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- W2088984244 abstract "F UNCTIONING adrenal carcinomas, while rare, may present a formidable problem in management unless complete surgical removal can be accomplished [7-d]. Such tumors respond poorly to radiation [5,6] or chemotherapy [6]. Experimental work has shown that some endocrine tumors may develop or are maintained by hypersecretion of the pituitary trophic hormones [7]. In man, carcinomas of the thyroid appear to grow most rapidly when thyrothrophin production remains high [S]. On the other hand, most adrenal carcinomas have not seemed to be responsive to corticotrophin [9,10], although in some patients a rise in hormone output has been evoked by ACTH [70-721. The few attempts to control adrenal tumors by hypophysectomy have been disappointing [ 73,741. The possibility of control of the metabolic action of functioning tumors with pharmacologic agents has come under examination with the availability of amphenone, (3,3-di (p-aminophenyl) butanone-2-dihydrochloride), which blocks the production of corticosteroids in animals and man [75-791, and which leads to enlargement of the adrenal cortex and to lipid accumulation in the cells of the zonae fasciculata and reticularis in the presence of the intact pituitary [75,78]. Suppression of synthesis of both C-19 and C-21 compounds by addition of amphenone to perfused calf adrenals has also been demonstrated [B]. Inhibition of corticosteroid production by amphenone has been clearly established in patients with adrenal carcinomas [6,79]. Toxic manifestations have included drowsiness, gastrointestinal symptoms and methemoglobinemia [ 781. The possible benefit to be realized from hypophysectomy, chemotherapy and amphenone treatment was investigated in a girl whose adrenal tumor had recurred after surgical removal had been attempted." @default.
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- W2088984244 date "1958-03-01" @default.
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- W2088984244 title "Effects of hypophysectomy and of amphenone administration in a child with functioning metastatic adrenal carcinoma" @default.
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- W2088984244 doi "https://doi.org/10.1016/0002-9343(58)90335-8" @default.
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