FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088972732> ?p ?o ?g. }

• W2088972732 endingPage "7932" @default.
• W2088972732 startingPage "7927" @default.
• W2088972732 abstract "Pancreatic proteases in the duodenum inhibit the release of cholecystokinin (CCK) and thus exert feedback control of pancreatic exocrine secretion. Exclusion of proteases from the duodenum either by the diversion of bile-pancreatic juice or by the addition of protease inhibitors stimulates exocrine pancreatic secretion. The mechanism by which pancreatic proteases in the duodenum regulate CCK secretion is unknown. In this study, we isolated a trypsin-sensitive peptide that is secreted intraduodenally, releases CCK, and stimulates pancreatic enzyme secretion in rats. This peptide was found to be identical to the porcine diazepam binding inhibitor by peptide sequencing and mass spectrometry analysis. Intraduodenal infusion of 200 ng of synthetic porcine diazepam binding inhibitor1-86 in rats significantly stimulated pancreatic amylase output. Infusion of the CCK antagonist MK-329 completely blocked the diazepam binding inhibitor-stimulated amylase secretion. Similarly, diazepam binding inhibitor33-52 [corrected] also stimulated CCK release and pancreatic secretion in a dose-dependent manner although it was 100 times less potent than the whole peptide. Using a perfusion system containing isolated mucosal cells from the proximal intestine of rats, porcine diazepam binding inhibitor 10(-12) M) dose dependently stimulated CCK secretion. In separate studies, it was demonstrated that luminal secretion of the diazepam binding inhibitor immunoreactivity (7.5 X 10(11) M) could be detected in rat's intestinal washing following the diversion of bile-pancreatic juice. The secretion of this peptide was inhibited by atropine. In conclusion, we have isolated and characterized a CCK-releasing peptide that has a sequence identical to the porcine diazepam binding inhibitor from pig intestinal mucosa and that stimulates CCK release when administered intraduodenally in rat. This peptide may mediate feedback regulation of pancreatic enzyme secretion." @default.
• W2088972732 created "2016-06-24" @default.
• W2088972732 creator A5001682422 @default.
• W2088972732 creator A5019403795 @default.
• W2088972732 creator A5028129169 @default.
• W2088972732 creator A5046097873 @default.
• W2088972732 creator A5075461994 @default.
• W2088972732 creator A5076273573 @default.
• W2088972732 creator A5086272334 @default.
• W2088972732 date "1996-07-23" @default.
• W2088972732 modified "2023-10-17" @default.
• W2088972732 title "Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine." @default.
• W2088972732 cites W119601619 @default.
• W2088972732 cites W133108889 @default.
• W2088972732 cites W1569429113 @default.
• W2088972732 cites W1585176981 @default.
• W2088972732 cites W1875830404 @default.
• W2088972732 cites W1975152935 @default.
• W2088972732 cites W1985767884 @default.
• W2088972732 cites W1999227915 @default.
• W2088972732 cites W2000033762 @default.
• W2088972732 cites W2006000052 @default.
• W2088972732 cites W2012648729 @default.
• W2088972732 cites W2013632322 @default.
• W2088972732 cites W2033829608 @default.
• W2088972732 cites W2035186682 @default.
• W2088972732 cites W2038673053 @default.
• W2088972732 cites W2056249844 @default.
• W2088972732 cites W2080359769 @default.
• W2088972732 cites W2084850584 @default.
• W2088972732 cites W2092015752 @default.
• W2088972732 cites W2092411410 @default.
• W2088972732 cites W2096357732 @default.
• W2088972732 cites W2111877204 @default.
• W2088972732 cites W2128635872 @default.
• W2088972732 cites W2196965313 @default.
• W2088972732 cites W2273674197 @default.
• W2088972732 cites W2332812403 @default.
• W2088972732 cites W2333999038 @default.
• W2088972732 cites W2341567212 @default.
• W2088972732 cites W2341670614 @default.
• W2088972732 cites W2399281501 @default.
• W2088972732 cites W266957110 @default.
• W2088972732 doi "https://doi.org/10.1073/pnas.93.15.7927" @default.
• W2088972732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38851" @default.
• W2088972732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8755579" @default.
• W2088972732 hasPublicationYear "1996" @default.
• W2088972732 type Work @default.
• W2088972732 sameAs 2088972732 @default.
• W2088972732 citedByCount "97" @default.
• W2088972732 countsByYear W20889727322012 @default.
• W2088972732 countsByYear W20889727322013 @default.
• W2088972732 countsByYear W20889727322014 @default.
• W2088972732 countsByYear W20889727322015 @default.
• W2088972732 countsByYear W20889727322016 @default.
• W2088972732 countsByYear W20889727322017 @default.
• W2088972732 countsByYear W20889727322018 @default.
• W2088972732 countsByYear W20889727322020 @default.
• W2088972732 countsByYear W20889727322021 @default.
• W2088972732 countsByYear W20889727322023 @default.
• W2088972732 crossrefType "journal-article" @default.
• W2088972732 hasAuthorship W2088972732A5001682422 @default.
• W2088972732 hasAuthorship W2088972732A5019403795 @default.
• W2088972732 hasAuthorship W2088972732A5028129169 @default.
• W2088972732 hasAuthorship W2088972732A5046097873 @default.
• W2088972732 hasAuthorship W2088972732A5075461994 @default.
• W2088972732 hasAuthorship W2088972732A5076273573 @default.
• W2088972732 hasAuthorship W2088972732A5086272334 @default.
• W2088972732 hasBestOaLocation W20889727322 @default.
• W2088972732 hasConcept C126322002 @default.
• W2088972732 hasConcept C134018914 @default.
• W2088972732 hasConcept C170493617 @default.
• W2088972732 hasConcept C181199279 @default.
• W2088972732 hasConcept C182220744 @default.
• W2088972732 hasConcept C185592680 @default.
• W2088972732 hasConcept C2776175493 @default.
• W2088972732 hasConcept C2776809568 @default.
• W2088972732 hasConcept C2777593968 @default.
• W2088972732 hasConcept C2777951760 @default.
• W2088972732 hasConcept C2778764654 @default.
• W2088972732 hasConcept C2779281246 @default.
• W2088972732 hasConcept C32110497 @default.
• W2088972732 hasConcept C49039625 @default.
• W2088972732 hasConcept C55493867 @default.
• W2088972732 hasConcept C56191518 @default.
• W2088972732 hasConcept C57380142 @default.
• W2088972732 hasConcept C71924100 @default.
• W2088972732 hasConcept C86803240 @default.
• W2088972732 hasConcept C98274493 @default.
• W2088972732 hasConceptScore W2088972732C126322002 @default.
• W2088972732 hasConceptScore W2088972732C134018914 @default.
• W2088972732 hasConceptScore W2088972732C170493617 @default.
• W2088972732 hasConceptScore W2088972732C181199279 @default.
• W2088972732 hasConceptScore W2088972732C182220744 @default.
• W2088972732 hasConceptScore W2088972732C185592680 @default.
• W2088972732 hasConceptScore W2088972732C2776175493 @default.
• W2088972732 hasConceptScore W2088972732C2776809568 @default.
• W2088972732 hasConceptScore W2088972732C2777593968 @default.

• next