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• W2088948086 abstract "You have accessJournal of UrologyKidney Cancer: Evaluation and Staging II1 Apr 2012699 COMPARISON OF THE 2002 AND 2010 TNM CLASSIFICATION SYSTEM REGARDING THE PREDICTION OF METASTASIS-FREE SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA Georg C. Hutterer, Martin Pichler, Thomas F. Chromecki, Johanna Jesche, Karin Kampel-Kettner, Karl Pummer, and Richard Zigeuner Georg C. HuttererGeorg C. Hutterer Graz, Austria More articles by this author , Martin PichlerMartin Pichler Graz, Austria More articles by this author , Thomas F. ChromeckiThomas F. Chromecki Graz, Austria More articles by this author , Johanna JescheJohanna Jesche Graz, Austria More articles by this author , Karin Kampel-KettnerKarin Kampel-Kettner Graz, Austria More articles by this author , Karl PummerKarl Pummer Graz, Austria More articles by this author , and Richard ZigeunerRichard Zigeuner Graz, Austria More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.783AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A new version of the TNM classification system for renal cell carcinoma (RCC) has been introduced in 2010 by the American Joint Committee on Cancer (AJCC). However, data for it's ability to predict metastasis-free survival in RCC patients from validation studies of independent cohorts are sparse. Therefore, we decided to compare the predictive ability of the 2010 vs. the 2002 version of the TNM classification system. METHODS Pathological reports of 2595 patients with uni- or bilateral synchronous non-metastatic (pT1-4N0M0) RCCs, treated with radical nephrectomy or nephron sparing surgery between 1984 and 2010 at a single tertiary academic center, were re-evaluated. Metastasis-free survival (MFS) was assessed using the Kaplan-Meier method and pairwise log-rank tests. RESULTS Mean follow up was 95 (0-322) months and 430 (16.6%) patients were found to develop metastatic disease from RCC. Pairwise comparisons revealed statistically significant differences in MFS between adjacent 2002 primary tumor classifications, including pT1a vs. pT1b (p<0.001), pT1b vs. pT2 (p=0.029), pT3a vs. pT3b (p<0.001), and pT3c vs. pT4 (p=0.007) but excluding, pT2 vs. pT3a (p=0.963) and pT3b vs. pT3c (p=0.968). With the changes to the 2010 primary tumor classification different trends in statistical significance were observed in pairwise comparisons, including pT1a vs. pT1b (p<0.001), pT3a vs. pT3b (p=0.001) but excluding pT1b vs. pT2a (p=0.062), pT2a vs. pT2b (p=0.856), pT2b vs. pT3a (p=0.395), pT3b vs. pT3c (p=0.891) and pT3c vs. pT4 (p=0.933). CONCLUSIONS The 2010 version of the TNM classification system remains a robust predictor of MFS compared to the 2002 version. However, the 2010 version showed less discriminative power in higher pT-stages compared to the 2002 version of the TNM classification system. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e286 Peer Review Report Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Georg C. Hutterer Graz, Austria More articles by this author Martin Pichler Graz, Austria More articles by this author Thomas F. Chromecki Graz, Austria More articles by this author Johanna Jesche Graz, Austria More articles by this author Karin Kampel-Kettner Graz, Austria More articles by this author Karl Pummer Graz, Austria More articles by this author Richard Zigeuner Graz, Austria More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2088948086 title "699 COMPARISON OF THE 2002 AND 2010 TNM CLASSIFICATION SYSTEM REGARDING THE PREDICTION OF METASTASIS-FREE SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA" @default.
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