FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088900329> ?p ?o ?g. }

• W2088900329 endingPage "704" @default.
• W2088900329 startingPage "695" @default.
• W2088900329 abstract "Recent work with approaches like recombinant mutants and X-ray crystallography has given much new information about the ligand-binding properties of human serum albumin (HSA). The information increases the understanding of this unique transport and depot protein and could give a structural basis for the possible construction of therapeutic agents with altered HSA-binding properties. A tabulation of high-affinity binding sites for both endogenous and exogenous compounds has been made; it could be useful for the above-mentioned purpose, but it could also be of value when trying to predict potential drug interactions at the protein-binding level. Drug displacement is not always a complication to therapy; it can be used to increase the biological effect of a drug. However, due to rebinding at other sites, the increase in the free concentration of a displaced ligand can be less than expected. Drugs and drug metabolites can also interact covalently with HSA; thiol-containing drugs often bind to the single free cysteine residue of HSA, and glucuronidated drugs react irreversibly with other residues of the protein. Reversible binding of ligands is often stereospecific, and therefore immobilized HSA can be used to separate drug isomers. Albumin-containing dialysates are useful for extracorporeal removal of endogenous toxins and in the treatment of drug overdoses. HSA has different types of hydrolytic activities, which also can be stereospecific. The esterase-like property seems especially useful in converting prodrugs to active drugs in plasma." @default.
• W2088900329 created "2016-06-24" @default.
• W2088900329 creator A5026222199 @default.
• W2088900329 creator A5042439651 @default.
• W2088900329 creator A5080042545 @default.
• W2088900329 date "2002-01-01" @default.
• W2088900329 modified "2023-10-14" @default.
• W2088900329 title "Practical Aspects of the Ligand-Binding and Enzymatic Properties of Human Serum Albumin." @default.
• W2088900329 cites W130364474 @default.
• W2088900329 cites W14213215 @default.
• W2088900329 cites W146927540 @default.
• W2088900329 cites W1504651650 @default.
• W2088900329 cites W1504792186 @default.
• W2088900329 cites W1518280140 @default.
• W2088900329 cites W1520399629 @default.
• W2088900329 cites W1559093789 @default.
• W2088900329 cites W1581280867 @default.
• W2088900329 cites W1596693579 @default.
• W2088900329 cites W163339364 @default.
• W2088900329 cites W1795535587 @default.
• W2088900329 cites W1845962002 @default.
• W2088900329 cites W1851660174 @default.
• W2088900329 cites W1940950303 @default.
• W2088900329 cites W1954882272 @default.
• W2088900329 cites W1964900539 @default.
• W2088900329 cites W1966117276 @default.
• W2088900329 cites W1967960010 @default.
• W2088900329 cites W1968418371 @default.
• W2088900329 cites W1969179965 @default.
• W2088900329 cites W1971465833 @default.
• W2088900329 cites W1971642149 @default.
• W2088900329 cites W1973238993 @default.
• W2088900329 cites W1973950263 @default.
• W2088900329 cites W1977211541 @default.
• W2088900329 cites W1978649563 @default.
• W2088900329 cites W1980078657 @default.
• W2088900329 cites W1980599353 @default.
• W2088900329 cites W1982738247 @default.
• W2088900329 cites W1984747998 @default.
• W2088900329 cites W1985241395 @default.
• W2088900329 cites W1985472375 @default.
• W2088900329 cites W1985768295 @default.
• W2088900329 cites W1986313590 @default.
• W2088900329 cites W1986966205 @default.
• W2088900329 cites W1987939033 @default.
• W2088900329 cites W1988240997 @default.
• W2088900329 cites W1990931737 @default.
• W2088900329 cites W1997295916 @default.
• W2088900329 cites W2000236508 @default.
• W2088900329 cites W2000453566 @default.
• W2088900329 cites W2000704789 @default.
• W2088900329 cites W2004716753 @default.
• W2088900329 cites W2006436157 @default.
• W2088900329 cites W2008813047 @default.
• W2088900329 cites W2008998736 @default.
• W2088900329 cites W2014477053 @default.
• W2088900329 cites W2015022195 @default.
• W2088900329 cites W2015489056 @default.
• W2088900329 cites W2019090956 @default.
• W2088900329 cites W2022901560 @default.
• W2088900329 cites W2025679243 @default.
• W2088900329 cites W2026266399 @default.
• W2088900329 cites W2030552610 @default.
• W2088900329 cites W2031211170 @default.
• W2088900329 cites W2032646630 @default.
• W2088900329 cites W2032770289 @default.
• W2088900329 cites W2033634414 @default.
• W2088900329 cites W2040245022 @default.
• W2088900329 cites W2040898474 @default.
• W2088900329 cites W2041780922 @default.
• W2088900329 cites W2047382520 @default.
• W2088900329 cites W2048790659 @default.
• W2088900329 cites W2053128592 @default.
• W2088900329 cites W2055032002 @default.
• W2088900329 cites W2056795514 @default.
• W2088900329 cites W2059664574 @default.
• W2088900329 cites W2059865772 @default.
• W2088900329 cites W2062540963 @default.
• W2088900329 cites W2067309219 @default.
• W2088900329 cites W2068976071 @default.
• W2088900329 cites W2069282768 @default.
• W2088900329 cites W2070440601 @default.
• W2088900329 cites W2075631560 @default.
• W2088900329 cites W2080069408 @default.
• W2088900329 cites W2081892234 @default.
• W2088900329 cites W2082247577 @default.
• W2088900329 cites W2085543851 @default.
• W2088900329 cites W2085780483 @default.
• W2088900329 cites W2086064443 @default.
• W2088900329 cites W2086100857 @default.
• W2088900329 cites W2086642358 @default.
• W2088900329 cites W2086755542 @default.
• W2088900329 cites W2090289796 @default.
• W2088900329 cites W2105557491 @default.
• W2088900329 cites W2112656196 @default.
• W2088900329 cites W2118959766 @default.
• W2088900329 cites W2120074234 @default.
• W2088900329 cites W2123474929 @default.

• next