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- W2088978129 abstract "BackgroundEmerging research has identified the endothelin (ET)-1 pathway as a potential target for novel renoprotective therapies. We recently showed that selective ET-A receptor antagonism in chronic renovascular disease (RVD) improves renal function and reduces renal injury. Although ET-A and -B have opposing roles, in some clinical situations they may induce similar effects. Thus, we hypothesized that simultaneous blockade of the ET-A and -B receptors would protect the kidney during RVD." @default.
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- W2088978129 date "2014-11-21" @default.
- W2088978129 modified "2023-09-26" @default.
- W2088978129 title "Chronic blockade of endothelin A and B receptors using macitentan in experimental renovascular disease" @default.
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- W2088978129 doi "https://doi.org/10.1093/ndt/gfu361" @default.
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