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• W2088960975 abstract "Selective genetic manipulation of neuronal function in vivo requires techniques for targeting gene expression to specific cells. Existing systems accomplish this using the promoters of endogenous genes to drive expression of transgenes directly in cells of interest or, in binary systems, to drive expression of a transcription factor or recombinase that subsequently activates the expression of other transgenes. All such techniques are constrained by the limited specificity of the available promoters. We introduce here a combinatorial system in which the DNA-binding (DBD) and transcription-activation (AD) domains of a transcription factor are independently targeted using two different promoters. The domains heterodimerize to become transcriptionally competent and thus drive transgene expression only at the intersection of the expression patterns of the two promoters. We use this system to dissect a neuronal network in Drosophila by selectively targeting expression of the cell death gene reaper to subsets of neurons within the network." @default.
• W2088960975 created "2016-06-24" @default.
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• W2088960975 date "2006-11-01" @default.
• W2088960975 modified "2023-10-17" @default.
• W2088960975 title "Refined Spatial Manipulation of Neuronal Function by Combinatorial Restriction of Transgene Expression" @default.
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• W2088960975 doi "https://doi.org/10.1016/j.neuron.2006.08.028" @default.
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