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- W2088978086 abstract "Abstract Analogs of the monocyclic β-lactam human leukocyte elastase (HLE) inhibitor L-680,833 in which the carboxyl group is replaced by phosphorous acid moieties were synthesized and found to be potent inhibitors of the enzyme ( k inact / K i in the range 217,000–1,326,000 M −1 s −1 ). Cellular activity was demonstrated by inhibition of the generation of the N-terminal cleavage product Aα-(1–21) from the Aα chain of fibrinogen." @default.
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- W2088978086 date "1995-02-01" @default.
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- W2088978086 title "Phosphorous acid analogs of L-680,833, a potent monocyclic β-lactam inhibitor of human leukocyte elastase" @default.
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- W2088978086 doi "https://doi.org/10.1016/0960-894x(95)00022-l" @default.
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