Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088895867> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2088895867 endingPage "260" @default.
- W2088895867 startingPage "260" @default.
- W2088895867 abstract "Underphosphorylated retinoblastoma (Rb) protein inhibits progression around the cell cycle by binding to transcription factors like E2F; subsequent hyperphosphorylation of Rb protein releases E2F from the complex so that it can then drive the cell into S phase. We immunolocalized Rb protein in human cells during the cell cycle. Rb protein translocated into nucleoli after DNA replication completed, and the nucleolar Rb was shown to be in the hyperphosphorylated form by immunoblotting. This form, but not its underphosphorylated counterpart, interacted with the nucleolar protein nucleophosmin/B23. The two formed a salt-resistant complex in vitro, and the two could be immunoprecipitated together from nucleolar extracts. These results suggest that hyperphosphorylated Rb protein is imported into nucleoli late in S or G2 phase with nucleophosmin/B23. Analysis of the nucleolar location of Rb protein using various deletion mutants tagged with the green fluorescent protein implicated pocket A of Rb protein as the region responsible for nucleolar targeting; this region also interacted with nucleophosmin/B23. Nucleolar translocation of Rb mutant was inhibited by introducing nucleophosmin/B23 antisense oligomer. These results suggest that nucleolar translocation of Rb protein is promoted by the binding with nucleophosmin/B23 via the pocket A region." @default.
- W2088895867 created "2016-06-24" @default.
- W2088895867 creator A5014838335 @default.
- W2088895867 creator A5026226715 @default.
- W2088895867 creator A5040891315 @default.
- W2088895867 creator A5044243669 @default.
- W2088895867 creator A5075183737 @default.
- W2088895867 date "1992-01-01" @default.
- W2088895867 modified "2023-09-24" @default.
- W2088895867 title "46. Therapeutic utility of antisense (AS) oligodeoxynucleotides in vitro and in vivo" @default.
- W2088895867 doi "https://doi.org/10.1016/0753-3322(92)90131-p" @default.
- W2088895867 hasPublicationYear "1992" @default.
- W2088895867 type Work @default.
- W2088895867 sameAs 2088895867 @default.
- W2088895867 citedByCount "0" @default.
- W2088895867 crossrefType "journal-article" @default.
- W2088895867 hasAuthorship W2088895867A5014838335 @default.
- W2088895867 hasAuthorship W2088895867A5026226715 @default.
- W2088895867 hasAuthorship W2088895867A5040891315 @default.
- W2088895867 hasAuthorship W2088895867A5044243669 @default.
- W2088895867 hasAuthorship W2088895867A5075183737 @default.
- W2088895867 hasConcept C104317684 @default.
- W2088895867 hasConcept C1491633281 @default.
- W2088895867 hasConcept C153911025 @default.
- W2088895867 hasConcept C183873130 @default.
- W2088895867 hasConcept C184235292 @default.
- W2088895867 hasConcept C185592680 @default.
- W2088895867 hasConcept C190062978 @default.
- W2088895867 hasConcept C2776062698 @default.
- W2088895867 hasConcept C2776525860 @default.
- W2088895867 hasConcept C2778198054 @default.
- W2088895867 hasConcept C2908722627 @default.
- W2088895867 hasConcept C29512474 @default.
- W2088895867 hasConcept C29537977 @default.
- W2088895867 hasConcept C54355233 @default.
- W2088895867 hasConcept C55493867 @default.
- W2088895867 hasConcept C71829478 @default.
- W2088895867 hasConcept C81885089 @default.
- W2088895867 hasConcept C83258922 @default.
- W2088895867 hasConcept C86339819 @default.
- W2088895867 hasConcept C86803240 @default.
- W2088895867 hasConcept C95444343 @default.
- W2088895867 hasConceptScore W2088895867C104317684 @default.
- W2088895867 hasConceptScore W2088895867C1491633281 @default.
- W2088895867 hasConceptScore W2088895867C153911025 @default.
- W2088895867 hasConceptScore W2088895867C183873130 @default.
- W2088895867 hasConceptScore W2088895867C184235292 @default.
- W2088895867 hasConceptScore W2088895867C185592680 @default.
- W2088895867 hasConceptScore W2088895867C190062978 @default.
- W2088895867 hasConceptScore W2088895867C2776062698 @default.
- W2088895867 hasConceptScore W2088895867C2776525860 @default.
- W2088895867 hasConceptScore W2088895867C2778198054 @default.
- W2088895867 hasConceptScore W2088895867C2908722627 @default.
- W2088895867 hasConceptScore W2088895867C29512474 @default.
- W2088895867 hasConceptScore W2088895867C29537977 @default.
- W2088895867 hasConceptScore W2088895867C54355233 @default.
- W2088895867 hasConceptScore W2088895867C55493867 @default.
- W2088895867 hasConceptScore W2088895867C71829478 @default.
- W2088895867 hasConceptScore W2088895867C81885089 @default.
- W2088895867 hasConceptScore W2088895867C83258922 @default.
- W2088895867 hasConceptScore W2088895867C86339819 @default.
- W2088895867 hasConceptScore W2088895867C86803240 @default.
- W2088895867 hasConceptScore W2088895867C95444343 @default.
- W2088895867 hasIssue "5-7" @default.
- W2088895867 hasLocation W20888958671 @default.
- W2088895867 hasOpenAccess W2088895867 @default.
- W2088895867 hasPrimaryLocation W20888958671 @default.
- W2088895867 hasRelatedWork W1481014355 @default.
- W2088895867 hasRelatedWork W1901561690 @default.
- W2088895867 hasRelatedWork W1969447384 @default.
- W2088895867 hasRelatedWork W2021956465 @default.
- W2088895867 hasRelatedWork W2029929063 @default.
- W2088895867 hasRelatedWork W2080697050 @default.
- W2088895867 hasRelatedWork W2106988081 @default.
- W2088895867 hasRelatedWork W2130070305 @default.
- W2088895867 hasRelatedWork W2153285444 @default.
- W2088895867 hasRelatedWork W2409059575 @default.
- W2088895867 hasVolume "46" @default.
- W2088895867 isParatext "false" @default.
- W2088895867 isRetracted "false" @default.
- W2088895867 magId "2088895867" @default.
- W2088895867 workType "article" @default.