FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088906211> ?p ?o ?g. }

• W2088906211 abstract "The molecular biological approach has provided important information for understanding the F0F1 H(+)-ATPase. This article focuses on our recent results on the catalytic site in the beta subunit, and the roles of alpha/beta subunit interaction and amino/carboxyl terminal interaction of the gamma subunit in energy coupling. Extensive mutagenesis of the beta subunit revealed that beta Lys-155, beta Thr-156, beta Glu-181 and beta Arg-182 are essential catalytic residues. beta Glu-185 is not absolutely essential, but a carboxyl residue may be necessary at this position. A pseudo-revertant analysis positioned beta Gly-172, beta Ser-174, beta Glu-192 and beta Val-198 in the proximity of beta Gly-149. The finding of the roles of beta Gly-149, beta Lys-155, and beta Thr-156 emphasized the importance of the glycine-rich sequence (Gly-X-X-X-X-Gly-Lys-Thr/Ser, E. coli beta residues between beta Gly-149 and beta Thr-156) conserved in many nucleotide binding proteins. The A subunits of vacuolar type ATPases may have a similar catalytic mechanism because they have conserved glycine-rich and Gly-Glu-Arg (corresponding to beta Gly-180-beta Arg-182) sequences. The results of these mutational studies are consistent with the labeling of beta Lys-155 and beta Lys-201 with AP3-PL, and of beta Glu-192 with DCCD [15]. The DCCD-binding residue of a thermophilic Bacillus corresponds to beta Glu-181, an essential catalytic residue discussed above. The defective coupling of the beta Ser-174-->Phe mutant was suppressed by the second mutation alpha Arg-296-->Cys, indicating the importance of alpha/beta interaction in energy coupling. The gamma subunit, especially its amino/carboxyl interaction, seems to be essential for energy coupling between catalysis and transport judging from studies on gamma Met-23-->Lys or Arg mutation and second-site mutations which suppressed the gamma Lys-23 mutation. Thus the conserved gamma Met-23 is not absolutely essential but is located in the important region for amino/carboxyl interaction for energy coupling." @default.
• W2088906211 created "2016-06-24" @default.
• W2088906211 creator A5004964979 @default.
• W2088906211 creator A5024532915 @default.
• W2088906211 creator A5028042430 @default.
• W2088906211 creator A5046527579 @default.
• W2088906211 creator A5089202528 @default.
• W2088906211 date "1994-08-01" @default.
• W2088906211 modified "2023-09-27" @default.
• W2088906211 title "Catalysis and energy coupling of H+-ATPase (ATP synthase): Molecular biological approaches" @default.
• W2088906211 cites W124504601 @default.
• W2088906211 cites W1502871917 @default.
• W2088906211 cites W1510429270 @default.
• W2088906211 cites W1513838989 @default.
• W2088906211 cites W1536337095 @default.
• W2088906211 cites W1558372296 @default.
• W2088906211 cites W1563275650 @default.
• W2088906211 cites W1572919579 @default.
• W2088906211 cites W1576285340 @default.
• W2088906211 cites W1580223847 @default.
• W2088906211 cites W1586050293 @default.
• W2088906211 cites W1593015025 @default.
• W2088906211 cites W1603676703 @default.
• W2088906211 cites W1604488369 @default.
• W2088906211 cites W1723834035 @default.
• W2088906211 cites W1918788452 @default.
• W2088906211 cites W1928547060 @default.
• W2088906211 cites W1965947845 @default.
• W2088906211 cites W1989266582 @default.
• W2088906211 cites W1990315763 @default.
• W2088906211 cites W2010733175 @default.
• W2088906211 cites W2034133688 @default.
• W2088906211 cites W2041964897 @default.
• W2088906211 cites W2088725926 @default.
• W2088906211 cites W2088906211 @default.
• W2088906211 cites W2091169894 @default.
• W2088906211 cites W2099047634 @default.
• W2088906211 cites W2129683367 @default.
• W2088906211 cites W2140695348 @default.
• W2088906211 cites W2176634422 @default.
• W2088906211 cites W33440140 @default.
• W2088906211 cites W4247602563 @default.
• W2088906211 doi "https://doi.org/10.1016/0005-2728(94)90104-x" @default.
• W2088906211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8075111" @default.
• W2088906211 hasPublicationYear "1994" @default.
• W2088906211 type Work @default.
• W2088906211 sameAs 2088906211 @default.
• W2088906211 citedByCount "12" @default.
• W2088906211 countsByYear W20889062112012 @default.
• W2088906211 crossrefType "journal-article" @default.
• W2088906211 hasAuthorship W2088906211A5004964979 @default.
• W2088906211 hasAuthorship W2088906211A5024532915 @default.
• W2088906211 hasAuthorship W2088906211A5028042430 @default.
• W2088906211 hasAuthorship W2088906211A5046527579 @default.
• W2088906211 hasAuthorship W2088906211A5089202528 @default.
• W2088906211 hasConcept C103408237 @default.
• W2088906211 hasConcept C104292427 @default.
• W2088906211 hasConcept C104317684 @default.
• W2088906211 hasConcept C112243037 @default.
• W2088906211 hasConcept C143065580 @default.
• W2088906211 hasConcept C181199279 @default.
• W2088906211 hasConcept C185592680 @default.
• W2088906211 hasConcept C199360897 @default.
• W2088906211 hasConcept C23265538 @default.
• W2088906211 hasConcept C2776174256 @default.
• W2088906211 hasConcept C41008148 @default.
• W2088906211 hasConcept C55493867 @default.
• W2088906211 hasConcept C71240020 @default.
• W2088906211 hasConceptScore W2088906211C103408237 @default.
• W2088906211 hasConceptScore W2088906211C104292427 @default.
• W2088906211 hasConceptScore W2088906211C104317684 @default.
• W2088906211 hasConceptScore W2088906211C112243037 @default.
• W2088906211 hasConceptScore W2088906211C143065580 @default.
• W2088906211 hasConceptScore W2088906211C181199279 @default.
• W2088906211 hasConceptScore W2088906211C185592680 @default.
• W2088906211 hasConceptScore W2088906211C199360897 @default.
• W2088906211 hasConceptScore W2088906211C23265538 @default.
• W2088906211 hasConceptScore W2088906211C2776174256 @default.
• W2088906211 hasConceptScore W2088906211C41008148 @default.
• W2088906211 hasConceptScore W2088906211C55493867 @default.
• W2088906211 hasConceptScore W2088906211C71240020 @default.
• W2088906211 hasLocation W20889062111 @default.
• W2088906211 hasLocation W20889062112 @default.
• W2088906211 hasOpenAccess W2088906211 @default.
• W2088906211 hasPrimaryLocation W20889062111 @default.
• W2088906211 hasRelatedWork W159004254 @default.
• W2088906211 hasRelatedWork W1881353278 @default.
• W2088906211 hasRelatedWork W1982208178 @default.
• W2088906211 hasRelatedWork W2022242968 @default.
• W2088906211 hasRelatedWork W2045357937 @default.
• W2088906211 hasRelatedWork W2088906211 @default.
• W2088906211 hasRelatedWork W2140673804 @default.
• W2088906211 hasRelatedWork W2187634472 @default.
• W2088906211 hasRelatedWork W2444073884 @default.
• W2088906211 hasRelatedWork W2046865699 @default.
• W2088906211 isParatext "false" @default.
• W2088906211 isRetracted "false" @default.
• W2088906211 magId "2088906211" @default.
• W2088906211 workType "article" @default.