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- W2088894802 abstract "The transition of stem cells from quiescence to proliferation enables tissues to self-repair. The signaling mechanisms driving these stem-cell-status decisions are still unclear. Ca2+ and the extracellular signal-regulated kinase (Erk1/2) are two signaling pathways that have the potential to coordinate multiple signals to promote a specific cellular response. They both play important roles during nervous system development but their roles during spinal cord and muscle regeneration are not fully deciphered. Here we show in Xenopus laevis larvae that both Ca2+ and Erk1/2 signaling pathways are activated after tail amputation. In response to injury, we find that Erk1/2 signaling is activated in neural and muscle stem cells and is necessary for spinal cord and skeletal muscle regeneration. Finally, we show in vivo that Erk1/2 activity is necessary for an injury-induced increase in intracellular store-dependent Ca2+ dynamics in skeletal muscle-associated tissues but that in spinal cord, injury increases Ca2+ influx-dependent Ca2+ activity independent of Erk1/2 signaling. This study suggests that precise temporal and tissue-specific activation of Ca2+ and Erk1/2 pathways is essential for regulating spinal cord and muscle regeneration." @default.
- W2088894802 created "2016-06-24" @default.
- W2088894802 creator A5002708584 @default.
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- W2088894802 date "1999-11-01" @default.
- W2088894802 modified "2023-09-27" @default.
- W2088894802 title "New Insights into the Control of MAP Kinase Pathways" @default.
- W2088894802 cites W1479869774 @default.
- W2088894802 cites W1494491432 @default.
- W2088894802 cites W1495466419 @default.
- W2088894802 cites W1497443740 @default.
- W2088894802 cites W1498760971 @default.
- W2088894802 cites W1516078935 @default.
- W2088894802 cites W1526528713 @default.
- W2088894802 cites W1532900970 @default.
- W2088894802 cites W1544401280 @default.
- W2088894802 cites W1555409791 @default.
- W2088894802 cites W1566737177 @default.
- W2088894802 cites W1572590697 @default.
- W2088894802 cites W1597498191 @default.
- W2088894802 cites W165372149 @default.
- W2088894802 cites W1675086682 @default.
- W2088894802 cites W1679419992 @default.
- W2088894802 cites W1766090917 @default.
- W2088894802 cites W1769585641 @default.
- W2088894802 cites W1774418672 @default.
- W2088894802 cites W1844240163 @default.
- W2088894802 cites W1848239201 @default.
- W2088894802 cites W1885709862 @default.
- W2088894802 cites W1915240707 @default.
- W2088894802 cites W1921176196 @default.
- W2088894802 cites W1962270087 @default.
- W2088894802 cites W1963817582 @default.
- W2088894802 cites W1967218150 @default.
- W2088894802 cites W1967780354 @default.
- W2088894802 cites W1968606500 @default.
- W2088894802 cites W1969288614 @default.
- W2088894802 cites W1969759973 @default.
- W2088894802 cites W1969785844 @default.
- W2088894802 cites W1970328692 @default.
- W2088894802 cites W1971915141 @default.
- W2088894802 cites W1972172786 @default.
- W2088894802 cites W1972812612 @default.
- W2088894802 cites W1974353473 @default.
- W2088894802 cites W1974585421 @default.
- W2088894802 cites W1976462601 @default.
- W2088894802 cites W1976849281 @default.
- W2088894802 cites W1977472414 @default.
- W2088894802 cites W1980095812 @default.
- W2088894802 cites W1981493299 @default.
- W2088894802 cites W1982499214 @default.
- W2088894802 cites W1983475354 @default.
- W2088894802 cites W1984037275 @default.
- W2088894802 cites W1984903682 @default.
- W2088894802 cites W1985065252 @default.
- W2088894802 cites W1991972495 @default.
- W2088894802 cites W1992494265 @default.
- W2088894802 cites W1992610215 @default.
- W2088894802 cites W1993643447 @default.
- W2088894802 cites W1994762541 @default.
- W2088894802 cites W1994954884 @default.
- W2088894802 cites W1994957003 @default.
- W2088894802 cites W1994986373 @default.
- W2088894802 cites W1995035611 @default.
- W2088894802 cites W1995819749 @default.
- W2088894802 cites W1999788892 @default.
- W2088894802 cites W2000217470 @default.
- W2088894802 cites W2001399809 @default.
- W2088894802 cites W2002303369 @default.
- W2088894802 cites W2003940624 @default.
- W2088894802 cites W2006420079 @default.
- W2088894802 cites W2008812258 @default.
- W2088894802 cites W2008855387 @default.
- W2088894802 cites W2009338295 @default.
- W2088894802 cites W2009445851 @default.
- W2088894802 cites W2010489503 @default.
- W2088894802 cites W2010955929 @default.
- W2088894802 cites W2011184275 @default.
- W2088894802 cites W2011312875 @default.
- W2088894802 cites W2015802741 @default.
- W2088894802 cites W2016610889 @default.
- W2088894802 cites W2018221682 @default.
- W2088894802 cites W2018936093 @default.
- W2088894802 cites W2026951979 @default.
- W2088894802 cites W2027624022 @default.
- W2088894802 cites W2029149519 @default.
- W2088894802 cites W2030196438 @default.
- W2088894802 cites W2030284600 @default.
- W2088894802 cites W2030383157 @default.
- W2088894802 cites W2032731042 @default.
- W2088894802 cites W2033421786 @default.
- W2088894802 cites W2035764871 @default.
- W2088894802 cites W2035936653 @default.