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- W2088967544 abstract "A class of prenylated indole diketopiperazine alkaloids including 15 new compounds namely rubrumlines A-O obtained from marine-derived fungus Eurotium rubrum, were tested against influenza A/WSN/33 virus. Neoechinulin B (18) exerted potent inhibition against H1N1 virus infected in MDCK cells, and is able to inhibit a panel of influenza virus strains including amantadine- and oseltamivir-resistant clinical isolates. Mechanism of action studies indicated that neoechinulin B binds to influenza envelope hemagglutinin, disrupting its interaction with the sialic acid receptor and the attachment of viruses to host cells. In addition, neoechinulin B was still efficient in inhibiting influenza A/WSN/33 virus propagation even after a fifth passage. The high potency and broad-spectrum activities against influenza viruses with less drug resistance make neoechinulin B as a new lead for the development of potential inhibitor of influenza viruses." @default.
- W2088967544 created "2016-06-24" @default.
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- W2088967544 date "2015-03-01" @default.
- W2088967544 modified "2023-10-14" @default.
- W2088967544 title "Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin" @default.
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- W2088967544 doi "https://doi.org/10.1016/j.ejmech.2015.02.006" @default.
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