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• W2088892561 startingPage "4290" @default.
• W2088892561 abstract "An environmentally safe method for the synthesis of novel substituted 2-(5-(4-aryl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-3-alkylpyrazine, 1-(5-(4-aryl)-3-(3-alkylpyrazin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone and 5-(4-aryl)-3-(3-alkylpyrazin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide via reactions of (E)-3-aryl-1-(3-alkyl-2-pyrazinyl)-2-propenones with phenyl hydrazine hydrochloride, hydrazine monohydrate and thiosemicarbazide respectively is reported. The reactions were carried out using sodium acetate–aqueous acetic acid solution at room temperature, under ultrasound irradiation (US). As compared to conventional methods, the advantages of the US method encompass milder conditions, operational simplicity, higher yield up to ≈93%, safety and environmentally friendly protocol. The synthesized compounds were evaluated in vitro for their antibacterial activities against Gram-positive and negative strains. Compounds 4a–4l showed 29–67% antioxidant activities, as determined through a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical method. All synthesized compounds were screened for their DNA binding activities using a spectrofluorometer, where those containing halogens exhibited a significant potential (up to 570 ng mL−1) due to the corresponding intercalation and groove binding mechanisms." @default.
• W2088892561 created "2016-06-24" @default.
• W2088892561 creator A5063330587 @default.
• W2088892561 creator A5070308963 @default.
• W2088892561 date "2014-05-28" @default.
• W2088892561 modified "2023-09-23" @default.
• W2088892561 title "Synthesis, characterization, antibacterial, antioxidant, DNA binding and SAR study of a novel pyrazine moiety bearing 2-pyrazoline derivatives" @default.
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• W2088892561 doi "https://doi.org/10.1039/c4nj00594e" @default.
• W2088892561 hasPublicationYear "2014" @default.
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