FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088998237> ?p ?o ?g. }

• W2088998237 endingPage "1791" @default.
• W2088998237 startingPage "1785" @default.
• W2088998237 abstract "The issue of pharmacoresistance in epilepsy has received considerable attention in recent years, and a number of plausible hypotheses have been proposed. Of these, the so-called transporter hypothesis is the most extensively researched and documented. This hypothesis assumes that refractory epilepsy is associated with a localised over-expression of drug transporter proteins such as P-glycoprotein (Pgp) in the region of the epileptic focus, which actively extrudes antiepileptic drugs (AEDs) from their intended site of action. However, although this hypothesis has biological plausibility, there is no clinical evidence to support the assertion that AEDs are sufficiently strong substrates for transportermediated extrusion from the brain. The use of modern brain imaging techniques to determine Pgp function in patients with refractory epilepsy has started only recently, and may ultimately determine whether increased expression and function of Pgp or other efflux transporters are involved in AED resistance. Keywords: Multidrug transporters, antiepileptic drugs, brain imaging, positron emission tomography, verapamil, tariquidar, P-glycoprotein, Epilepsy, Antiepileptic drugs (AEDs), Erapamil, blood-brain barrier (BBB), CNS disorder, Temporal lobe epilepsy (TLE), Pgp expression, Single photon emission computed tomography (SPECT), Magnetic resonance spectroscopy (MRS), Radiotracers, Pgp substrates, [11C]daunorubicin, [11C]colchicine, [18F]paclitaxel, [11C]carvedilol, [11C]loperamide, [11C]-Ndesmethyl-loperamide, cyclosporin A (CsA), (R)-enantiomer, (S)-enantiomer, Cytochrome P450-mediated metabolism, Pgp function, liquid chromatography tandem mass spectrometry (LC/MS/MS), Chinese hamster ovary resistant cells (CHrB30), [99mTc]sestamibi, Single nucleotide polymorphism (SNP), [11C]phenobarbital, [11C]phenytoin" @default.
• W2088998237 created "2016-06-24" @default.
• W2088998237 creator A5004953156 @default.
• W2088998237 creator A5010235451 @default.
• W2088998237 date "2010-12-01" @default.
• W2088998237 modified "2023-09-25" @default.
• W2088998237 title "Imaging of P-glycoprotein Function and Expression to Elucidate Mechanisms of Pharmacoresistance in Epilepsy" @default.
• W2088998237 cites W1540089293 @default.
• W2088998237 cites W1758163856 @default.
• W2088998237 cites W1807250678 @default.
• W2088998237 cites W1915934302 @default.
• W2088998237 cites W1967913742 @default.
• W2088998237 cites W1968066079 @default.
• W2088998237 cites W1968482535 @default.
• W2088998237 cites W1968980689 @default.
• W2088998237 cites W1971129489 @default.
• W2088998237 cites W1971607633 @default.
• W2088998237 cites W1975209977 @default.
• W2088998237 cites W1977595701 @default.
• W2088998237 cites W1978672997 @default.
• W2088998237 cites W1980394909 @default.
• W2088998237 cites W1993337516 @default.
• W2088998237 cites W2004296825 @default.
• W2088998237 cites W2010081009 @default.
• W2088998237 cites W2020651374 @default.
• W2088998237 cites W2021118916 @default.
• W2088998237 cites W2024250662 @default.
• W2088998237 cites W2028441136 @default.
• W2088998237 cites W2030655611 @default.
• W2088998237 cites W2031483215 @default.
• W2088998237 cites W2034715941 @default.
• W2088998237 cites W2038090084 @default.
• W2088998237 cites W2048238274 @default.
• W2088998237 cites W2052329451 @default.
• W2088998237 cites W2055493796 @default.
• W2088998237 cites W2061326717 @default.
• W2088998237 cites W2061928059 @default.
• W2088998237 cites W2071363367 @default.
• W2088998237 cites W2072223301 @default.
• W2088998237 cites W2072981607 @default.
• W2088998237 cites W2073313174 @default.
• W2088998237 cites W2082471261 @default.
• W2088998237 cites W2083673453 @default.
• W2088998237 cites W2090291844 @default.
• W2088998237 cites W2092404798 @default.
• W2088998237 cites W2096045848 @default.
• W2088998237 cites W2111547513 @default.
• W2088998237 cites W2116749841 @default.
• W2088998237 cites W2119085762 @default.
• W2088998237 cites W2121878832 @default.
• W2088998237 cites W2129122317 @default.
• W2088998237 cites W2138935969 @default.
• W2088998237 cites W2140293712 @default.
• W2088998237 cites W2149016411 @default.
• W2088998237 cites W2151018358 @default.
• W2088998237 cites W2152546397 @default.
• W2088998237 cites W2153474045 @default.
• W2088998237 cites W2155720667 @default.
• W2088998237 cites W2158134221 @default.
• W2088998237 cites W2163967054 @default.
• W2088998237 cites W2166637794 @default.
• W2088998237 cites W2169006271 @default.
• W2088998237 cites W2171664964 @default.
• W2088998237 cites W2123002505 @default.
• W2088998237 doi "https://doi.org/10.2174/156802610792928095" @default.
• W2088998237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3689923" @default.
• W2088998237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20645916" @default.
• W2088998237 hasPublicationYear "2010" @default.
• W2088998237 type Work @default.
• W2088998237 sameAs 2088998237 @default.
• W2088998237 citedByCount "40" @default.
• W2088998237 countsByYear W20889982372012 @default.
• W2088998237 countsByYear W20889982372013 @default.
• W2088998237 countsByYear W20889982372014 @default.
• W2088998237 countsByYear W20889982372015 @default.
• W2088998237 countsByYear W20889982372016 @default.
• W2088998237 countsByYear W20889982372017 @default.
• W2088998237 countsByYear W20889982372019 @default.
• W2088998237 countsByYear W20889982372020 @default.
• W2088998237 countsByYear W20889982372021 @default.
• W2088998237 countsByYear W20889982372022 @default.
• W2088998237 countsByYear W20889982372023 @default.
• W2088998237 crossrefType "journal-article" @default.
• W2088998237 hasAuthorship W2088998237A5004953156 @default.
• W2088998237 hasAuthorship W2088998237A5010235451 @default.
• W2088998237 hasBestOaLocation W20889982372 @default.
• W2088998237 hasConcept C104317684 @default.
• W2088998237 hasConcept C118552586 @default.
• W2088998237 hasConcept C133936738 @default.
• W2088998237 hasConcept C149011108 @default.
• W2088998237 hasConcept C185592680 @default.
• W2088998237 hasConcept C2778186239 @default.
• W2088998237 hasConcept C2778707650 @default.
• W2088998237 hasConcept C501593827 @default.
• W2088998237 hasConcept C55493867 @default.
• W2088998237 hasConcept C71924100 @default.
• W2088998237 hasConcept C98274493 @default.
• W2088998237 hasConceptScore W2088998237C104317684 @default.

• next