FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088987673> ?p ?o ?g. }

• W2088987673 endingPage "56" @default.
• W2088987673 startingPage "44" @default.
• W2088987673 abstract "Summary: V, D, and J gene segments rearrange at very different frequencies. As with most biological systems, there are multiple levels of control of V gene recombination frequency, and here we review some of the work from our laboratory that addresses these various control mechanisms. One of the important factors that affect non‐random V gene rearrangement frequency is the natural heterogeneity in recombination signal sequences (RSSs). Not only does variation in the heptamer and nonamer affect rearrangement, but variation in the spacer can also dramatically affect recombination. However, there are clearly other factors which control V gene rearrangement, as revealed by the fact that genes with identical RSSs can rearrange at different frequencies in vivo . Some of these other influences most likely affect the earliest stages of control – the change from an inaccessible state to an accessible state. Transcription factors can play a role in inducing these changes. Rearrangement of many VκI genes can be induced in a non‐lymphoid cell line after ectopic expression of E2A, while neighboring VκII and VκIII genes do not rearrange, demonstrating that at least one level of control of induction of accessibility occurs at the level of the individual gene. Also, changes in chromatin structure can affect accessibility and might influence individual V gene rearrangement frequency." @default.
• W2088987673 created "2016-06-24" @default.
• W2088987673 creator A5024259119 @default.
• W2088987673 creator A5039510614 @default.
• W2088987673 creator A5082846382 @default.
• W2088987673 date "2004-07-09" @default.
• W2088987673 modified "2023-10-16" @default.
• W2088987673 title "Many levels of control of V gene rearrangement frequency" @default.
• W2088987673 cites W102635869 @default.
• W2088987673 cites W1486858179 @default.
• W2088987673 cites W1496680764 @default.
• W2088987673 cites W1497130717 @default.
• W2088987673 cites W1502641732 @default.
• W2088987673 cites W1510972797 @default.
• W2088987673 cites W1556273434 @default.
• W2088987673 cites W1575299344 @default.
• W2088987673 cites W1595674107 @default.
• W2088987673 cites W1670107136 @default.
• W2088987673 cites W1896423162 @default.
• W2088987673 cites W1919334117 @default.
• W2088987673 cites W1925554218 @default.
• W2088987673 cites W1966254031 @default.
• W2088987673 cites W1966880762 @default.
• W2088987673 cites W1968561263 @default.
• W2088987673 cites W1969499881 @default.
• W2088987673 cites W1970693469 @default.
• W2088987673 cites W1976427656 @default.
• W2088987673 cites W1977833662 @default.
• W2088987673 cites W1984387553 @default.
• W2088987673 cites W1992825055 @default.
• W2088987673 cites W2006573531 @default.
• W2088987673 cites W2007138237 @default.
• W2088987673 cites W2007559212 @default.
• W2088987673 cites W2018107989 @default.
• W2088987673 cites W2019314826 @default.
• W2088987673 cites W2022366037 @default.
• W2088987673 cites W2022372517 @default.
• W2088987673 cites W2022486030 @default.
• W2088987673 cites W2026602476 @default.
• W2088987673 cites W2032414205 @default.
• W2088987673 cites W2032960386 @default.
• W2088987673 cites W2035502959 @default.
• W2088987673 cites W2036050361 @default.
• W2088987673 cites W2036331912 @default.
• W2088987673 cites W2041348782 @default.
• W2088987673 cites W2042050831 @default.
• W2088987673 cites W2047012085 @default.
• W2088987673 cites W2050390687 @default.
• W2088987673 cites W2052274930 @default.
• W2088987673 cites W2052774548 @default.
• W2088987673 cites W2057140180 @default.
• W2088987673 cites W2058660996 @default.
• W2088987673 cites W2068012172 @default.
• W2088987673 cites W2068660936 @default.
• W2088987673 cites W2070743892 @default.
• W2088987673 cites W2072807977 @default.
• W2088987673 cites W2077311610 @default.
• W2088987673 cites W2080686406 @default.
• W2088987673 cites W2087604899 @default.
• W2088987673 cites W2087707939 @default.
• W2088987673 cites W2089836142 @default.
• W2088987673 cites W2095163547 @default.
• W2088987673 cites W2096313716 @default.
• W2088987673 cites W2099719096 @default.
• W2088987673 cites W2106188260 @default.
• W2088987673 cites W2108926544 @default.
• W2088987673 cites W2117789925 @default.
• W2088987673 cites W2118107917 @default.
• W2088987673 cites W2124136984 @default.
• W2088987673 cites W2125622789 @default.
• W2088987673 cites W2134759974 @default.
• W2088987673 cites W2140336226 @default.
• W2088987673 cites W2142923239 @default.
• W2088987673 cites W2147683057 @default.
• W2088987673 cites W2154029983 @default.
• W2088987673 cites W2158364488 @default.
• W2088987673 cites W2159241107 @default.
• W2088987673 cites W2163584800 @default.
• W2088987673 cites W2165057782 @default.
• W2088987673 cites W2166988166 @default.
• W2088987673 cites W4300705317 @default.
• W2088987673 cites W4313341505 @default.
• W2088987673 cites W4313343486 @default.
• W2088987673 doi "https://doi.org/10.1111/j.0105-2896.2004.00163.x" @default.
• W2088987673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15242395" @default.
• W2088987673 hasPublicationYear "2004" @default.
• W2088987673 type Work @default.
• W2088987673 sameAs 2088987673 @default.
• W2088987673 citedByCount "39" @default.
• W2088987673 countsByYear W20889876732013 @default.
• W2088987673 countsByYear W20889876732015 @default.
• W2088987673 countsByYear W20889876732016 @default.
• W2088987673 countsByYear W20889876732017 @default.
• W2088987673 countsByYear W20889876732018 @default.
• W2088987673 countsByYear W20889876732019 @default.
• W2088987673 countsByYear W20889876732020 @default.
• W2088987673 countsByYear W20889876732021 @default.
• W2088987673 countsByYear W20889876732022 @default.

• next