FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088928649> ?p ?o ?g. }

• W2088928649 endingPage "6057" @default.
• W2088928649 startingPage "6048" @default.
• W2088928649 abstract "The neurotransmitter dopamine (DA) modulates brain circuits involved in attention, reward, and motor activity. Synaptic DA homeostasis is primarily controlled via two presynaptic regulatory mechanisms, DA D(2) receptor (D(2)R)-mediated inhibition of DA synthesis and release, and DA transporter (DAT)-mediated DA clearance. D(2)Rs can physically associate with DAT and regulate DAT function, linking DA release and reuptake to a common mechanism. We have established that the attention-deficit hyperactivity disorder-associated human DAT coding variant Ala559Val (hDAT A559V) results in anomalous DA efflux (ADE) similar to that caused by amphetamine-like psychostimulants. Here, we show that tonic activation of D(2)R provides support for hDAT A559V-mediated ADE. We determine in hDAT A559V a pertussis toxin-sensitive, CaMKII-dependent phosphorylation mechanism that supports D(2)R-driven DA efflux. These studies identify a signaling network downstream of D(2)R activation, normally constraining DA action at synapses, that may be altered by DAT mutation to impact risk for DA-related disorders." @default.
• W2088928649 created "2016-06-24" @default.
• W2088928649 creator A5007698609 @default.
• W2088928649 creator A5019043893 @default.
• W2088928649 creator A5022425643 @default.
• W2088928649 creator A5022434803 @default.
• W2088928649 creator A5025327595 @default.
• W2088928649 creator A5040621096 @default.
• W2088928649 creator A5043360534 @default.
• W2088928649 creator A5045487847 @default.
• W2088928649 creator A5051246656 @default.
• W2088928649 creator A5069201685 @default.
• W2088928649 creator A5076865147 @default.
• W2088928649 creator A5087151807 @default.
• W2088928649 date "2010-04-28" @default.
• W2088928649 modified "2023-10-03" @default.
• W2088928649 title "Dysregulation of Dopamine Transporters via Dopamine D₂Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder" @default.
• W2088928649 cites W1519847602 @default.
• W2088928649 cites W1602481380 @default.
• W2088928649 cites W1895466054 @default.
• W2088928649 cites W1925492557 @default.
• W2088928649 cites W1966663884 @default.
• W2088928649 cites W1966667742 @default.
• W2088928649 cites W1967521605 @default.
• W2088928649 cites W1968338376 @default.
• W2088928649 cites W1973422952 @default.
• W2088928649 cites W1976444641 @default.
• W2088928649 cites W1982921266 @default.
• W2088928649 cites W1997829966 @default.
• W2088928649 cites W2004579306 @default.
• W2088928649 cites W2011067932 @default.
• W2088928649 cites W2014793858 @default.
• W2088928649 cites W2028980996 @default.
• W2088928649 cites W2030939829 @default.
• W2088928649 cites W2032957429 @default.
• W2088928649 cites W2036629661 @default.
• W2088928649 cites W2037406484 @default.
• W2088928649 cites W2046518102 @default.
• W2088928649 cites W2048966565 @default.
• W2088928649 cites W2054541146 @default.
• W2088928649 cites W2063987551 @default.
• W2088928649 cites W2074370892 @default.
• W2088928649 cites W2079204641 @default.
• W2088928649 cites W2088027935 @default.
• W2088928649 cites W2090857098 @default.
• W2088928649 cites W2092319509 @default.
• W2088928649 cites W2093713814 @default.
• W2088928649 cites W2097260594 @default.
• W2088928649 cites W2102961821 @default.
• W2088928649 cites W2115518880 @default.
• W2088928649 cites W2117474405 @default.
• W2088928649 cites W2119478024 @default.
• W2088928649 cites W2133046879 @default.
• W2088928649 cites W2133748172 @default.
• W2088928649 cites W2135469628 @default.
• W2088928649 cites W2138538568 @default.
• W2088928649 cites W2143051510 @default.
• W2088928649 cites W2167569489 @default.
• W2088928649 cites W2975983724 @default.
• W2088928649 cites W4238426878 @default.
• W2088928649 cites W4379089834 @default.
• W2088928649 cites W2182295191 @default.
• W2088928649 doi "https://doi.org/10.1523/jneurosci.5094-09.2010" @default.
• W2088928649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881830" @default.
• W2088928649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20427663" @default.
• W2088928649 hasPublicationYear "2010" @default.
• W2088928649 type Work @default.
• W2088928649 sameAs 2088928649 @default.
• W2088928649 citedByCount "109" @default.
• W2088928649 countsByYear W20889286492012 @default.
• W2088928649 countsByYear W20889286492013 @default.
• W2088928649 countsByYear W20889286492014 @default.
• W2088928649 countsByYear W20889286492015 @default.
• W2088928649 countsByYear W20889286492016 @default.
• W2088928649 countsByYear W20889286492017 @default.
• W2088928649 countsByYear W20889286492018 @default.
• W2088928649 countsByYear W20889286492019 @default.
• W2088928649 countsByYear W20889286492020 @default.
• W2088928649 countsByYear W20889286492021 @default.
• W2088928649 countsByYear W20889286492022 @default.
• W2088928649 countsByYear W20889286492023 @default.
• W2088928649 crossrefType "journal-article" @default.
• W2088928649 hasAuthorship W2088928649A5007698609 @default.
• W2088928649 hasAuthorship W2088928649A5019043893 @default.
• W2088928649 hasAuthorship W2088928649A5022425643 @default.
• W2088928649 hasAuthorship W2088928649A5022434803 @default.
• W2088928649 hasAuthorship W2088928649A5025327595 @default.
• W2088928649 hasAuthorship W2088928649A5040621096 @default.
• W2088928649 hasAuthorship W2088928649A5043360534 @default.
• W2088928649 hasAuthorship W2088928649A5045487847 @default.
• W2088928649 hasAuthorship W2088928649A5051246656 @default.
• W2088928649 hasAuthorship W2088928649A5069201685 @default.
• W2088928649 hasAuthorship W2088928649A5076865147 @default.
• W2088928649 hasAuthorship W2088928649A5087151807 @default.
• W2088928649 hasBestOaLocation W20889286491 @default.
• W2088928649 hasConcept C104317684 @default.
• W2088928649 hasConcept C118552586 @default.
• W2088928649 hasConcept C137183658 @default.

• next