FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089093959> ?p ?o ?g. }

• W2089093959 endingPage "E952" @default.
• W2089093959 startingPage "E948" @default.
• W2089093959 abstract "Context: Patients with TSH-secreting pituitary adenomas (TSHoma) show inappropriate secretion of TSH; serum TSH levels are not suppressed despite high serum free thyroid hormone levels. The mechanism of a defect in negative regulation of TSH in a TSHoma is still unclear. Objective: Recently, we cloned a novel thyroid hormone receptor β isoform (TRβ4) from a human pituitary library. To elucidate the clinical significance of TRβ4, we investigated the expression of this isoform in TSHoma. Methods: RT-PCR was performed to detect TRβ isoforms such as TRβ1, TRβ2, and TRβ4 using RNA obtained from surgically resected TSHoma. The effects of TRβ4 on the TSH gene expression were examined in the transient gene expression experiments. Results: Quantitative analysis using a real-time PCR revealed that relative expression of TRβ4 to TRβ1+2 was higher in three TSHoma than in a prolactinoma or a nonfunctioning pituitary adenoma. TRβ4 construct did not mediate T3-dependent gene regulation but inhibited the negative regulation of TSHα mediated by TRβ1 or TRβ2. Conclusions: Aberrant expression of TRβ4 may partly contribute to the inappropriate secretion of TSH in a TSHoma." @default.
• W2089093959 created "2016-06-24" @default.
• W2089093959 creator A5017805389 @default.
• W2089093959 creator A5032612272 @default.
• W2089093959 creator A5039919959 @default.
• W2089093959 creator A5047200294 @default.
• W2089093959 creator A5049772836 @default.
• W2089093959 creator A5073592675 @default.
• W2089093959 creator A5090348913 @default.
• W2089093959 date "2011-06-01" @default.
• W2089093959 modified "2023-10-16" @default.
• W2089093959 title "Aberrant Expression of Thyroid Hormone Receptor β Isoform May Cause Inappropriate Secretion of TSH in a TSH-Secreting Pituitary Adenoma" @default.
• W2089093959 cites W1978970191 @default.
• W2089093959 cites W2005890483 @default.
• W2089093959 cites W2011740100 @default.
• W2089093959 cites W2021507484 @default.
• W2089093959 cites W2021932599 @default.
• W2089093959 cites W2034071735 @default.
• W2089093959 cites W2080884925 @default.
• W2089093959 cites W2104971612 @default.
• W2089093959 cites W2145221641 @default.
• W2089093959 cites W2156575042 @default.
• W2089093959 cites W2160240007 @default.
• W2089093959 cites W2171308264 @default.
• W2089093959 doi "https://doi.org/10.1210/jc.2010-2496" @default.
• W2089093959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21430027" @default.
• W2089093959 hasPublicationYear "2011" @default.
• W2089093959 type Work @default.
• W2089093959 sameAs 2089093959 @default.
• W2089093959 citedByCount "31" @default.
• W2089093959 countsByYear W20890939592012 @default.
• W2089093959 countsByYear W20890939592013 @default.
• W2089093959 countsByYear W20890939592014 @default.
• W2089093959 countsByYear W20890939592015 @default.
• W2089093959 countsByYear W20890939592016 @default.
• W2089093959 countsByYear W20890939592017 @default.
• W2089093959 countsByYear W20890939592018 @default.
• W2089093959 countsByYear W20890939592019 @default.
• W2089093959 countsByYear W20890939592020 @default.
• W2089093959 countsByYear W20890939592021 @default.
• W2089093959 countsByYear W20890939592022 @default.
• W2089093959 countsByYear W20890939592023 @default.
• W2089093959 crossrefType "journal-article" @default.
• W2089093959 hasAuthorship W2089093959A5017805389 @default.
• W2089093959 hasAuthorship W2089093959A5032612272 @default.
• W2089093959 hasAuthorship W2089093959A5039919959 @default.
• W2089093959 hasAuthorship W2089093959A5047200294 @default.
• W2089093959 hasAuthorship W2089093959A5049772836 @default.
• W2089093959 hasAuthorship W2089093959A5073592675 @default.
• W2089093959 hasAuthorship W2089093959A5090348913 @default.
• W2089093959 hasBestOaLocation W20890939591 @default.
• W2089093959 hasConcept C104317684 @default.
• W2089093959 hasConcept C109115496 @default.
• W2089093959 hasConcept C126322002 @default.
• W2089093959 hasConcept C134018914 @default.
• W2089093959 hasConcept C150194340 @default.
• W2089093959 hasConcept C151730666 @default.
• W2089093959 hasConcept C170493617 @default.
• W2089093959 hasConcept C2777428134 @default.
• W2089093959 hasConcept C2778918492 @default.
• W2089093959 hasConcept C2779064019 @default.
• W2089093959 hasConcept C2779318953 @default.
• W2089093959 hasConcept C2779343474 @default.
• W2089093959 hasConcept C526584372 @default.
• W2089093959 hasConcept C53345823 @default.
• W2089093959 hasConcept C55493867 @default.
• W2089093959 hasConcept C71315377 @default.
• W2089093959 hasConcept C71924100 @default.
• W2089093959 hasConcept C86803240 @default.
• W2089093959 hasConceptScore W2089093959C104317684 @default.
• W2089093959 hasConceptScore W2089093959C109115496 @default.
• W2089093959 hasConceptScore W2089093959C126322002 @default.
• W2089093959 hasConceptScore W2089093959C134018914 @default.
• W2089093959 hasConceptScore W2089093959C150194340 @default.
• W2089093959 hasConceptScore W2089093959C151730666 @default.
• W2089093959 hasConceptScore W2089093959C170493617 @default.
• W2089093959 hasConceptScore W2089093959C2777428134 @default.
• W2089093959 hasConceptScore W2089093959C2778918492 @default.
• W2089093959 hasConceptScore W2089093959C2779064019 @default.
• W2089093959 hasConceptScore W2089093959C2779318953 @default.
• W2089093959 hasConceptScore W2089093959C2779343474 @default.
• W2089093959 hasConceptScore W2089093959C526584372 @default.
• W2089093959 hasConceptScore W2089093959C53345823 @default.
• W2089093959 hasConceptScore W2089093959C55493867 @default.
• W2089093959 hasConceptScore W2089093959C71315377 @default.
• W2089093959 hasConceptScore W2089093959C71924100 @default.
• W2089093959 hasConceptScore W2089093959C86803240 @default.
• W2089093959 hasIssue "6" @default.
• W2089093959 hasLocation W20890939591 @default.
• W2089093959 hasLocation W20890939592 @default.
• W2089093959 hasOpenAccess W2089093959 @default.
• W2089093959 hasPrimaryLocation W20890939591 @default.
• W2089093959 hasRelatedWork W1972051303 @default.
• W2089093959 hasRelatedWork W1985670913 @default.
• W2089093959 hasRelatedWork W2010645160 @default.
• W2089093959 hasRelatedWork W2073158788 @default.
• W2089093959 hasRelatedWork W2096799980 @default.
• W2089093959 hasRelatedWork W2127836255 @default.

• next