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- W2088897990 abstract "Obstructive sleep apnea syndrome (OSAS) is an important comorbidity in patients with acromegaly. Polysomnography (PSG) is considered the gold standard in the diagnosis of sleep apnea syndrome (SAS). However, in clinical practice because of costs and labor-intensity it is not performed routinely. ApneaLink, a newly developed screening device is based on respiratory pressure measurements via nasal canula as an alternative sensitive method for SAS detection in combination with measurement of oxygen desaturation. This method allows analysis of apnoeas, hypopnoeas, snoring and oxygen desaturation. Aim of this study was to evaluate the reliability of ApneaLink in diagnosing OSAS in patients with acromegaly, simultaneously studied by PSG in a sleep laboratory and by the ApneaLink method. In 11 patients with confirmed acromegaly suspected of having OSAS (5 men, mean age 42 [28–57], mean IGF-I SDS 1.54 [1.06–3.97]), we compared ApneaLink-generated analysis with results of simultaneously collected PSG. All patients were treated for acromegaly and on stable doses of sandostatin (n=6), pegvisomant (n=3) or cabergoline+sandostatin (n=2). 3/10 patients had active acromegaly with elevated IGF-I SDS. Apnea hypopnea index (AHI) was defined as number of apneas and hypopneas/h of sleep. The polysomnographic criterion for OSAS was a more than 10 apnea-hypopnea episodes plus micro-awakenings related to respiratory efforts/h of sleep. ApneaLink- and PSG-generated numbers of apnoeas (r=0.91) and hypopnoeas (r=0.81) as well as AHI (r=0.92) correlated highly, displaying mean difference in AHI of 3.5/h Sensitivity and specificity for SAS was 100% and 86.8%, at SAS-defining AHI of 10. Mean (94%, r=0.90) and minimal (86%, r=0.90) oxygen concentration correlated highly. There is high concordance of AHI and ODI between the two methods. ApneaLink-generated AHIs are highly sensitive in detecting SAS in patients with acromegaly. ApneaLink, therefore, is a simple screening device for SAS in patients with acromegaly." @default.
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- W2088897990 date "2007-09-10" @default.
- W2088897990 modified "2023-09-26" @default.
- W2088897990 title "Evaluation of ApneaLink as a screening device for sleep apnea syndrome in patients with acromegaly" @default.
- W2088897990 doi "https://doi.org/10.1055/s-2007-990428" @default.
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