Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088896460> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2088896460 endingPage "28" @default.
- W2088896460 startingPage "15" @default.
- W2088896460 abstract "In this study we investigated the function of p53 as a regulator of cell cycle progression in cycling and senescent cells. Using the conditional temperature-sensitive (ts) mutant we could prevent the detrimental effect of constitutive expression of high levels of wt p53 protein. High levels of wt p53 inhibited cell proliferation by blocking the cells to progress from G1 to S phase of the cell cycle. Flow cytometric analysis revelaed a maintenance of G1 cell population for a longer time depending on the prolonged expression of wt p53 protein. The p53 mediated inhibition of cell proliferation and of the cycle was reversible. However, a spontaneous increase of wt p53 occurring in ageing normal human MRC-5 fibroblasts was associated with irreversible reduction of proliferative potential. The accumulation of G1 cells was detected by flow cytometry. By the measurement of DNA content it is not possible to discriminate between cells arrested in G1 and G0 phase, therefore, the expression of G1 markers was determined. Analysis of the expression of distinct cell cycle regulators revealed that quiescent MRC-5 cells were in G0 phase. Our results indicate that cell cycle arrest occurring in senescent cells is associated with the G0 transition." @default.
- W2088896460 created "2016-06-24" @default.
- W2088896460 creator A5008317857 @default.
- W2088896460 creator A5023312986 @default.
- W2088896460 creator A5049681995 @default.
- W2088896460 creator A5087527842 @default.
- W2088896460 date "2005-03-01" @default.
- W2088896460 modified "2023-09-23" @default.
- W2088896460 title "Role of p53 tumor suppressor in ageing: regulation of transient cell cycle arrest and terminal senescence." @default.
- W2088896460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15795472" @default.
- W2088896460 hasPublicationYear "2005" @default.
- W2088896460 type Work @default.
- W2088896460 sameAs 2088896460 @default.
- W2088896460 citedByCount "7" @default.
- W2088896460 countsByYear W20888964602012 @default.
- W2088896460 countsByYear W20888964602013 @default.
- W2088896460 countsByYear W20888964602015 @default.
- W2088896460 countsByYear W20888964602017 @default.
- W2088896460 crossrefType "journal-article" @default.
- W2088896460 hasAuthorship W2088896460A5008317857 @default.
- W2088896460 hasAuthorship W2088896460A5023312986 @default.
- W2088896460 hasAuthorship W2088896460A5049681995 @default.
- W2088896460 hasAuthorship W2088896460A5087527842 @default.
- W2088896460 hasConcept C105696609 @default.
- W2088896460 hasConcept C143425029 @default.
- W2088896460 hasConcept C144024400 @default.
- W2088896460 hasConcept C1491633281 @default.
- W2088896460 hasConcept C149923435 @default.
- W2088896460 hasConcept C153911025 @default.
- W2088896460 hasConcept C185592680 @default.
- W2088896460 hasConcept C25311885 @default.
- W2088896460 hasConcept C2908647359 @default.
- W2088896460 hasConcept C29537977 @default.
- W2088896460 hasConcept C522857546 @default.
- W2088896460 hasConcept C552990157 @default.
- W2088896460 hasConcept C553184892 @default.
- W2088896460 hasConcept C55493867 @default.
- W2088896460 hasConcept C62112901 @default.
- W2088896460 hasConcept C86803240 @default.
- W2088896460 hasConcept C95444343 @default.
- W2088896460 hasConceptScore W2088896460C105696609 @default.
- W2088896460 hasConceptScore W2088896460C143425029 @default.
- W2088896460 hasConceptScore W2088896460C144024400 @default.
- W2088896460 hasConceptScore W2088896460C1491633281 @default.
- W2088896460 hasConceptScore W2088896460C149923435 @default.
- W2088896460 hasConceptScore W2088896460C153911025 @default.
- W2088896460 hasConceptScore W2088896460C185592680 @default.
- W2088896460 hasConceptScore W2088896460C25311885 @default.
- W2088896460 hasConceptScore W2088896460C2908647359 @default.
- W2088896460 hasConceptScore W2088896460C29537977 @default.
- W2088896460 hasConceptScore W2088896460C522857546 @default.
- W2088896460 hasConceptScore W2088896460C552990157 @default.
- W2088896460 hasConceptScore W2088896460C553184892 @default.
- W2088896460 hasConceptScore W2088896460C55493867 @default.
- W2088896460 hasConceptScore W2088896460C62112901 @default.
- W2088896460 hasConceptScore W2088896460C86803240 @default.
- W2088896460 hasConceptScore W2088896460C95444343 @default.
- W2088896460 hasIssue "1" @default.
- W2088896460 hasLocation W20888964601 @default.
- W2088896460 hasOpenAccess W2088896460 @default.
- W2088896460 hasPrimaryLocation W20888964601 @default.
- W2088896460 hasRelatedWork W1970867969 @default.
- W2088896460 hasRelatedWork W1983052307 @default.
- W2088896460 hasRelatedWork W1983215963 @default.
- W2088896460 hasRelatedWork W1989875808 @default.
- W2088896460 hasRelatedWork W1992473001 @default.
- W2088896460 hasRelatedWork W1996966832 @default.
- W2088896460 hasRelatedWork W2015519364 @default.
- W2088896460 hasRelatedWork W2023467288 @default.
- W2088896460 hasRelatedWork W2028361915 @default.
- W2088896460 hasRelatedWork W2031642772 @default.
- W2088896460 hasRelatedWork W2031881900 @default.
- W2088896460 hasRelatedWork W2035974767 @default.
- W2088896460 hasRelatedWork W2058833081 @default.
- W2088896460 hasRelatedWork W2068482381 @default.
- W2088896460 hasRelatedWork W2070655871 @default.
- W2088896460 hasRelatedWork W2109118524 @default.
- W2088896460 hasRelatedWork W2119075351 @default.
- W2088896460 hasRelatedWork W2150043577 @default.
- W2088896460 hasRelatedWork W2388594455 @default.
- W2088896460 hasRelatedWork W2884252608 @default.
- W2088896460 hasVolume "56" @default.
- W2088896460 isParatext "false" @default.
- W2088896460 isRetracted "false" @default.
- W2088896460 magId "2088896460" @default.
- W2088896460 workType "article" @default.