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• W2088976722 startingPage "779" @default.
• W2088976722 abstract "The insulin-like growth factor (IGF) autocrine/paracrine system is believed to play a role in endometrial differentiation and trophoblast growth. The IGFs bind with high affinity to a family of binding proteins (IGFBPs) that regulate the actions of the IGFs at their target cells. IGFBP-1, one of three well-characterized IGFBPs in humans, has been shown by numerous investigators to be present in secretory but not proliferative endometrium; however, no information is available with regard to two other human IGFBPs, IGFBP-2 and IGFBP-3, in normal human endometrium. We have examined expression of the messenger RNAs (mRNAs) encoding IGFBP-2 and IGFBP-3 in human proliferative endometrium [under the influence of estradiol (E2)] compared to secretory endometrium (under the influence of E2 and progesterone). Using a complementary DNA probe specific for IGFBP-2, by Northern analysis, expression of a 1.4 kilobase mRNA was found to be differentially expressed in secretory compared to proliferative phase endometrium. Using a complementary DNA probe encoding IGFBP-3, a 2.4 kilobase mRNA was found in endometrium and was also found to be differentially expressed in secretory compared to proliferative phase endometrium. Endometrial stromal cells were established in culture and revealed constitutive synthesis and secretion of IGFBP-2 and IGFBP-3 into the conditioned medium (CM), as detected by Western ligand blot analysis of the CM. Identification of the IGFBPs in the CM was made using IGFBP-2 and IGFBP-3 specific antiserum. In the presence of E2 and progesterone, there was an enhancement in the amount of IGFBP-3 and a marked enhancement of IGFBP-2 in the conditioned media, suggesting sex steroid-dependence of IGFBP-2 and, to a lesser extent, IGFBP-3 protein synthesis. Western ligand blot analysis of IGFBPs in serum throughout the menstrual cycle revealed no hormonal dependence in the serum IGFBPs, suggesting local action of the IGFBPs in endometrium. These data thus show that mRNAs encoding IGFBP-2 and IGFBP-3 are expressed in human endometrium, that their expression is differentially regulated in secretory compared to proliferative phase endometrium (different steroidogenic environments), and that the synthesis of both IGFBP-2 and IGFBP-3 proteins is regulated by steroid hormones." @default.
• W2088976722 created "2016-06-24" @default.
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• W2088976722 date "1991-04-01" @default.
• W2088976722 modified "2023-10-14" @default.
• W2088976722 title "Insulin-Like Growth Factor Binding Proteins in Human Endometrium: Steroid-Dependent Messenger Ribonucleic Acid Expression and Protein Synthesis*" @default.
• W2088976722 cites W1451684643 @default.
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• W2088976722 cites W1603507130 @default.
• W2088976722 cites W1791368090 @default.
• W2088976722 cites W1795675730 @default.
• W2088976722 cites W1805894306 @default.
• W2088976722 cites W1828467840 @default.
• W2088976722 cites W1967723511 @default.
• W2088976722 cites W1968036473 @default.
• W2088976722 cites W1969770404 @default.
• W2088976722 cites W1972819401 @default.
• W2088976722 cites W1974776814 @default.
• W2088976722 cites W1976440273 @default.
• W2088976722 cites W1981434344 @default.
• W2088976722 cites W1985220842 @default.
• W2088976722 cites W1985722532 @default.
• W2088976722 cites W1987568997 @default.
• W2088976722 cites W1988028901 @default.
• W2088976722 cites W1989954569 @default.
• W2088976722 cites W1992535920 @default.
• W2088976722 cites W1995535256 @default.
• W2088976722 cites W2001229549 @default.
• W2088976722 cites W2003016121 @default.
• W2088976722 cites W2007669034 @default.
• W2088976722 cites W2008115139 @default.
• W2088976722 cites W2010371903 @default.
• W2088976722 cites W2011608152 @default.
• W2088976722 cites W2011836510 @default.
• W2088976722 cites W2011917733 @default.
• W2088976722 cites W2013725492 @default.
• W2088976722 cites W2018005226 @default.
• W2088976722 cites W2022958582 @default.
• W2088976722 cites W2023698107 @default.
• W2088976722 cites W2025978251 @default.
• W2088976722 cites W2026397471 @default.
• W2088976722 cites W2028845379 @default.
• W2088976722 cites W2032558447 @default.
• W2088976722 cites W2034816153 @default.
• W2088976722 cites W2041108328 @default.
• W2088976722 cites W2041168033 @default.
• W2088976722 cites W2043451798 @default.
• W2088976722 cites W2044472384 @default.
• W2088976722 cites W2044720543 @default.
• W2088976722 cites W2045206229 @default.
• W2088976722 cites W2049749719 @default.
• W2088976722 cites W2058983784 @default.
• W2088976722 cites W2062750316 @default.
• W2088976722 cites W2066727844 @default.
• W2088976722 cites W2068659303 @default.
• W2088976722 cites W2069819021 @default.
• W2088976722 cites W2079511162 @default.
• W2088976722 cites W2079586703 @default.
• W2088976722 cites W2081075932 @default.
• W2088976722 cites W2084310213 @default.
• W2088976722 cites W2086955288 @default.
• W2088976722 cites W2088986997 @default.
• W2088976722 cites W2097980511 @default.
• W2088976722 cites W2108230936 @default.
• W2088976722 cites W2114828069 @default.
• W2088976722 cites W2140204001 @default.
• W2088976722 cites W2163338862 @default.
• W2088976722 cites W2163817240 @default.
• W2088976722 cites W221421711 @default.
• W2088976722 cites W2241768283 @default.
• W2088976722 cites W2398193543 @default.
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• W2088976722 doi "https://doi.org/10.1210/jcem-72-4-779" @default.
• W2088976722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1706350" @default.
• W2088976722 hasPublicationYear "1991" @default.
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