FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088895515> ?p ?o ?g. }

• W2088895515 endingPage "371" @default.
• W2088895515 startingPage "361" @default.
• W2088895515 abstract "Targeting adenoviral vectors for cystic fibrosis gene therapy to the human airways with minimal exposure to alveoli would avoid adverse reactions and maximize response. At present, to deliver gene therapy vectors, large volumes of fluid are instilled or nebulized as aerosols. Either approach would likely cause alveolar exposure and increases the potential for side effects. We describe a coarse spray delivery device that precisely and reproducibly delivers the viral vector to the human airways to treat a small region of the airways for clinical trials. An endoscopic washing pipe (Olympus) that can be inserted into the channel of a bronchoscope was used. To minimize the escape of the therapeutic material downstream from the site of administration, we restricted the volume delivered to <150 microl (to prevent bulk flow), and used large droplets. Their high velocity further enhanced the probability of impaction in the vicinity of the nozzle. A pneumatic dosing system (Kahnetics) was used to reproducibly deliver the spray. The droplet size distribution was determined by laser diffraction and confirmed by cascade impaction: 190-microm volume median diameter with 1% mass <10 microm. The localization of the spray was studied in hollow cast models of human airways. 99mTc-sulfur colloid was used as a radiolabeled marker for these studies. Localization of the deposited spray was determined by scintigraphy and by measuring the radioactivity exiting the terminal airways. In the lung casts the spray was localized to one or two generations over an approximately 2-cm2 area. We conclude that delivery of large droplet sprays limits exposure to a few generations and may be useful in topical gene delivery clinical trials." @default.
• W2088895515 created "2016-06-24" @default.
• W2088895515 creator A5001582587 @default.
• W2088895515 creator A5035522216 @default.
• W2088895515 creator A5045929439 @default.
• W2088895515 creator A5048859997 @default.
• W2088895515 creator A5056500136 @default.
• W2088895515 creator A5090727487 @default.
• W2088895515 date "2000-01-20" @default.
• W2088895515 modified "2023-10-16" @default.
• W2088895515 title "Coarse Spray Delivery to a Localized Region of the Pulmonary Airways for Gene Therapy" @default.
• W2088895515 cites W1527590544 @default.
• W2088895515 cites W1781645578 @default.
• W2088895515 cites W1952565680 @default.
• W2088895515 cites W1969761877 @default.
• W2088895515 cites W1975270131 @default.
• W2088895515 cites W1981601650 @default.
• W2088895515 cites W1996234604 @default.
• W2088895515 cites W2001757989 @default.
• W2088895515 cites W2015617337 @default.
• W2088895515 cites W2016120058 @default.
• W2088895515 cites W2016306950 @default.
• W2088895515 cites W2042761699 @default.
• W2088895515 cites W2044296969 @default.
• W2088895515 cites W2054825059 @default.
• W2088895515 cites W2076693792 @default.
• W2088895515 cites W2096576290 @default.
• W2088895515 cites W2139123153 @default.
• W2088895515 cites W2148793772 @default.
• W2088895515 cites W2257685225 @default.
• W2088895515 cites W2341939190 @default.
• W2088895515 cites W4301259126 @default.
• W2088895515 doi "https://doi.org/10.1089/10430340050016085" @default.
• W2088895515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10680848" @default.
• W2088895515 hasPublicationYear "2000" @default.
• W2088895515 type Work @default.
• W2088895515 sameAs 2088895515 @default.
• W2088895515 citedByCount "21" @default.
• W2088895515 countsByYear W20888955152012 @default.
• W2088895515 countsByYear W20888955152013 @default.
• W2088895515 countsByYear W20888955152014 @default.
• W2088895515 countsByYear W20888955152022 @default.
• W2088895515 crossrefType "journal-article" @default.
• W2088895515 hasAuthorship W2088895515A5001582587 @default.
• W2088895515 hasAuthorship W2088895515A5035522216 @default.
• W2088895515 hasAuthorship W2088895515A5045929439 @default.
• W2088895515 hasAuthorship W2088895515A5048859997 @default.
• W2088895515 hasAuthorship W2088895515A5056500136 @default.
• W2088895515 hasAuthorship W2088895515A5090727487 @default.
• W2088895515 hasConcept C104317684 @default.
• W2088895515 hasConcept C105702510 @default.
• W2088895515 hasConcept C111599444 @default.
• W2088895515 hasConcept C121332964 @default.
• W2088895515 hasConcept C126322002 @default.
• W2088895515 hasConcept C135983454 @default.
• W2088895515 hasConcept C136229726 @default.
• W2088895515 hasConcept C142724271 @default.
• W2088895515 hasConcept C185592680 @default.
• W2088895515 hasConcept C192562407 @default.
• W2088895515 hasConcept C2776938444 @default.
• W2088895515 hasConcept C2776954882 @default.
• W2088895515 hasConcept C2777714996 @default.
• W2088895515 hasConcept C2780051367 @default.
• W2088895515 hasConcept C2989005 @default.
• W2088895515 hasConcept C32470452 @default.
• W2088895515 hasConcept C40767141 @default.
• W2088895515 hasConcept C55493867 @default.
• W2088895515 hasConcept C56200935 @default.
• W2088895515 hasConcept C71924100 @default.
• W2088895515 hasConcept C92087593 @default.
• W2088895515 hasConcept C97355855 @default.
• W2088895515 hasConceptScore W2088895515C104317684 @default.
• W2088895515 hasConceptScore W2088895515C105702510 @default.
• W2088895515 hasConceptScore W2088895515C111599444 @default.
• W2088895515 hasConceptScore W2088895515C121332964 @default.
• W2088895515 hasConceptScore W2088895515C126322002 @default.
• W2088895515 hasConceptScore W2088895515C135983454 @default.
• W2088895515 hasConceptScore W2088895515C136229726 @default.
• W2088895515 hasConceptScore W2088895515C142724271 @default.
• W2088895515 hasConceptScore W2088895515C185592680 @default.
• W2088895515 hasConceptScore W2088895515C192562407 @default.
• W2088895515 hasConceptScore W2088895515C2776938444 @default.
• W2088895515 hasConceptScore W2088895515C2776954882 @default.
• W2088895515 hasConceptScore W2088895515C2777714996 @default.
• W2088895515 hasConceptScore W2088895515C2780051367 @default.
• W2088895515 hasConceptScore W2088895515C2989005 @default.
• W2088895515 hasConceptScore W2088895515C32470452 @default.
• W2088895515 hasConceptScore W2088895515C40767141 @default.
• W2088895515 hasConceptScore W2088895515C55493867 @default.
• W2088895515 hasConceptScore W2088895515C56200935 @default.
• W2088895515 hasConceptScore W2088895515C71924100 @default.
• W2088895515 hasConceptScore W2088895515C92087593 @default.
• W2088895515 hasConceptScore W2088895515C97355855 @default.
• W2088895515 hasIssue "2" @default.
• W2088895515 hasLocation W20888955151 @default.
• W2088895515 hasLocation W20888955152 @default.
• W2088895515 hasOpenAccess W2088895515 @default.
• W2088895515 hasPrimaryLocation W20888955151 @default.

• next