Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088984898> ?p ?o ?g. }
- W2088984898 abstract "We tested a set of boron containing arylethanolamine derivatives on the human and guinea pig β(2) adrenoceptor (β(2)AR) 3-D structures by docking methodology. The compound with the highest affinity based on docking analysis, (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate (boronterol) was synthesized, characterized and tested in guinea pig tracheal rings at basal tone and with histamine-induced contractions. Boronterol was at least eightfold more potent than salbutamol as a smooth muscle relaxant drug (judged by the EC(50) values) and showed a similar maximal relaxant effect as isoproterenol. ICI118,551 showed competitive antagonism on the relaxing effect of boronterol. These results suggest the β(2)AR agonist action of boronterol." @default.
- W2088984898 created "2016-06-24" @default.
- W2088984898 creator A5041724997 @default.
- W2088984898 creator A5045628582 @default.
- W2088984898 creator A5049669228 @default.
- W2088984898 creator A5070451157 @default.
- W2088984898 creator A5074014733 @default.
- W2088984898 creator A5090463598 @default.
- W2088984898 date "2010-10-01" @default.
- W2088984898 modified "2023-10-16" @default.
- W2088984898 title "Design, synthesis and in vitro evaluation of (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate: A novel salbutamol derivative with high intrinsic efficacy on the β2 adrenoceptor" @default.
- W2088984898 cites W1825353903 @default.
- W2088984898 cites W1862886500 @default.
- W2088984898 cites W1964543134 @default.
- W2088984898 cites W1964626085 @default.
- W2088984898 cites W1969377155 @default.
- W2088984898 cites W1974385832 @default.
- W2088984898 cites W1981636172 @default.
- W2088984898 cites W1988284754 @default.
- W2088984898 cites W1990813403 @default.
- W2088984898 cites W2002215104 @default.
- W2088984898 cites W2026020719 @default.
- W2088984898 cites W2026338485 @default.
- W2088984898 cites W2029667189 @default.
- W2088984898 cites W2035986257 @default.
- W2088984898 cites W2040428071 @default.
- W2088984898 cites W2042183897 @default.
- W2088984898 cites W2046754487 @default.
- W2088984898 cites W2054394185 @default.
- W2088984898 cites W2057479824 @default.
- W2088984898 cites W2072735940 @default.
- W2088984898 cites W2080653934 @default.
- W2088984898 cites W2080907024 @default.
- W2088984898 cites W2091367130 @default.
- W2088984898 cites W2092757199 @default.
- W2088984898 cites W2100201978 @default.
- W2088984898 cites W2104477830 @default.
- W2088984898 cites W2136009931 @default.
- W2088984898 cites W2140690192 @default.
- W2088984898 cites W2147347393 @default.
- W2088984898 cites W2147500953 @default.
- W2088984898 cites W2155346762 @default.
- W2088984898 cites W2157562973 @default.
- W2088984898 cites W2158534713 @default.
- W2088984898 cites W2162817259 @default.
- W2088984898 cites W2168833646 @default.
- W2088984898 doi "https://doi.org/10.1016/j.bmcl.2010.08.040" @default.
- W2088984898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20805027" @default.
- W2088984898 hasPublicationYear "2010" @default.
- W2088984898 type Work @default.
- W2088984898 sameAs 2088984898 @default.
- W2088984898 citedByCount "13" @default.
- W2088984898 countsByYear W20889848982012 @default.
- W2088984898 countsByYear W20889848982013 @default.
- W2088984898 countsByYear W20889848982014 @default.
- W2088984898 countsByYear W20889848982015 @default.
- W2088984898 countsByYear W20889848982017 @default.
- W2088984898 countsByYear W20889848982018 @default.
- W2088984898 crossrefType "journal-article" @default.
- W2088984898 hasAuthorship W2088984898A5041724997 @default.
- W2088984898 hasAuthorship W2088984898A5045628582 @default.
- W2088984898 hasAuthorship W2088984898A5049669228 @default.
- W2088984898 hasAuthorship W2088984898A5070451157 @default.
- W2088984898 hasAuthorship W2088984898A5074014733 @default.
- W2088984898 hasAuthorship W2088984898A5090463598 @default.
- W2088984898 hasConcept C1122143 @default.
- W2088984898 hasConcept C126322002 @default.
- W2088984898 hasConcept C159110408 @default.
- W2088984898 hasConcept C170493617 @default.
- W2088984898 hasConcept C185592680 @default.
- W2088984898 hasConcept C202751555 @default.
- W2088984898 hasConcept C2776042228 @default.
- W2088984898 hasConcept C2777394947 @default.
- W2088984898 hasConcept C2778815084 @default.
- W2088984898 hasConcept C2778938600 @default.
- W2088984898 hasConcept C2780591741 @default.
- W2088984898 hasConcept C41685203 @default.
- W2088984898 hasConcept C55493867 @default.
- W2088984898 hasConcept C71240020 @default.
- W2088984898 hasConcept C71924100 @default.
- W2088984898 hasConcept C98274493 @default.
- W2088984898 hasConceptScore W2088984898C1122143 @default.
- W2088984898 hasConceptScore W2088984898C126322002 @default.
- W2088984898 hasConceptScore W2088984898C159110408 @default.
- W2088984898 hasConceptScore W2088984898C170493617 @default.
- W2088984898 hasConceptScore W2088984898C185592680 @default.
- W2088984898 hasConceptScore W2088984898C202751555 @default.
- W2088984898 hasConceptScore W2088984898C2776042228 @default.
- W2088984898 hasConceptScore W2088984898C2777394947 @default.
- W2088984898 hasConceptScore W2088984898C2778815084 @default.
- W2088984898 hasConceptScore W2088984898C2778938600 @default.
- W2088984898 hasConceptScore W2088984898C2780591741 @default.
- W2088984898 hasConceptScore W2088984898C41685203 @default.
- W2088984898 hasConceptScore W2088984898C55493867 @default.
- W2088984898 hasConceptScore W2088984898C71240020 @default.
- W2088984898 hasConceptScore W2088984898C71924100 @default.
- W2088984898 hasConceptScore W2088984898C98274493 @default.
- W2088984898 hasLocation W20889848981 @default.
- W2088984898 hasLocation W20889848982 @default.
- W2088984898 hasOpenAccess W2088984898 @default.