Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089091189> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2089091189 abstract "The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility that the graft-derived 5-HT hyperinnervation is governed by target-related effects present in the host neostriatum and the question of whether grafts rich in 5-HT cells can ameliorate the drug-induced motor asymmetry resulting from unilateral 6-OHDA lesions. Rats were allocated to one of two groups: lesion plus mesencephalic raphe grafts (group R5-HT/L); and lesion plus medullary raphe grafts (group C5-HT/L). A third group, sham-lesion plus mesencephalic raphe grafts (group R5-HT/S) was included. Complete recovery of (+)-amphetamine-induced rotation was observed only in rats which received 5-HT grafts derived from medullary raphe neurons. There was no marked recovery of apomorphine-induced rotation in either of the R5-HT/L and C5-HT/L groups. Immunohistochemistry showed that the R5-HT/L and C5-HT/L groups had 5-HT hyperinnervation in the neostriatum of the lesioned side. There was no target-related effect of the 6-OHDA-lesioned neostriatum specific for the different types of 5-HT tissue. It seems likely that the 5-HT tissue derived from the medullary raphe may contain additional neurotransmitters which contribute to the behavioral recovery." @default.
- W2089091189 created "2016-06-24" @default.
- W2089091189 creator A5011957356 @default.
- W2089091189 creator A5030909442 @default.
- W2089091189 creator A5036018066 @default.
- W2089091189 creator A5080545647 @default.
- W2089091189 creator A5085437482 @default.
- W2089091189 date "1992-10-01" @default.
- W2089091189 modified "2023-09-26" @default.
- W2089091189 title "Transplantation of embryonic mesencephalic and medullary raphe neurons to the neostriatum of rats with unilateral 6-hydroxydopamine lesions" @default.
- W2089091189 cites W1498891976 @default.
- W2089091189 cites W2005918772 @default.
- W2089091189 cites W2016441494 @default.
- W2089091189 cites W2032644802 @default.
- W2089091189 cites W2038197168 @default.
- W2089091189 cites W2054216686 @default.
- W2089091189 cites W2059198442 @default.
- W2089091189 cites W2060913507 @default.
- W2089091189 cites W2061749100 @default.
- W2089091189 cites W2062118159 @default.
- W2089091189 cites W2069170243 @default.
- W2089091189 cites W2138003083 @default.
- W2089091189 cites W2978672951 @default.
- W2089091189 doi "https://doi.org/10.1016/0006-8993(92)91667-4" @default.
- W2089091189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1360310" @default.
- W2089091189 hasPublicationYear "1992" @default.
- W2089091189 type Work @default.
- W2089091189 sameAs 2089091189 @default.
- W2089091189 citedByCount "2" @default.
- W2089091189 crossrefType "journal-article" @default.
- W2089091189 hasAuthorship W2089091189A5011957356 @default.
- W2089091189 hasAuthorship W2089091189A5030909442 @default.
- W2089091189 hasAuthorship W2089091189A5036018066 @default.
- W2089091189 hasAuthorship W2089091189A5080545647 @default.
- W2089091189 hasAuthorship W2089091189A5085437482 @default.
- W2089091189 hasConcept C105702510 @default.
- W2089091189 hasConcept C126322002 @default.
- W2089091189 hasConcept C134018914 @default.
- W2089091189 hasConcept C137183658 @default.
- W2089091189 hasConcept C142724271 @default.
- W2089091189 hasConcept C170493617 @default.
- W2089091189 hasConcept C195121873 @default.
- W2089091189 hasConcept C2775864247 @default.
- W2089091189 hasConcept C2777288102 @default.
- W2089091189 hasConcept C2777525119 @default.
- W2089091189 hasConcept C2777615928 @default.
- W2089091189 hasConcept C2778110749 @default.
- W2089091189 hasConcept C2780938664 @default.
- W2089091189 hasConcept C2781156865 @default.
- W2089091189 hasConcept C2911016594 @default.
- W2089091189 hasConcept C2911091166 @default.
- W2089091189 hasConcept C37000724 @default.
- W2089091189 hasConcept C513476851 @default.
- W2089091189 hasConcept C529278444 @default.
- W2089091189 hasConcept C71924100 @default.
- W2089091189 hasConcept C86803240 @default.
- W2089091189 hasConceptScore W2089091189C105702510 @default.
- W2089091189 hasConceptScore W2089091189C126322002 @default.
- W2089091189 hasConceptScore W2089091189C134018914 @default.
- W2089091189 hasConceptScore W2089091189C137183658 @default.
- W2089091189 hasConceptScore W2089091189C142724271 @default.
- W2089091189 hasConceptScore W2089091189C170493617 @default.
- W2089091189 hasConceptScore W2089091189C195121873 @default.
- W2089091189 hasConceptScore W2089091189C2775864247 @default.
- W2089091189 hasConceptScore W2089091189C2777288102 @default.
- W2089091189 hasConceptScore W2089091189C2777525119 @default.
- W2089091189 hasConceptScore W2089091189C2777615928 @default.
- W2089091189 hasConceptScore W2089091189C2778110749 @default.
- W2089091189 hasConceptScore W2089091189C2780938664 @default.
- W2089091189 hasConceptScore W2089091189C2781156865 @default.
- W2089091189 hasConceptScore W2089091189C2911016594 @default.
- W2089091189 hasConceptScore W2089091189C2911091166 @default.
- W2089091189 hasConceptScore W2089091189C37000724 @default.
- W2089091189 hasConceptScore W2089091189C513476851 @default.
- W2089091189 hasConceptScore W2089091189C529278444 @default.
- W2089091189 hasConceptScore W2089091189C71924100 @default.
- W2089091189 hasConceptScore W2089091189C86803240 @default.
- W2089091189 hasLocation W20890911891 @default.
- W2089091189 hasLocation W20890911892 @default.
- W2089091189 hasOpenAccess W2089091189 @default.
- W2089091189 hasPrimaryLocation W20890911891 @default.
- W2089091189 hasRelatedWork W1979875568 @default.
- W2089091189 hasRelatedWork W1980419611 @default.
- W2089091189 hasRelatedWork W1982956803 @default.
- W2089091189 hasRelatedWork W2044403386 @default.
- W2089091189 hasRelatedWork W2053299728 @default.
- W2089091189 hasRelatedWork W2055086186 @default.
- W2089091189 hasRelatedWork W2072166141 @default.
- W2089091189 hasRelatedWork W2085315144 @default.
- W2089091189 hasRelatedWork W2089091189 @default.
- W2089091189 hasRelatedWork W2107926609 @default.
- W2089091189 isParatext "false" @default.
- W2089091189 isRetracted "false" @default.
- W2089091189 magId "2089091189" @default.
- W2089091189 workType "article" @default.