FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089096931> ?p ?o ?g. }

• W2089096931 endingPage "669" @default.
• W2089096931 startingPage "663" @default.
• W2089096931 abstract "Nasal polyps are associated with chronic inflammation of the sinonasal mucosa and are involved in myofibroblast differentiation and extracellular matrix (ECM) accumulation. Ginsenoside Rg1, a compound derived from Panax ginseng, shows antifibrotic and anticancer effects. However, the molecular effects of Rg1 on myofibroblast differentiation and ECM production remain unknown. The aims of this study were to investigate the effect of Rg1 on transforming growth factor (TGF)- β1-induced myofibroblast differentiation and ECM production and to determine the molecular mechanism of Rg1 in nasal polyp-derived fibroblasts (NPDFs). NPDFs were isolated from nasal polyps of seven patients who had chronic rhinosinusitis with nasal polyp. NPDFs were exposed to TGF- β1 with or without Rg1. Expression levels of α-smooth muscle actin (SMA), fibronectin and collagen type I α1 were determined by reverse transcription polymerase chain reaction, Western blot and immunofluorescent staining. TGF- β1 signaling molecules, including Smad2/3, extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 were analyzed by Western blotting. Transcription factors involved with TGF- β1 signaling, nuclear factor (NF)- κB and activator protein 1 (AP-1) were also assessed by Western blot. The cytotoxic effect of Rg1 was measured by an established viability assay. The mRNA and protein expression levels of α-SMA, fibronectin and collagen type I α1 were increased in TGF- β1-induced NPDFs. Rg1 inhibited these effects. The inhibitory molecular mechanism of Rg1 was involved in the ERK pathway. Rg1 inhibited the transcription factor activation of AP-1. Rg1 itself was not cytotoxic. The ginsenoside Rg1 has inhibitory effects on myofibroblast differentiation and ECM production. The inhibitory mechanism of Rg1 is involved with the ERK and AP-1 signaling pathways. Rg1 may be useful as an inhibitor of ECM deposition, and has potential to be used as a novel treatment option for nasal polyps." @default.
• W2089096931 created "2016-06-24" @default.
• W2089096931 creator A5012945733 @default.
• W2089096931 creator A5044625040 @default.
• W2089096931 creator A5047689997 @default.
• W2089096931 creator A5056355893 @default.
• W2089096931 creator A5076458741 @default.
• W2089096931 creator A5086363454 @default.
• W2089096931 date "2012-06-01" @default.
• W2089096931 modified "2023-09-23" @default.
• W2089096931 title "Inhibitory effect of ginsenoside Rg1 on extracellular matrix production via extracellular signal-regulated protein kinase/activator protein 1 pathway in nasal polyp-derived fibroblasts" @default.
• W2089096931 cites W153955614 @default.
• W2089096931 cites W1852199403 @default.
• W2089096931 cites W1967981485 @default.
• W2089096931 cites W1978593002 @default.
• W2089096931 cites W1983409792 @default.
• W2089096931 cites W1998325814 @default.
• W2089096931 cites W2027860197 @default.
• W2089096931 cites W2036881655 @default.
• W2089096931 cites W2044332760 @default.
• W2089096931 cites W2047083679 @default.
• W2089096931 cites W2055082498 @default.
• W2089096931 cites W2064699135 @default.
• W2089096931 cites W2080334303 @default.
• W2089096931 cites W2081403531 @default.
• W2089096931 cites W2083531592 @default.
• W2089096931 cites W2092240515 @default.
• W2089096931 cites W2096224929 @default.
• W2089096931 cites W2101325041 @default.
• W2089096931 cites W2103868295 @default.
• W2089096931 cites W2118541435 @default.
• W2089096931 cites W2154036623 @default.
• W2089096931 cites W2155612395 @default.
• W2089096931 doi "https://doi.org/10.1258/ebm.2012.011342" @default.
• W2089096931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728707" @default.
• W2089096931 hasPublicationYear "2012" @default.
• W2089096931 type Work @default.
• W2089096931 sameAs 2089096931 @default.
• W2089096931 citedByCount "13" @default.
• W2089096931 countsByYear W20890969312014 @default.
• W2089096931 countsByYear W20890969312015 @default.
• W2089096931 countsByYear W20890969312016 @default.
• W2089096931 countsByYear W20890969312017 @default.
• W2089096931 countsByYear W20890969312019 @default.
• W2089096931 countsByYear W20890969312020 @default.
• W2089096931 countsByYear W20890969312021 @default.
• W2089096931 countsByYear W20890969312022 @default.
• W2089096931 crossrefType "journal-article" @default.
• W2089096931 hasAuthorship W2089096931A5012945733 @default.
• W2089096931 hasAuthorship W2089096931A5044625040 @default.
• W2089096931 hasAuthorship W2089096931A5047689997 @default.
• W2089096931 hasAuthorship W2089096931A5056355893 @default.
• W2089096931 hasAuthorship W2089096931A5076458741 @default.
• W2089096931 hasAuthorship W2089096931A5086363454 @default.
• W2089096931 hasConcept C104317684 @default.
• W2089096931 hasConcept C118131993 @default.
• W2089096931 hasConcept C142724271 @default.
• W2089096931 hasConcept C153911025 @default.
• W2089096931 hasConcept C170493617 @default.
• W2089096931 hasConcept C184235292 @default.
• W2089096931 hasConcept C185592680 @default.
• W2089096931 hasConcept C189165786 @default.
• W2089096931 hasConcept C203014093 @default.
• W2089096931 hasConcept C207865475 @default.
• W2089096931 hasConcept C2776415932 @default.
• W2089096931 hasConcept C2778229498 @default.
• W2089096931 hasConcept C2780559512 @default.
• W2089096931 hasConcept C2781390199 @default.
• W2089096931 hasConcept C51551487 @default.
• W2089096931 hasConcept C55493867 @default.
• W2089096931 hasConcept C57074206 @default.
• W2089096931 hasConcept C62478195 @default.
• W2089096931 hasConcept C71924100 @default.
• W2089096931 hasConcept C85265743 @default.
• W2089096931 hasConcept C86492073 @default.
• W2089096931 hasConcept C86803240 @default.
• W2089096931 hasConcept C88045685 @default.
• W2089096931 hasConcept C95444343 @default.
• W2089096931 hasConcept C97029542 @default.
• W2089096931 hasConceptScore W2089096931C104317684 @default.
• W2089096931 hasConceptScore W2089096931C118131993 @default.
• W2089096931 hasConceptScore W2089096931C142724271 @default.
• W2089096931 hasConceptScore W2089096931C153911025 @default.
• W2089096931 hasConceptScore W2089096931C170493617 @default.
• W2089096931 hasConceptScore W2089096931C184235292 @default.
• W2089096931 hasConceptScore W2089096931C185592680 @default.
• W2089096931 hasConceptScore W2089096931C189165786 @default.
• W2089096931 hasConceptScore W2089096931C203014093 @default.
• W2089096931 hasConceptScore W2089096931C207865475 @default.
• W2089096931 hasConceptScore W2089096931C2776415932 @default.
• W2089096931 hasConceptScore W2089096931C2778229498 @default.
• W2089096931 hasConceptScore W2089096931C2780559512 @default.
• W2089096931 hasConceptScore W2089096931C2781390199 @default.
• W2089096931 hasConceptScore W2089096931C51551487 @default.
• W2089096931 hasConceptScore W2089096931C55493867 @default.
• W2089096931 hasConceptScore W2089096931C57074206 @default.
• W2089096931 hasConceptScore W2089096931C62478195 @default.
• W2089096931 hasConceptScore W2089096931C71924100 @default.

• next