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- W2089101228 abstract "Induction of CD95 ligand (CD95-L) may contribute to drug-induced apoptosis in chemosensitive leukemias and solid tumors. Here we report that induction of CD95-L and apoptosis by doxorubicin in leukemic and neuroblastoma cells is regulated by the redox state and reactive oxygen species (ROS). Preincubation of chemosensitive cells with antioxidants such as N-acetyl-cysteine (NAC) or glutathione (GSH), significantly reduced doxorubicin-induced apoptosis, hyperexpression of ROS, loss of mitochondrial membrane potential (ΔΨm) and upregulation of CD95-L expression. Doxorubicin-resistant cells exhibited higher levels of GSH in comparison to chemosensitive cells and were deficient in hyperproduction of ROS, loss of ΔΨm and upregulation of CD95-L in response to cytotoxic drugs. Downregulation of intracellular GSH concentrations reversed deficient drug-induced hyperproduction of ROS and CD95-L upregulation. In addition, overexpression of Bcl-XL in CEM cells blocked doxorubicin-triggered ROS and CD95-L expression. These findings suggest that induction of CD95-L by cytotoxic drugs is modulated by the cellular redox state and mitochondria derived ROS." @default.
- W2089101228 created "2016-06-24" @default.
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- W2089101228 date "1999-05-01" @default.
- W2089101228 modified "2023-10-11" @default.
- W2089101228 title "Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells" @default.
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- W2089101228 cites W1530002036 @default.
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- W2089101228 cites W1598875012 @default.
- W2089101228 cites W1629770860 @default.
- W2089101228 cites W1632979324 @default.
- W2089101228 cites W1651860280 @default.
- W2089101228 cites W1669763518 @default.
- W2089101228 cites W1836073275 @default.
- W2089101228 cites W189540926 @default.
- W2089101228 cites W1950610522 @default.
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- W2089101228 cites W1973792489 @default.
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- W2089101228 cites W2002503549 @default.
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- W2089101228 doi "https://doi.org/10.1038/sj.cdd.4400512" @default.
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