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• W2089013784 startingPage "307" @default.
• W2089013784 abstract "ABSTRACT: The mechanical characteristics of the human lung have been well studied in relation to aging, under conditions of rest, exercise and various stresses, including the effect of drugs. The few studies that have been made on the control of ventilation with aging have not revealed any loss of response of the “respiratory centers” in normal elderly people. The ventilatory response to inhalation of high concentrations of CO2 is depressed under conditions believed to act centrally on the “respiratory centers,” e.g., during sleep. Normal aging may be associated with loss of CNS cells as well as sleep disturbances, but there is no proof that it is associated with abnormalities of ventilatory response. The ventilatory response to CO2 inhalation is influenced also by peripheral factors; even normal persons respond inadequately if the work of breathing is increased by introducing resistance into the respiratory circuit. This matter requires further study in the aged. The clinical impression is yet to be established that Cheyne-Stokes breathing and snoring are more common in elderly normal subjects. In the person who snores, the sensitivity of the “respiratory centers” is reduced by sleep and the work of breathing is increased by upper-airway obstruction; a study of blood gases might indicate insensitivity of the respiratory center to CO2. To date there is no firm evidence that normal old age under ordinary conditions of living is associated with impaired regulation of respiration." @default.
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• W2089013784 date "1974-07-01" @default.
• W2089013784 modified "2023-10-18" @default.
• W2089013784 title "Sleep, Periodic Breathing and Snoring in the Aged: Control of Ventilation in the Aging and Diseased Respiratory System*" @default.
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• W2089013784 doi "https://doi.org/10.1111/j.1532-5415.1974.tb05399.x" @default.
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