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- W2088897022 abstract "Abstract Possible cellular sites to form superoxide (O2−) and H2O2 were studied in polymorphonuclear leukocytes stimulated with either cytochalasin D (CD) or bacteria. When the cells were stimulated with cytochalasin, the ratio of O2− to H2O2 appearing in the medium was about 2 (determined separately) and the appearance of H2O2 in the medium was inhibited by the addition of cytochrome c, a scavenger of O2−. The inhibition was reversed by the addition of superoxide dismutase. The cells phagocytosing bacteria released O2− at the beginning but the release subsided corresponding to the increase in the direct release of H2O2. p-Chloromercuribenzenesulfonate, a non-permeant reagent, inhibited the H2O2 formation by the cells stimulated with CD, whereas it did not inhibit the formation by the phagocytosing cells. These observations supported a hypothesis that the cells stimulated with the cytochalasin release O2− from the cell surface, whereas the phagocytosing cells release H2O2 from an intracellular site, probably the phagosomes formed by the invagination of the plasma membrane. An electron microscopic finding that the vacuole-like structures found in the cytochalasin-treated cells have openings to outside, also supported the hypothesis. The particle-bound NADPH-oxidase activity of the cytochalasin-treated cells was several times higher than that of the resting cells and the activation was apparently parallel with the O2−-releasing activity of the cells. No activation of the NADH-oxidase was observed." @default.
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- W2088897022 date "1979-12-01" @default.
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- W2088897022 title "Hydrogen peroxide formation of polymorphonuclear leukocytes stimulated with cytochalasin D" @default.
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- W2088897022 doi "https://doi.org/10.1016/0014-4827(79)90205-2" @default.
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