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• W2089094573 abstract "Amyotrophic lateral sclerosis (ALS) is an adult-onset and heterogeneous neurological disorder that affects primarily motor neurons in the brain and spinal cord. Although multiple genetic and environmental factors might be implicated in ALS, the striking similarities in the clinical and pathological features of sporadic ALS and familial ALS suggest that similar mechanisms of disease may occur. A common and perhaps universal pathological finding in ALS is the presence of abnormal accumulations of neurofilaments (often called spheroids or Lewy body-like deposits) in the cell body and proximal axon of surviving motor neurons. Such neurofilament deposits have been widely viewed as a consequence of neuronal dysfunction, perhaps reflecting axonal transport defects. This review discusses the emerging evidence, based primarily on transgenic mouse studies and on the discovery of deletion mutations in a neurofilament gene associated with ALS, that neurofilament proteins can play a causative role in motor neuron disease." @default.
• W2089094573 created "2016-06-24" @default.
• W2089094573 creator A5091664460 @default.
• W2089094573 date "1997-06-01" @default.
• W2089094573 modified "2023-09-23" @default.
• W2089094573 title "Neurofilaments and motor neuron disease" @default.
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• W2089094573 doi "https://doi.org/10.1016/s0962-8924(97)01049-0" @default.
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