FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088895925> ?p ?o ?g. }

• W2088895925 endingPage "64" @default.
• W2088895925 startingPage "59" @default.
• W2088895925 abstract "SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correlating the response to nab-paclitaxel and SPARC tumor expression in a retrospective analysis of a 60-patient clinical study of nab-paclitaxel as monotherapy against head and neck cancer. Sixteen tumor specimens were available for analysis. There were 11 responders (CR/PR) and 5 nonresponders (SD/PD) among the 16 nab-paclitaxel-treated patients (12/16 SPARC-positive, 75%). Response to nab-paclitaxel was higher for SPARC-positive patients (10/12, 83%) than SPARC-negative patients (1/4, 25%). The SPARC-negative patients exhibited significantly lower response than the overall response rate among all 60 patients (1/4, 25% vs 45/60, 75%). Although preliminary, data are supportive of the hypothesis that SPARC overexpression may correlate with response to nab-paclitaxel. If confirmed in larger studies, treatment with nab-paclitaxel may convert a poor prognosis SPARC-positive patient population into a group with better clinical outcomes." @default.
• W2088895925 created "2016-06-24" @default.
• W2088895925 creator A5020589513 @default.
• W2088895925 creator A5040852712 @default.
• W2088895925 creator A5059615305 @default.
• W2088895925 creator A5087962211 @default.
• W2088895925 date "2009-06-01" @default.
• W2088895925 modified "2023-10-12" @default.
• W2088895925 title "SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients" @default.
• W2088895925 cites W1605327673 @default.
• W2088895925 cites W1647414470 @default.
• W2088895925 cites W1982066003 @default.
• W2088895925 cites W1991525295 @default.
• W2088895925 cites W2032488683 @default.
• W2088895925 cites W2043103956 @default.
• W2088895925 cites W2046516625 @default.
• W2088895925 cites W2047737749 @default.
• W2088895925 cites W2066742760 @default.
• W2088895925 cites W2066908770 @default.
• W2088895925 cites W2090280374 @default.
• W2088895925 cites W2128939579 @default.
• W2088895925 cites W2144536924 @default.
• W2088895925 cites W2144699072 @default.
• W2088895925 cites W2153017356 @default.
• W2088895925 cites W4248057807 @default.
• W2088895925 doi "https://doi.org/10.1593/tlo.09109" @default.
• W2088895925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670572" @default.
• W2088895925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19412420" @default.
• W2088895925 hasPublicationYear "2009" @default.
• W2088895925 type Work @default.
• W2088895925 sameAs 2088895925 @default.
• W2088895925 citedByCount "328" @default.
• W2088895925 countsByYear W20888959252012 @default.
• W2088895925 countsByYear W20888959252013 @default.
• W2088895925 countsByYear W20888959252014 @default.
• W2088895925 countsByYear W20888959252015 @default.
• W2088895925 countsByYear W20888959252016 @default.
• W2088895925 countsByYear W20888959252017 @default.
• W2088895925 countsByYear W20888959252018 @default.
• W2088895925 countsByYear W20888959252019 @default.
• W2088895925 countsByYear W20888959252020 @default.
• W2088895925 countsByYear W20888959252021 @default.
• W2088895925 countsByYear W20888959252022 @default.
• W2088895925 countsByYear W20888959252023 @default.
• W2088895925 crossrefType "journal-article" @default.
• W2088895925 hasAuthorship W2088895925A5020589513 @default.
• W2088895925 hasAuthorship W2088895925A5040852712 @default.
• W2088895925 hasAuthorship W2088895925A5059615305 @default.
• W2088895925 hasAuthorship W2088895925A5087962211 @default.
• W2088895925 hasBestOaLocation W20888959251 @default.
• W2088895925 hasConcept C121608353 @default.
• W2088895925 hasConcept C126322002 @default.
• W2088895925 hasConcept C141071460 @default.
• W2088895925 hasConcept C143998085 @default.
• W2088895925 hasConcept C2776125364 @default.
• W2088895925 hasConcept C2776530083 @default.
• W2088895925 hasConcept C2776694085 @default.
• W2088895925 hasConcept C2777292972 @default.
• W2088895925 hasConcept C2908647359 @default.
• W2088895925 hasConcept C2910430875 @default.
• W2088895925 hasConcept C3018411727 @default.
• W2088895925 hasConcept C3019894029 @default.
• W2088895925 hasConcept C71924100 @default.
• W2088895925 hasConcept C99454951 @default.
• W2088895925 hasConceptScore W2088895925C121608353 @default.
• W2088895925 hasConceptScore W2088895925C126322002 @default.
• W2088895925 hasConceptScore W2088895925C141071460 @default.
• W2088895925 hasConceptScore W2088895925C143998085 @default.
• W2088895925 hasConceptScore W2088895925C2776125364 @default.
• W2088895925 hasConceptScore W2088895925C2776530083 @default.
• W2088895925 hasConceptScore W2088895925C2776694085 @default.
• W2088895925 hasConceptScore W2088895925C2777292972 @default.
• W2088895925 hasConceptScore W2088895925C2908647359 @default.
• W2088895925 hasConceptScore W2088895925C2910430875 @default.
• W2088895925 hasConceptScore W2088895925C3018411727 @default.
• W2088895925 hasConceptScore W2088895925C3019894029 @default.
• W2088895925 hasConceptScore W2088895925C71924100 @default.
• W2088895925 hasConceptScore W2088895925C99454951 @default.
• W2088895925 hasIssue "2" @default.
• W2088895925 hasLocation W20888959251 @default.
• W2088895925 hasLocation W20888959252 @default.
• W2088895925 hasLocation W20888959253 @default.
• W2088895925 hasLocation W20888959254 @default.
• W2088895925 hasOpenAccess W2088895925 @default.
• W2088895925 hasPrimaryLocation W20888959251 @default.
• W2088895925 hasRelatedWork W1979477723 @default.
• W2088895925 hasRelatedWork W2001929839 @default.
• W2088895925 hasRelatedWork W2088895925 @default.
• W2088895925 hasRelatedWork W2135229655 @default.
• W2088895925 hasRelatedWork W2315201629 @default.
• W2088895925 hasRelatedWork W2529376761 @default.
• W2088895925 hasRelatedWork W2890221863 @default.
• W2088895925 hasRelatedWork W3045606121 @default.
• W2088895925 hasRelatedWork W3093839760 @default.
• W2088895925 hasRelatedWork W4288740378 @default.
• W2088895925 hasVolume "2" @default.
• W2088895925 isParatext "false" @default.
• W2088895925 isRetracted "false" @default.

• next