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• W2088925462 startingPage "2843" @default.
• W2088925462 abstract "A 3' poly(A) tail is a common feature of picornavirus RNA genomes and the RNA genomes of many other positive-strand RNA viruses. We examined the manner in which the homopolymeric poly(A) and poly(U) portions of poliovirus (PV) positive- and negative-strand RNAs were used as reciprocal templates during RNA replication. Poly(A) sequences at the 3' end of viral positive-strand RNA were transcribed into VPg-linked poly(U) products at the 5' end of negative-strand RNA during PV RNA replication. Subsequently, VPg-linked poly(U) sequences at the 5' ends of negative-strand RNA templates were transcribed into poly(A) sequences at the 3' ends of positive-strand RNAs. The homopolymeric poly(A) and poly(U) portions of PV RNA products of replication were heterogeneous in length and frequently longer than the corresponding homopolymeric sequences of the respective viral RNA templates. The data support a model of PV RNA replication wherein reiterative transcription of homopolymeric templates ensures the synthesis of long 3' poly(A) tails on progeny RNA genomes." @default.
• W2088925462 created "2016-06-24" @default.
• W2088925462 creator A5052829441 @default.
• W2088925462 creator A5069824126 @default.
• W2088925462 creator A5072765774 @default.
• W2088925462 date "2010-03-15" @default.
• W2088925462 modified "2023-09-25" @default.
• W2088925462 title "Poly(A) at the 3′ End of Positive-Strand RNA and VPg-Linked Poly(U) at the 5′ End of Negative-Strand RNA Are Reciprocal Templates during Replication of Poliovirus RNA" @default.
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• W2088925462 doi "https://doi.org/10.1128/jvi.02620-08" @default.
• W2088925462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2826026" @default.
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• W2088925462 hasPublicationYear "2010" @default.
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