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- W2089079245 abstract "Long-term administration of antipsychotic drugs can induce differential expression of a variety of genes in the brain, which may underscore the molecular mechanism of the clinical efficacy and/or side effects of antipsychotic drugs. We used cDNA microarray analysis to screen differentially expressed genes in rat frontal cortex under 4 weeks’ treatment of risperidone (1 mg/kg). Using real-time quantitative PCR, we were able to verify eight genes, whose expression were significantly upregulated in rat frontal cortex under chronic risperidone treatment when compared with control animals. These genes include receptor for activated protein kinase C, amida, cathepsin D, calpain 2, calcium-independent receptor for α-latrotoxin, monoamine oxidase B, polyubiquitin, and kinesin light chain. In view of the physiological function of these genes, the results of our study suggest that chronic risperidone treatment may affect the neurotransmission, synaptic plasticity, and proteolysis of brain cells. This study also demonstrates that cDNA mciroarray analysis is useful for uncovering genes that are regulated by chronic antipsychotic drugs treatment, which may help bring new insight into the molecular mechanism of antipsychotic drugs." @default.
- W2089079245 created "2016-06-24" @default.
- W2089079245 creator A5066812595 @default.
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- W2089079245 date "2004-11-10" @default.
- W2089079245 modified "2023-10-10" @default.
- W2089079245 title "Microarray Analysis of Differentially Expressed Genes in Rat Frontal Cortex Under Chronic Risperidone Treatment" @default.
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- W2089079245 doi "https://doi.org/10.1038/sj.npp.1300612" @default.
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