FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089014731> ?p ?o ?g. }

• W2089014731 endingPage "117" @default.
• W2089014731 startingPage "111" @default.
• W2089014731 abstract "The 24-h urine of 75 C57 BL/6J mice injected s.c. with 0.5 mg/kg arsenic as sodium arsenite were examined for creatinine, S-adenosylmethionine (SAM), urea and inorganic arsenic metabolites including inorganic arsenic (ASi), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). There was interindividual variability of about a 10-fold range in the 24-h urinary excretion of creatinine (80-642 micrograms/24 h, variability (cv) of 33%), SAM (7.5-67.2 micrograms/24 h, cv of 38%), urea (9.5-89.7 mg/24 h, cv of 36%), ASi (0.1-1.6 microgram/24 h, cv of 48%), MMA (0.17-2.1 micrograms/24 h, cv of 50%), DMA (0.73-8.13 micrograms/24 h, cv of 32%) and total arsenic metabolites (1.0-10.4 micrograms/24 h, cv of 31%). Interindividual differences, varying by as much as 5-7-fold, were also found in the urinary proportion of ASi (3-23%, cv of 41%) and MMA (5-22%, cv of 37%), but not in the urinary proportion of DMA (64-90%, cv of 7%). The 24-h urinary excretion of all arsenic metabolites correlated with the 24-h urinary excretion of urea (r = 0.81), creatinine (r = 0.88) and SAM (r = 0.83) as did the 24-h urinary excretion of urea with creatinine (r = 0.94) and SAM (r = 0.86), and the 24-h urinary excretion of creatinine with SAM (r = 0.94). Taken together, these results suggest that the overall intracellular glutathione (GSH)-dependent redox state, as reflected by the 24-h urinary excretion of SAM and creatinine, is involved in the interindividual variability in total arsenic metabolite excretion by C57 BL/6J mice. These preliminary results were also discussed with regard to the involvement of intracellular GSH-dependent redox state in the regulation of the reduction and of the methylation steps of arsenic, and to interindividual variability in the urinary excretion of total arsenic metabolites as a possible complicating factor in the biological monitoring of occupational exposure to arsenic." @default.
• W2089014731 created "2016-06-24" @default.
• W2089014731 creator A5004379876 @default.
• W2089014731 creator A5034333188 @default.
• W2089014731 creator A5052434242 @default.
• W2089014731 creator A5052974916 @default.
• W2089014731 creator A5067747989 @default.
• W2089014731 creator A5089781298 @default.
• W2089014731 date "1995-07-01" @default.
• W2089014731 modified "2023-09-25" @default.
• W2089014731 title "Interindividual variability in the urinary excretion of inorganic arsenic metabolites by C57 BL/6J mice: possible involvement of a thiol/disulfide exchange mechanism" @default.
• W2089014731 cites W1559258409 @default.
• W2089014731 cites W1964478998 @default.
• W2089014731 cites W1967850583 @default.
• W2089014731 cites W1980042350 @default.
• W2089014731 cites W1988852471 @default.
• W2089014731 cites W2008051930 @default.
• W2089014731 cites W2015267490 @default.
• W2089014731 cites W2016478443 @default.
• W2089014731 cites W2018539752 @default.
• W2089014731 cites W2020026267 @default.
• W2089014731 cites W2022361181 @default.
• W2089014731 cites W2041782302 @default.
• W2089014731 cites W2046269325 @default.
• W2089014731 cites W2055562179 @default.
• W2089014731 cites W2056813646 @default.
• W2089014731 cites W2066485368 @default.
• W2089014731 cites W2068753862 @default.
• W2089014731 cites W2074528027 @default.
• W2089014731 cites W2085935155 @default.
• W2089014731 cites W2181148302 @default.
• W2089014731 cites W248833920 @default.
• W2089014731 doi "https://doi.org/10.1016/0378-4274(94)03240-8" @default.
• W2089014731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7542406" @default.
• W2089014731 hasPublicationYear "1995" @default.
• W2089014731 type Work @default.
• W2089014731 sameAs 2089014731 @default.
• W2089014731 citedByCount "9" @default.
• W2089014731 crossrefType "journal-article" @default.
• W2089014731 hasAuthorship W2089014731A5004379876 @default.
• W2089014731 hasAuthorship W2089014731A5034333188 @default.
• W2089014731 hasAuthorship W2089014731A5052434242 @default.
• W2089014731 hasAuthorship W2089014731A5052974916 @default.
• W2089014731 hasAuthorship W2089014731A5067747989 @default.
• W2089014731 hasAuthorship W2089014731A5089781298 @default.
• W2089014731 hasConcept C10146269 @default.
• W2089014731 hasConcept C126322002 @default.
• W2089014731 hasConcept C134018914 @default.
• W2089014731 hasConcept C178790620 @default.
• W2089014731 hasConcept C185592680 @default.
• W2089014731 hasConcept C2780026642 @default.
• W2089014731 hasConcept C2780306776 @default.
• W2089014731 hasConcept C2780365088 @default.
• W2089014731 hasConcept C502230775 @default.
• W2089014731 hasConcept C55493867 @default.
• W2089014731 hasConcept C71924100 @default.
• W2089014731 hasConcept C77411442 @default.
• W2089014731 hasConceptScore W2089014731C10146269 @default.
• W2089014731 hasConceptScore W2089014731C126322002 @default.
• W2089014731 hasConceptScore W2089014731C134018914 @default.
• W2089014731 hasConceptScore W2089014731C178790620 @default.
• W2089014731 hasConceptScore W2089014731C185592680 @default.
• W2089014731 hasConceptScore W2089014731C2780026642 @default.
• W2089014731 hasConceptScore W2089014731C2780306776 @default.
• W2089014731 hasConceptScore W2089014731C2780365088 @default.
• W2089014731 hasConceptScore W2089014731C502230775 @default.
• W2089014731 hasConceptScore W2089014731C55493867 @default.
• W2089014731 hasConceptScore W2089014731C71924100 @default.
• W2089014731 hasConceptScore W2089014731C77411442 @default.
• W2089014731 hasIssue "2" @default.
• W2089014731 hasLocation W20890147311 @default.
• W2089014731 hasLocation W20890147312 @default.
• W2089014731 hasOpenAccess W2089014731 @default.
• W2089014731 hasPrimaryLocation W20890147311 @default.
• W2089014731 hasRelatedWork W2011221150 @default.
• W2089014731 hasRelatedWork W2021846613 @default.
• W2089014731 hasRelatedWork W2042480476 @default.
• W2089014731 hasRelatedWork W2059373368 @default.
• W2089014731 hasRelatedWork W2074872267 @default.
• W2089014731 hasRelatedWork W2093166709 @default.
• W2089014731 hasRelatedWork W2095358360 @default.
• W2089014731 hasRelatedWork W2104218156 @default.
• W2089014731 hasRelatedWork W2409793232 @default.
• W2089014731 hasRelatedWork W2464693428 @default.
• W2089014731 hasVolume "78" @default.
• W2089014731 isParatext "false" @default.
• W2089014731 isRetracted "false" @default.
• W2089014731 magId "2089014731" @default.
• W2089014731 workType "article" @default.