Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088917338> ?p ?o ?g. }
- W2088917338 endingPage "203" @default.
- W2088917338 startingPage "193" @default.
- W2088917338 abstract "Genetic and environmental factors contribute to the onset and progression of lupus. CD4 + T cells from patients with active lupus show a decreased ERK signaling pathway, which causes changes in gene expression. The defect points to its upstream regulator, PKCδ, which exhibits a deficient activity due to oxidative stress. Our aim was to investigate the effect of a defective PKCδ in the development of lupus. We generated a double transgenic C57BL6 × SJL mouse that expresses a doxycycline-induced dominant negative PKCδ (dnPKCδ) in T cells. The transgenic mice displayed decreased T cell ERK signaling, decreased DNMT1 expression and overexpression of methylation sensitive genes involved in the exaggerated immune response in the pathogenesis of lupus. The mice developed anti-dsDNA autoantibodies and glomerulonephritis with IgG deposition. The study indicates common pathogenic mechanisms with human lupus, suggesting that environmentally-mediated T cell PKCδ inactivation plays a causative role in lupus." @default.
- W2088917338 created "2016-06-24" @default.
- W2088917338 creator A5002494862 @default.
- W2088917338 creator A5025715364 @default.
- W2088917338 creator A5030199082 @default.
- W2088917338 creator A5045934111 @default.
- W2088917338 creator A5059600112 @default.
- W2088917338 date "2015-06-01" @default.
- W2088917338 modified "2023-10-17" @default.
- W2088917338 title "T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice" @default.
- W2088917338 cites W1538430276 @default.
- W2088917338 cites W1538433900 @default.
- W2088917338 cites W1576671418 @default.
- W2088917338 cites W1652089898 @default.
- W2088917338 cites W1791411745 @default.
- W2088917338 cites W1806836340 @default.
- W2088917338 cites W1817131636 @default.
- W2088917338 cites W1898378454 @default.
- W2088917338 cites W1963746213 @default.
- W2088917338 cites W1971695868 @default.
- W2088917338 cites W1975165145 @default.
- W2088917338 cites W1986803917 @default.
- W2088917338 cites W1994009027 @default.
- W2088917338 cites W1995665375 @default.
- W2088917338 cites W1998119895 @default.
- W2088917338 cites W2005738993 @default.
- W2088917338 cites W2006981670 @default.
- W2088917338 cites W2011101614 @default.
- W2088917338 cites W2014912378 @default.
- W2088917338 cites W2020699105 @default.
- W2088917338 cites W2022081039 @default.
- W2088917338 cites W2025203589 @default.
- W2088917338 cites W2027259173 @default.
- W2088917338 cites W2034583127 @default.
- W2088917338 cites W2047485710 @default.
- W2088917338 cites W2048132100 @default.
- W2088917338 cites W2049165141 @default.
- W2088917338 cites W20512891 @default.
- W2088917338 cites W2055770867 @default.
- W2088917338 cites W2061521294 @default.
- W2088917338 cites W2063118037 @default.
- W2088917338 cites W2076532551 @default.
- W2088917338 cites W2078472057 @default.
- W2088917338 cites W2079200036 @default.
- W2088917338 cites W2080040722 @default.
- W2088917338 cites W2080145370 @default.
- W2088917338 cites W2080427840 @default.
- W2088917338 cites W2090512296 @default.
- W2088917338 cites W2098976753 @default.
- W2088917338 cites W2106319246 @default.
- W2088917338 cites W2123095447 @default.
- W2088917338 cites W2123669297 @default.
- W2088917338 cites W2126392124 @default.
- W2088917338 cites W2127146201 @default.
- W2088917338 cites W2137154569 @default.
- W2088917338 cites W2138825245 @default.
- W2088917338 cites W2140160913 @default.
- W2088917338 cites W2142930729 @default.
- W2088917338 cites W2146964357 @default.
- W2088917338 cites W2148224923 @default.
- W2088917338 cites W2401901272 @default.
- W2088917338 cites W4211061506 @default.
- W2088917338 cites W4237274532 @default.
- W2088917338 doi "https://doi.org/10.1016/j.clim.2015.03.017" @default.
- W2088917338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4464903" @default.
- W2088917338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25829232" @default.
- W2088917338 hasPublicationYear "2015" @default.
- W2088917338 type Work @default.
- W2088917338 sameAs 2088917338 @default.
- W2088917338 citedByCount "42" @default.
- W2088917338 countsByYear W20889173382015 @default.
- W2088917338 countsByYear W20889173382016 @default.
- W2088917338 countsByYear W20889173382017 @default.
- W2088917338 countsByYear W20889173382018 @default.
- W2088917338 countsByYear W20889173382019 @default.
- W2088917338 countsByYear W20889173382020 @default.
- W2088917338 countsByYear W20889173382021 @default.
- W2088917338 countsByYear W20889173382022 @default.
- W2088917338 countsByYear W20889173382023 @default.
- W2088917338 crossrefType "journal-article" @default.
- W2088917338 hasAuthorship W2088917338A5002494862 @default.
- W2088917338 hasAuthorship W2088917338A5025715364 @default.
- W2088917338 hasAuthorship W2088917338A5030199082 @default.
- W2088917338 hasAuthorship W2088917338A5045934111 @default.
- W2088917338 hasAuthorship W2088917338A5059600112 @default.
- W2088917338 hasBestOaLocation W20889173382 @default.
- W2088917338 hasConcept C126322002 @default.
- W2088917338 hasConcept C153911025 @default.
- W2088917338 hasConcept C195794163 @default.
- W2088917338 hasConcept C203014093 @default.
- W2088917338 hasConcept C2776090121 @default.
- W2088917338 hasConcept C2776912625 @default.
- W2088917338 hasConcept C2779134260 @default.
- W2088917338 hasConcept C2780130043 @default.
- W2088917338 hasConcept C2780942790 @default.
- W2088917338 hasConcept C502942594 @default.
- W2088917338 hasConcept C57074206 @default.
- W2088917338 hasConcept C62478195 @default.