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- W2089102577 endingPage "e111583" @default.
- W2089102577 startingPage "e111583" @default.
- W2089102577 abstract "Background Risky decision-making is commonly observed in persons at risk for and infected with HIV and is associated with executive dysfunction. Yet it is currently unknown whether HIV alters brain processing of risk-taking decision-making. Methods This study examined the neural substrate of a risky decision-making task in 21 HIV seropositive (HIV+) and 19 seronegative (HIV-) comparison participants. Functional magnetic resonance imaging was conducted while participants performed the risky-gains task, which involves choosing among safe (20 cents) and risky (40/80 cent win or loss) choices. Linear mixed effects analyses examining group and decision type were conducted. Robust regressions were performed to examine the relationship between nadir CD4 count and Kalichman sexual compulsivity and brain activation in the HIV+ group. The overlap between the task effects and robust regressions was explored. Results Although there were no serostatus effects in behavioral performance on the risky-gains task, HIV+ individuals exhibited greater activation for risky choices in the basal ganglia, i.e. the caudate nucleus, but also in the anterior cingulate, dorsolateral prefrontal cortex, and insula relative to the HIV- group. The HIV+ group also demonstrated reduced functional responses to safe choices in the anterior cingulate and dorsolateral prefrontal cortex relative to the HIV- group. HIV+ individuals with higher nadir CD4 count and greater sexual compulsivity displayed lower differential responses to safe versus risky choices in many of these regions. Conclusions This study demonstrated fronto-striatal loop dysfunction associated with HIV infection during risky decision-making. Combined with similar between-group task behavior, this suggests an adaptive functional response in regions critical to reward and behavioral control in the HIV+ group. HIV-infected individuals with higher CD4 nadirs demonstrated activation patterns more similar to seronegative individuals. This suggests that the severity of past immunosuppression (CD4 nadir) may exert a legacy effect on processing of risky choices in the HIV-infected brain." @default.
- W2089102577 created "2016-06-24" @default.
- W2089102577 creator A5008449643 @default.
- W2089102577 creator A5022546339 @default.
- W2089102577 creator A5025523388 @default.
- W2089102577 creator A5028558751 @default.
- W2089102577 creator A5045721970 @default.
- W2089102577 creator A5063654181 @default.
- W2089102577 creator A5081736253 @default.
- W2089102577 date "2014-10-27" @default.
- W2089102577 modified "2023-10-15" @default.
- W2089102577 title "Altered Functional Response to Risky Choice in HIV Infection" @default.
- W2089102577 cites W1513126258 @default.
- W2089102577 cites W1517620957 @default.
- W2089102577 cites W1594303435 @default.
- W2089102577 cites W1963537210 @default.
- W2089102577 cites W1964859800 @default.
- W2089102577 cites W1969913560 @default.
- W2089102577 cites W1972236051 @default.
- W2089102577 cites W1976434061 @default.
- W2089102577 cites W1978613454 @default.
- W2089102577 cites W1980554112 @default.
- W2089102577 cites W1981245491 @default.
- W2089102577 cites W1985399534 @default.
- W2089102577 cites W1985516139 @default.
- W2089102577 cites W1988706006 @default.
- W2089102577 cites W1988900980 @default.
- W2089102577 cites W1989609167 @default.
- W2089102577 cites W1990131415 @default.
- W2089102577 cites W1990783722 @default.
- W2089102577 cites W1992863772 @default.
- W2089102577 cites W1993852907 @default.
- W2089102577 cites W1995810302 @default.
- W2089102577 cites W1997682954 @default.
- W2089102577 cites W2000998192 @default.
- W2089102577 cites W2002198553 @default.
- W2089102577 cites W2003726800 @default.
- W2089102577 cites W2006096283 @default.
- W2089102577 cites W2007774400 @default.
- W2089102577 cites W2008258216 @default.
- W2089102577 cites W2008536345 @default.
- W2089102577 cites W2008709921 @default.
- W2089102577 cites W2013657375 @default.
- W2089102577 cites W2013870111 @default.
- W2089102577 cites W2013906807 @default.
- W2089102577 cites W2014114421 @default.
- W2089102577 cites W2014416087 @default.
- W2089102577 cites W2014552053 @default.
- W2089102577 cites W2016521818 @default.
- W2089102577 cites W2017646104 @default.
- W2089102577 cites W2018731294 @default.
- W2089102577 cites W2021309726 @default.
- W2089102577 cites W2022490111 @default.
- W2089102577 cites W2024217712 @default.
- W2089102577 cites W2025928167 @default.
- W2089102577 cites W2026586986 @default.
- W2089102577 cites W2030858058 @default.
- W2089102577 cites W2031170958 @default.
- W2089102577 cites W2034354169 @default.
- W2089102577 cites W2039102080 @default.
- W2089102577 cites W2041946752 @default.
- W2089102577 cites W2042659172 @default.
- W2089102577 cites W2046033161 @default.
- W2089102577 cites W2048224422 @default.
- W2089102577 cites W2049689895 @default.
- W2089102577 cites W2050240357 @default.
- W2089102577 cites W2050618347 @default.
- W2089102577 cites W2050718942 @default.
- W2089102577 cites W2052305221 @default.
- W2089102577 cites W2052329772 @default.
- W2089102577 cites W2052610531 @default.
- W2089102577 cites W2052644075 @default.
- W2089102577 cites W2054515032 @default.
- W2089102577 cites W2055740486 @default.
- W2089102577 cites W2056813461 @default.
- W2089102577 cites W2056908956 @default.
- W2089102577 cites W2057778345 @default.
- W2089102577 cites W2066816136 @default.
- W2089102577 cites W2067495470 @default.
- W2089102577 cites W2071189762 @default.
- W2089102577 cites W2072601872 @default.
- W2089102577 cites W2073813229 @default.
- W2089102577 cites W2076256116 @default.
- W2089102577 cites W2076324253 @default.
- W2089102577 cites W2077716619 @default.
- W2089102577 cites W2081357085 @default.
- W2089102577 cites W2083068159 @default.
- W2089102577 cites W2087615164 @default.
- W2089102577 cites W2088171224 @default.
- W2089102577 cites W2091069417 @default.
- W2089102577 cites W2093554933 @default.
- W2089102577 cites W2095882961 @default.
- W2089102577 cites W2098533877 @default.
- W2089102577 cites W2099652807 @default.
- W2089102577 cites W2100466611 @default.
- W2089102577 cites W2100879297 @default.
- W2089102577 cites W2102474944 @default.
- W2089102577 cites W2102493402 @default.