and how a gene is expressed has now become a necessity toward identifying all the regulatory pathways that mediate cellular processes such as differentiation, migration, replication, DNA repair and apoptosis. Regulation of gene transcription is a process that is primarily under the influence of nuclear-located transcription factors. Consequently, identifying which protein activates or represses a specific gene is a prerequisite for understanding cell fate and function. The current state of, and recent advances in, transcriptional regulation approaches are reviewed here, with special emphasis on new technologies required when probing for DNA-protein interactions. This review explores different strategies aimed at identifying both the regulatory sequences of any given gene and the trans-acting regulatory factors that recognize these elements as their target sites in the nucleus. Ongoing developments in the fields of nanotechnology, RNA silencing and protein modeling toward the investigation of DNA-protein interactions and their relevance in the battle against cancer are discussed." @default.
• W2088892403 created "2016-06-24" @default.
• W2088892403 creator A5020814828 @default.
• W2088892403 creator A5062286994 @default.
• W2088892403 date "2005-10-01" @default.
• W2088892403 modified "2023-10-12" @default.
• W2088892403 title "Regulation of gene expression: probing DNA–protein interactions<i>in vivo</i>and<i>in vitro</i>" @default.
• W2088892403 cites W1485322204 @default.
• W2088892403 cites W1492185019 @default.
• W2088892403 cites W1510613202 @default.
• W2088892403 cites W1519057123 @default.
• W2088892403 cites W1531234455 @default.
• W2088892403 cites W1531710418 @default.
• W2088892403 cites W1551689925 @default.
• W2088892403 cites W1587050401 @default.
• W2088892403 cites W1604428153 @default.
• W2088892403 cites W1605692660 @default.
• W2088892403 cites W1616824889 @default.
• W2088892403 cites W163073635 @default.
• W2088892403 cites W1748937346 @default.
• W2088892403 cites W182731114 @default.
• W2088892403 cites W1875831555 @default.
• W2088892403 cites W1875933026 @default.
• W2088892403 cites W1970592466 @default.
• W2088892403 cites W1972398442 @default.
• W2088892403 cites W1974279777 @default.
• W2088892403 cites W1975036436 @default.
• W2088892403 cites W1975749637 @default.
• W2088892403 cites W1980265302 @default.
• W2088892403 cites W1983237216 @default.
• W2088892403 cites W1986072777 @default.
• W2088892403 cites W1986501756 @default.
• W2088892403 cites W1986941949 @default.
• W2088892403 cites W1987122345 @default.
• W2088892403 cites W1988298211 @default.
• W2088892403 cites W1989080074 @default.
• W2088892403 cites W1989195046 @default.
• W2088892403 cites W1992679299 @default.
• W2088892403 cites W1995337879 @default.
• W2088892403 cites W1996642589 @default.
• W2088892403 cites W2001375090 @default.
• W2088892403 cites W2003425522 @default.
• W2088892403 cites W2005792315 @default.
• W2088892403 cites W2006892956 @default.
• W2088892403 cites W2009659265 @default.
• W2088892403 cites W2014354647 @default.
• W2088892403 cites W2017535650 @default.
• W2088892403 cites W2019616754 @default.
• W2088892403 cites W2024156097 @default.
• W2088892403 cites W2025011613 @default.
• W2088892403 cites W2026882865 @default.
• W2088892403 cites W2028431632 @default.
• W2088892403 cites W2029255146 @default.
• W2088892403 cites W2030855909 @default.
• W2088892403 cites W2031753048 @default.
• W2088892403 cites W2036347938 @default.
• W2088892403 cites W2038077039 @default.
• W2088892403 cites W2038637564 @default.
• W2088892403 cites W2041797639 @default.
• W2088892403 cites W2042745425 @default.
• W2088892403 cites W2043009832 @default.
• W2088892403 cites W2043457799 @default.
• W2088892403 cites W2045101135 @default.
• W2088892403 cites W2048379517 @default.
• W2088892403 cites W2049055414 @default.
• W2088892403 cites W2049630658 @default.
• W2088892403 cites W2049869291 @default.
• W2088892403 cites W2051395442 @default.
• W2088892403 cites W2053833990 @default.
• W2088892403 cites W2056769699 @default.
• W2088892403 cites W2057050252 @default.
• W2088892403 cites W2061879992 @default.
• W2088892403 cites W2063083144 @default.
• W2088892403 cites W2064129352 @default.
• W2088892403 cites W2069601286 @default.
• W2088892403 cites W2070838947 @default.
• W2088892403 cites W2076446466 @default.
• W2088892403 cites W2079461029 @default.
• W2088892403 cites W2084620487 @default.
• W2088892403 cites W2085045185 @default.
• W2088892403 cites W2089966391 @default.
• W2088892403 cites W2091986668 @default.
• W2088892403 cites W2092770422 @default.
• W2088892403 cites W2095194341 @default.
• W2088892403 cites W2095224181 @default.
• W2088892403 cites W2095911393 @default.
• W2088892403 cites W2096286842 @default.
• W2088892403 cites W2097794242 @default.
• W2088892403 cites W2098586771 @default.
• W2088892403 cites W2101706357 @default.
• W2088892403 cites W2109217888 @default.
• W2088892403 cites W2115526120 @default.
• W2088892403 cites W2117555142 @default.
• W2088892403 cites W2118146357 @default.
• W2088892403 cites W2120006551 @default.
• W2088892403 cites W2120731177 @default.
• W2088892403 cites W2122893035 @default.
• W2088892403 cites W2123812291 @default.

• next