Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088988299> ?p ?o ?g. }
- W2088988299 endingPage "298" @default.
- W2088988299 startingPage "289" @default.
- W2088988299 abstract "Addition of mineralocorticoid receptor (MR) antagonists to standard therapy for heart failure, kidney disease, metabolic syndrome, and diabetes is increasing steadily in response to clinical trials demonstrating clear benefits. In addition to blocking deleterious activity of MR within the heart, vessels and kidneys, MR antagonists target MR in hemodynamic regulatory centers in the brain, thereby decreasing excessive sympathetic nervous system drive, vasopressin release, abnormal baroreceptor function, and circulating and tissue pro-inflammatory cytokines. However, brain MR are also involved with cognition, memory, affect and functions yet to be determined. Understanding specific central mechanisms involved in blood pressure regulation by MR is necessary for the development of agents to target downstream events specific to central hemodynamic regulation, not only to avoid the hypokalemia caused by inhibition of renal tubular MR, but also to avoid untoward long term effects of inhibiting brain MR that are not involved in blood pressure control." @default.
- W2088988299 created "2016-06-24" @default.
- W2088988299 creator A5024989958 @default.
- W2088988299 creator A5044042051 @default.
- W2088988299 date "2012-03-01" @default.
- W2088988299 modified "2023-10-02" @default.
- W2088988299 title "Central regulation of blood pressure by the mineralocorticoid receptor" @default.
- W2088988299 cites W117282844 @default.
- W2088988299 cites W1484991080 @default.
- W2088988299 cites W1536138982 @default.
- W2088988299 cites W1623823475 @default.
- W2088988299 cites W1856509968 @default.
- W2088988299 cites W1906401678 @default.
- W2088988299 cites W1965010499 @default.
- W2088988299 cites W1966308039 @default.
- W2088988299 cites W1968598082 @default.
- W2088988299 cites W1969160852 @default.
- W2088988299 cites W1969194630 @default.
- W2088988299 cites W1975732424 @default.
- W2088988299 cites W1976289196 @default.
- W2088988299 cites W1977633992 @default.
- W2088988299 cites W1978937183 @default.
- W2088988299 cites W1979022882 @default.
- W2088988299 cites W1979178661 @default.
- W2088988299 cites W1979939318 @default.
- W2088988299 cites W1980583333 @default.
- W2088988299 cites W1981893923 @default.
- W2088988299 cites W1986937962 @default.
- W2088988299 cites W1987619509 @default.
- W2088988299 cites W1988278754 @default.
- W2088988299 cites W1990746263 @default.
- W2088988299 cites W1993704473 @default.
- W2088988299 cites W1995065492 @default.
- W2088988299 cites W1997737209 @default.
- W2088988299 cites W1997775090 @default.
- W2088988299 cites W1998089491 @default.
- W2088988299 cites W1999445328 @default.
- W2088988299 cites W2001546197 @default.
- W2088988299 cites W2002009078 @default.
- W2088988299 cites W2002209524 @default.
- W2088988299 cites W2006236410 @default.
- W2088988299 cites W2008553662 @default.
- W2088988299 cites W2009971000 @default.
- W2088988299 cites W2010743737 @default.
- W2088988299 cites W2011896070 @default.
- W2088988299 cites W2012887800 @default.
- W2088988299 cites W2013521729 @default.
- W2088988299 cites W2018184863 @default.
- W2088988299 cites W2021688937 @default.
- W2088988299 cites W2021739252 @default.
- W2088988299 cites W2022393522 @default.
- W2088988299 cites W2022933863 @default.
- W2088988299 cites W2023844410 @default.
- W2088988299 cites W2026362575 @default.
- W2088988299 cites W2026367402 @default.
- W2088988299 cites W2026975881 @default.
- W2088988299 cites W2028732654 @default.
- W2088988299 cites W2029012272 @default.
- W2088988299 cites W2030869721 @default.
- W2088988299 cites W2031799890 @default.
- W2088988299 cites W2032452762 @default.
- W2088988299 cites W2032789757 @default.
- W2088988299 cites W2033296244 @default.
- W2088988299 cites W2034262643 @default.
- W2088988299 cites W2035037043 @default.
- W2088988299 cites W2036574905 @default.
- W2088988299 cites W2041396668 @default.
- W2088988299 cites W2043991553 @default.
- W2088988299 cites W2047436864 @default.
- W2088988299 cites W2050124762 @default.
- W2088988299 cites W2050546612 @default.
- W2088988299 cites W2052724934 @default.
- W2088988299 cites W2053797457 @default.
- W2088988299 cites W2056310243 @default.
- W2088988299 cites W2057432228 @default.
- W2088988299 cites W2057599373 @default.
- W2088988299 cites W2062134402 @default.
- W2088988299 cites W2063351772 @default.
- W2088988299 cites W2074901568 @default.
- W2088988299 cites W2078753195 @default.
- W2088988299 cites W2080697863 @default.
- W2088988299 cites W2081175312 @default.
- W2088988299 cites W2081967961 @default.
- W2088988299 cites W2084513455 @default.
- W2088988299 cites W2090748813 @default.
- W2088988299 cites W2091781256 @default.
- W2088988299 cites W2092182177 @default.
- W2088988299 cites W2095465583 @default.
- W2088988299 cites W2095721744 @default.
- W2088988299 cites W2104816422 @default.
- W2088988299 cites W2105265963 @default.
- W2088988299 cites W2106070650 @default.
- W2088988299 cites W2106478990 @default.
- W2088988299 cites W2108566684 @default.
- W2088988299 cites W2111284214 @default.
- W2088988299 cites W2111987861 @default.
- W2088988299 cites W2114213801 @default.
- W2088988299 cites W2114792114 @default.