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- W2089015496 abstract "Abstract Mutagenesis in Drosophila is complicated by the occurrence of mosaicism. This is minimal in radiation mutagenesis but predominant in chemical and spontaneous mutagenesis. Techniques for detecting mutations suffer from two limitations. In specific visible tests, “cryptic” mosaics which are phenotypically non-mutant may carry the altered gene in the gonad and hence require an additional generation for their detection. In sex-linked lethal tests only mutations affecting all gametes in a gonad are usually scored and detected. For chemical mutagens, the mosaic origin of many or most mutations may be observed by testing non-mutant lines for an additional generation. A theory resolving the differences between the two techniques is proposed. It permits the prediction of the F 2 : F 3 sex-linked lethal ratio from a specific visible test; it provides a method for calculating the maximum number of detectable mutational events induced by a mutagen in post-meiotic gametes; and under certain conditions it predicts that the ratio of sex-linked lethals to specific visible mutations, rather than varying with different mutagens, will be constant. The theory, if experimentally verified, will permit direct comparisons of mutagenesis in microbial systems with those in Drosophila . It will also provide guide lines for a similar quantification of the developmental complexities which obscure mutation studies in man." @default.
- W2089015496 created "2016-06-24" @default.
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- W2089015496 date "1964-05-01" @default.
- W2089015496 modified "2023-09-23" @default.
- W2089015496 title "A method for calculating the maximum number of mutational events in Drosophila melanogaster" @default.
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- W2089015496 doi "https://doi.org/10.1016/0022-5193(64)90057-8" @default.
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