FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088893549> ?p ?o ?g. }

• W2088893549 endingPage "129" @default.
• W2088893549 startingPage "125" @default.
• W2088893549 abstract "The merozoite surface protein-1 (MSP-1) is a relatively abundant protein which has been found in all Plasmodium species examined [1,2]. MSP-1 is synthesized as a high molecular mass ( 200 kDa) precursor protein which is proteolytically processed into smaller fragments. Proteolytic processing of MSP-1 is a two-step procedure characterized by primary and secondary processing events [3]. Primary processing occurs at, or just before, terminal merozoite differentiation and release and results in the formation of a noncovalent polypeptide complex with fragments of approximately 83, 30, 38 and 42 kDa [4]. The 42 kDa C-terminal fragment is further processed to 33 and 19 kDa fragments at the time of merozoite invasion [5]. This secondary processing is catalyzed by a Ca-activated serine protease which results in the shedding of a soluble MSP-1 complex [6]. The remaining glycosyl-phosphatidylinositol-anchored 19 kDa fragment [7] contains two epidermal growth factor-like modules [8] and is carried into the erythrocyte upon merozoite invasion [9]. Comparison of the MSP-1 sequence from P. berghei with other rodent parasite MSP-1 sequences [10–12] revealed four major interspecies variable regions, or blocks (Jennings et al., in preparation). The first (i.e., most N-terminal) of these variable blocks was cloned from a lgt11 cDNA expression library screened with two different mAbs against PbMSP-1 [13]. The mAbs, designated as mAb-F4.4 and mAb-L1.6, were generated from mice immune to P. berghei [14]. Variable block 1 (VB1) contains seven degenerate Abbre6iations: LT-B, B subunit of E. coli labile toxin; MSP1, merozoite surface protein-1; VB1, variable block 1. * Corresponding author. Tel.: +1 504 5842507; fax: +1 504 5996686; e-mail: wiser@mailhost.tcs.tulane.edu 1 Present address: Department of Biology, City College of San Francisco, San Francisco, CA 94112, USA. 2 Present address: Michigan Department of Community Health, P.O. Box 30035, Lansing, MI 48909, USA." @default.
• W2088893549 created "2016-06-24" @default.
• W2088893549 creator A5007270669 @default.
• W2088893549 creator A5021484154 @default.
• W2088893549 creator A5078702117 @default.
• W2088893549 date "1997-03-01" @default.
• W2088893549 modified "2023-09-24" @default.
• W2088893549 title "An additional primary proteolytic processing site in merozoite surface protein-1 of Plasmodium berghei" @default.
• W2088893549 cites W1565403266 @default.
• W2088893549 cites W1962127316 @default.
• W2088893549 cites W1972742840 @default.
• W2088893549 cites W1974976084 @default.
• W2088893549 cites W1978153917 @default.
• W2088893549 cites W1985469117 @default.
• W2088893549 cites W1990948693 @default.
• W2088893549 cites W2009149430 @default.
• W2088893549 cites W2036875255 @default.
• W2088893549 cites W2038322646 @default.
• W2088893549 cites W2040082954 @default.
• W2088893549 cites W2044462082 @default.
• W2088893549 cites W2050101049 @default.
• W2088893549 cites W2059662414 @default.
• W2088893549 cites W2059766541 @default.
• W2088893549 cites W2062519861 @default.
• W2088893549 cites W2067620951 @default.
• W2088893549 cites W2072900960 @default.
• W2088893549 cites W2130531071 @default.
• W2088893549 cites W2168138163 @default.
• W2088893549 cites W2414773294 @default.
• W2088893549 cites W2416238667 @default.
• W2088893549 doi "https://doi.org/10.1016/s0166-6851(96)02811-3" @default.
• W2088893549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9108554" @default.
• W2088893549 hasPublicationYear "1997" @default.
• W2088893549 type Work @default.
• W2088893549 sameAs 2088893549 @default.
• W2088893549 citedByCount "3" @default.
• W2088893549 crossrefType "journal-article" @default.
• W2088893549 hasAuthorship W2088893549A5007270669 @default.
• W2088893549 hasAuthorship W2088893549A5021484154 @default.
• W2088893549 hasAuthorship W2088893549A5078702117 @default.
• W2088893549 hasBestOaLocation W20888935492 @default.
• W2088893549 hasConcept C136764020 @default.
• W2088893549 hasConcept C159047783 @default.
• W2088893549 hasConcept C203014093 @default.
• W2088893549 hasConcept C2777023991 @default.
• W2088893549 hasConcept C2777237215 @default.
• W2088893549 hasConcept C2778048844 @default.
• W2088893549 hasConcept C2778371730 @default.
• W2088893549 hasConcept C2778675580 @default.
• W2088893549 hasConcept C2781034427 @default.
• W2088893549 hasConcept C3019232848 @default.
• W2088893549 hasConcept C41008148 @default.
• W2088893549 hasConcept C55493867 @default.
• W2088893549 hasConcept C71928629 @default.
• W2088893549 hasConcept C86803240 @default.
• W2088893549 hasConceptScore W2088893549C136764020 @default.
• W2088893549 hasConceptScore W2088893549C159047783 @default.
• W2088893549 hasConceptScore W2088893549C203014093 @default.
• W2088893549 hasConceptScore W2088893549C2777023991 @default.
• W2088893549 hasConceptScore W2088893549C2777237215 @default.
• W2088893549 hasConceptScore W2088893549C2778048844 @default.
• W2088893549 hasConceptScore W2088893549C2778371730 @default.
• W2088893549 hasConceptScore W2088893549C2778675580 @default.
• W2088893549 hasConceptScore W2088893549C2781034427 @default.
• W2088893549 hasConceptScore W2088893549C3019232848 @default.
• W2088893549 hasConceptScore W2088893549C41008148 @default.
• W2088893549 hasConceptScore W2088893549C55493867 @default.
• W2088893549 hasConceptScore W2088893549C71928629 @default.
• W2088893549 hasConceptScore W2088893549C86803240 @default.
• W2088893549 hasIssue "1" @default.
• W2088893549 hasLocation W20888935491 @default.
• W2088893549 hasLocation W20888935492 @default.
• W2088893549 hasLocation W20888935493 @default.
• W2088893549 hasOpenAccess W2088893549 @default.
• W2088893549 hasPrimaryLocation W20888935491 @default.
• W2088893549 hasRelatedWork W1509045004 @default.
• W2088893549 hasRelatedWork W1987258585 @default.
• W2088893549 hasRelatedWork W2015243764 @default.
• W2088893549 hasRelatedWork W2028898290 @default.
• W2088893549 hasRelatedWork W2117691144 @default.
• W2088893549 hasRelatedWork W2418748945 @default.
• W2088893549 hasRelatedWork W2985440267 @default.
• W2088893549 hasRelatedWork W3182705979 @default.
• W2088893549 hasRelatedWork W3189283500 @default.
• W2088893549 hasRelatedWork W4292730579 @default.
• W2088893549 hasVolume "85" @default.
• W2088893549 isParatext "false" @default.
• W2088893549 isRetracted "false" @default.
• W2088893549 magId "2088893549" @default.
• W2088893549 workType "article" @default.