Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088996957> ?p ?o ?g. }
- W2088996957 endingPage "665" @default.
- W2088996957 startingPage "660" @default.
- W2088996957 abstract "This study assessed the growth pattern, cellular organisation and chemosensitivity of established human tumour cell lines growing as postconfluent cultures in 'V'-bottomed, 96-well microtiter plates. Cross-sections of the colon (HT29, SW620, SW1116), ovarian (A2780) and head and neck (UM-SCC-22B) carcinoma microcultures allowed in situ evaluation of the cellular organisation in the wells. After 5 days of growth, every cell line had reached confluence, but each of them displayed a specific pattern of cell stacking which ranged from two to ten layers. Postconfluent HT29 cells displayed morphologic features suggestive of some degree of enterocytic differentiation. Growth and cytotoxicity could be studied reliably and reproducibly in this system with the sulforhodamine B protein assay. Against HT29 postconfluent cultures, the EC50's (drug concentrations producing absorbance readings 50% lower than those of non-treated wells) of 5-fluorouracil and of the ether lipid, hexadecylphosphocholine, were 1 mM and 50 microM respectively. The possibility to perform chemosensitivity tests using semiautomated microtiter plate technology supports further evaluation of this system as an alternative antitumour drug testing model." @default.
- W2088996957 created "2016-06-24" @default.
- W2088996957 creator A5005345775 @default.
- W2088996957 creator A5022063365 @default.
- W2088996957 creator A5035296183 @default.
- W2088996957 creator A5048552655 @default.
- W2088996957 creator A5061303688 @default.
- W2088996957 creator A5062035206 @default.
- W2088996957 creator A5063153124 @default.
- W2088996957 date "1992-10-01" @default.
- W2088996957 modified "2023-10-14" @default.
- W2088996957 title "Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates" @default.
- W2088996957 cites W1536544150 @default.
- W2088996957 cites W156159502 @default.
- W2088996957 cites W1597226951 @default.
- W2088996957 cites W1603652349 @default.
- W2088996957 cites W1732418055 @default.
- W2088996957 cites W1824326145 @default.
- W2088996957 cites W1875077626 @default.
- W2088996957 cites W1964243472 @default.
- W2088996957 cites W1992022488 @default.
- W2088996957 cites W2011031887 @default.
- W2088996957 cites W2012479775 @default.
- W2088996957 cites W2014412958 @default.
- W2088996957 cites W2018445338 @default.
- W2088996957 cites W2020686935 @default.
- W2088996957 cites W2021520796 @default.
- W2088996957 cites W2034649366 @default.
- W2088996957 cites W2041521207 @default.
- W2088996957 cites W2041585886 @default.
- W2088996957 cites W2054814252 @default.
- W2088996957 cites W2057642134 @default.
- W2088996957 cites W2077701957 @default.
- W2088996957 cites W2080624240 @default.
- W2088996957 cites W2109689528 @default.
- W2088996957 cites W2117308090 @default.
- W2088996957 cites W2118524296 @default.
- W2088996957 cites W2120064876 @default.
- W2088996957 cites W2135204805 @default.
- W2088996957 cites W2138079449 @default.
- W2088996957 cites W2138414301 @default.
- W2088996957 cites W2140844484 @default.
- W2088996957 cites W2143158861 @default.
- W2088996957 cites W2159296031 @default.
- W2088996957 cites W2398105680 @default.
- W2088996957 cites W2411810332 @default.
- W2088996957 cites W70091162 @default.
- W2088996957 doi "https://doi.org/10.1038/bjc.1992.333" @default.
- W2088996957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1977414" @default.
- W2088996957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1419603" @default.
- W2088996957 hasPublicationYear "1992" @default.
- W2088996957 type Work @default.
- W2088996957 sameAs 2088996957 @default.
- W2088996957 citedByCount "29" @default.
- W2088996957 countsByYear W20889969572013 @default.
- W2088996957 countsByYear W20889969572014 @default.
- W2088996957 countsByYear W20889969572016 @default.
- W2088996957 countsByYear W20889969572017 @default.
- W2088996957 countsByYear W20889969572021 @default.
- W2088996957 crossrefType "journal-article" @default.
- W2088996957 hasAuthorship W2088996957A5005345775 @default.
- W2088996957 hasAuthorship W2088996957A5022063365 @default.
- W2088996957 hasAuthorship W2088996957A5035296183 @default.
- W2088996957 hasAuthorship W2088996957A5048552655 @default.
- W2088996957 hasAuthorship W2088996957A5061303688 @default.
- W2088996957 hasAuthorship W2088996957A5062035206 @default.
- W2088996957 hasAuthorship W2088996957A5063153124 @default.
- W2088996957 hasBestOaLocation W20889969571 @default.
- W2088996957 hasConcept C109316439 @default.
- W2088996957 hasConcept C1491633281 @default.
- W2088996957 hasConcept C153911025 @default.
- W2088996957 hasConcept C185592680 @default.
- W2088996957 hasConcept C202751555 @default.
- W2088996957 hasConcept C2583947 @default.
- W2088996957 hasConcept C2776074239 @default.
- W2088996957 hasConcept C2778076430 @default.
- W2088996957 hasConcept C2778810118 @default.
- W2088996957 hasConcept C29537977 @default.
- W2088996957 hasConcept C43617362 @default.
- W2088996957 hasConcept C54355233 @default.
- W2088996957 hasConcept C55493867 @default.
- W2088996957 hasConcept C62112901 @default.
- W2088996957 hasConcept C64299311 @default.
- W2088996957 hasConcept C81885089 @default.
- W2088996957 hasConcept C86803240 @default.
- W2088996957 hasConceptScore W2088996957C109316439 @default.
- W2088996957 hasConceptScore W2088996957C1491633281 @default.
- W2088996957 hasConceptScore W2088996957C153911025 @default.
- W2088996957 hasConceptScore W2088996957C185592680 @default.
- W2088996957 hasConceptScore W2088996957C202751555 @default.
- W2088996957 hasConceptScore W2088996957C2583947 @default.
- W2088996957 hasConceptScore W2088996957C2776074239 @default.
- W2088996957 hasConceptScore W2088996957C2778076430 @default.
- W2088996957 hasConceptScore W2088996957C2778810118 @default.
- W2088996957 hasConceptScore W2088996957C29537977 @default.
- W2088996957 hasConceptScore W2088996957C43617362 @default.
- W2088996957 hasConceptScore W2088996957C54355233 @default.
- W2088996957 hasConceptScore W2088996957C55493867 @default.