FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088929604> ?p ?o ?g. }

• W2088929604 endingPage "205" @default.
• W2088929604 startingPage "195" @default.
• W2088929604 abstract "Botulinum neurotoxins (BoNTs) inhibit cholinergic synaptic transmission by specifically cleaving proteins that are crucial for neurotransmitter exocytosis. Due to the lethality of these toxins, there are elevated concerns regarding their possible use as bioterrorism agents. Moreover, their widespread use for cosmetic purposes, and as medical treatments, has increased the potential risk of accidental overdosing and environmental exposure. Hence, there is an urgent need to develop novel modalities to counter BoNT intoxication. Mammalian motoneurons are the main target of BoNTs; however, due to the difficulty and poor efficiency of the procedures required to isolate the cells, they are not suitable for high-throughput drug screening assays. Here, we explored the suitability of embryonic stem (ES) cell-derived motoneurons as a renewable, reproducible, and physiologically relevant system for BoNT studies. We found that the sensitivity of ES-derived motoneurons to BoNT/A intoxication is comparable to that of primary mouse spinal motoneurons. Additionally, we demonstrated that several BoNT/A inhibitors protected SNAP-25, the BoNT/A substrate, in the ES-derived motoneuron system. Furthermore, this system is compatible with immunofluorescence-based high-throughput studies. These data suggest that ES-derived motoneurons provide a highly sensitive system that is amenable to large-scale screenings to rapidly identify and evaluate the biological efficacies of novel therapeutics." @default.
• W2088929604 created "2016-06-24" @default.
• W2088929604 creator A5000523881 @default.
• W2088929604 creator A5001233790 @default.
• W2088929604 creator A5007492208 @default.
• W2088929604 creator A5017948966 @default.
• W2088929604 creator A5022591131 @default.
• W2088929604 creator A5068707910 @default.
• W2088929604 creator A5081705281 @default.
• W2088929604 creator A5087044972 @default.
• W2088929604 creator A5089081225 @default.
• W2088929604 creator A5089996533 @default.
• W2088929604 date "2011-05-01" @default.
• W2088929604 modified "2023-10-13" @default.
• W2088929604 title "Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery" @default.
• W2088929604 cites W112299954 @default.
• W2088929604 cites W1543585694 @default.
• W2088929604 cites W1596470233 @default.
• W2088929604 cites W1973169354 @default.
• W2088929604 cites W1983878566 @default.
• W2088929604 cites W1988311308 @default.
• W2088929604 cites W1992681202 @default.
• W2088929604 cites W1993581461 @default.
• W2088929604 cites W2002003991 @default.
• W2088929604 cites W2007982098 @default.
• W2088929604 cites W2010233410 @default.
• W2088929604 cites W2011850308 @default.
• W2088929604 cites W2011941918 @default.
• W2088929604 cites W2015925760 @default.
• W2088929604 cites W2039414588 @default.
• W2088929604 cites W2040207971 @default.
• W2088929604 cites W2041691146 @default.
• W2088929604 cites W2045644801 @default.
• W2088929604 cites W2061558355 @default.
• W2088929604 cites W2066248618 @default.
• W2088929604 cites W2071912751 @default.
• W2088929604 cites W2072108954 @default.
• W2088929604 cites W2077168582 @default.
• W2088929604 cites W2078970687 @default.
• W2088929604 cites W2082158539 @default.
• W2088929604 cites W2086580579 @default.
• W2088929604 cites W2088213270 @default.
• W2088929604 cites W2090106870 @default.
• W2088929604 cites W2094100748 @default.
• W2088929604 cites W2095086223 @default.
• W2088929604 cites W2099397608 @default.
• W2088929604 cites W2101339948 @default.
• W2088929604 cites W2111734406 @default.
• W2088929604 cites W2112824422 @default.
• W2088929604 cites W2129075147 @default.
• W2088929604 cites W2129974957 @default.
• W2088929604 cites W2130512418 @default.
• W2088929604 cites W2135107819 @default.
• W2088929604 cites W2135636835 @default.
• W2088929604 cites W2137889830 @default.
• W2088929604 cites W2138497040 @default.
• W2088929604 cites W2139668595 @default.
• W2088929604 cites W2140756516 @default.
• W2088929604 cites W2142787780 @default.
• W2088929604 cites W2148287961 @default.
• W2088929604 cites W2157512308 @default.
• W2088929604 cites W2166825283 @default.
• W2088929604 cites W2170232101 @default.
• W2088929604 cites W2172240851 @default.
• W2088929604 cites W2411247186 @default.
• W2088929604 cites W2418165907 @default.
• W2088929604 cites W69916898 @default.
• W2088929604 doi "https://doi.org/10.1016/j.scr.2011.01.002" @default.
• W2088929604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081902" @default.
• W2088929604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21353660" @default.
• W2088929604 hasPublicationYear "2011" @default.
• W2088929604 type Work @default.
• W2088929604 sameAs 2088929604 @default.
• W2088929604 citedByCount "38" @default.
• W2088929604 countsByYear W20889296042012 @default.
• W2088929604 countsByYear W20889296042013 @default.
• W2088929604 countsByYear W20889296042014 @default.
• W2088929604 countsByYear W20889296042015 @default.
• W2088929604 countsByYear W20889296042016 @default.
• W2088929604 countsByYear W20889296042017 @default.
• W2088929604 countsByYear W20889296042018 @default.
• W2088929604 countsByYear W20889296042019 @default.
• W2088929604 countsByYear W20889296042020 @default.
• W2088929604 countsByYear W20889296042021 @default.
• W2088929604 countsByYear W20889296042022 @default.
• W2088929604 countsByYear W20889296042023 @default.
• W2088929604 crossrefType "journal-article" @default.
• W2088929604 hasAuthorship W2088929604A5000523881 @default.
• W2088929604 hasAuthorship W2088929604A5001233790 @default.
• W2088929604 hasAuthorship W2088929604A5007492208 @default.
• W2088929604 hasAuthorship W2088929604A5017948966 @default.
• W2088929604 hasAuthorship W2088929604A5022591131 @default.
• W2088929604 hasAuthorship W2088929604A5068707910 @default.
• W2088929604 hasAuthorship W2088929604A5081705281 @default.
• W2088929604 hasAuthorship W2088929604A5087044972 @default.
• W2088929604 hasAuthorship W2088929604A5089081225 @default.
• W2088929604 hasAuthorship W2088929604A5089996533 @default.
• W2088929604 hasBestOaLocation W20889296041 @default.

• next