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- W2089107230 abstract "Abstract Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventional chemotherapy. The greatest benefit from ASCT is obtained in patients achieving CR after transplantation, the likelihood of CR being associated with the M-protein size at the time of transplantation. The incorporation of novel agents results in higher pre- and posttransplantation CR rates. Induction with bortezomib-containing regimens is encouraging in patients with poor-risk cytogenetics. However, longer follow-up is required to assess the impact of this increased CR on long-term survival. The results of posttransplantation consolidation/maintenance with new drugs are encouraging. All this indicates that, in the era of novel agents, high-dose therapy should be optimized rather than replaced. Because of its high transplantation-related mortality, myeloablative allografting has been generally replaced by reduced-intensity conditioning (reduced intensity conditioning allogeneic transplantation). The best results are achieved after a debulky ASCT, with a progression-free survival plateau of 25% to 30% beyond 6 years from reduced intensity conditioning allogeneic transplantation. The development of novel reduced-intensity preparative regimens and peri- and posttransplantation strategies aimed at minimizing graft-versus-host disease, and enhancing the graft-versus-myeloma effect are key issues." @default.
- W2089107230 created "2016-06-24" @default.
- W2089107230 creator A5015898454 @default.
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- W2089107230 creator A5031837957 @default.
- W2089107230 creator A5069533479 @default.
- W2089107230 creator A5076935487 @default.
- W2089107230 date "2010-05-06" @default.
- W2089107230 modified "2023-09-30" @default.
- W2089107230 title "Hematopoietic stem cell transplantation for multiple myeloma beyond 2010" @default.
- W2089107230 cites W121638319 @default.
- W2089107230 cites W1233091556 @default.
- W2089107230 cites W1914208484 @default.
- W2089107230 cites W195783192 @default.
- W2089107230 cites W1959587708 @default.
- W2089107230 cites W1967381972 @default.
- W2089107230 cites W1968578379 @default.
- W2089107230 cites W1970074537 @default.
- W2089107230 cites W1977390830 @default.
- W2089107230 cites W1990614933 @default.
- W2089107230 cites W1991268858 @default.
- W2089107230 cites W1992231323 @default.
- W2089107230 cites W1995669533 @default.
- W2089107230 cites W1995984173 @default.
- W2089107230 cites W2010766702 @default.
- W2089107230 cites W2011871138 @default.
- W2089107230 cites W2014946770 @default.
- W2089107230 cites W2017303578 @default.
- W2089107230 cites W2020778579 @default.
- W2089107230 cites W2024733207 @default.
- W2089107230 cites W2025828169 @default.
- W2089107230 cites W2030604738 @default.
- W2089107230 cites W2034236066 @default.
- W2089107230 cites W2048742751 @default.
- W2089107230 cites W2055284972 @default.
- W2089107230 cites W2057965689 @default.
- W2089107230 cites W2058987824 @default.
- W2089107230 cites W2059213807 @default.
- W2089107230 cites W2059733579 @default.
- W2089107230 cites W2060302368 @default.
- W2089107230 cites W2066295909 @default.
- W2089107230 cites W2066519436 @default.
- W2089107230 cites W2066800926 @default.
- W2089107230 cites W2067962862 @default.
- W2089107230 cites W2069679926 @default.
- W2089107230 cites W2071606914 @default.
- W2089107230 cites W2078115159 @default.
- W2089107230 cites W2080264915 @default.
- W2089107230 cites W2084542540 @default.
- W2089107230 cites W2086692682 @default.
- W2089107230 cites W2088540908 @default.
- W2089107230 cites W2090568070 @default.
- W2089107230 cites W2092000830 @default.
- W2089107230 cites W2093757149 @default.
- W2089107230 cites W2095124784 @default.
- W2089107230 cites W2096207943 @default.
- W2089107230 cites W2102591890 @default.
- W2089107230 cites W2104897208 @default.
- W2089107230 cites W2107057207 @default.
- W2089107230 cites W2113604545 @default.
- W2089107230 cites W2117543514 @default.
- W2089107230 cites W2121236166 @default.
- W2089107230 cites W2121399230 @default.
- W2089107230 cites W2122021478 @default.
- W2089107230 cites W2122277484 @default.
- W2089107230 cites W2124116840 @default.
- W2089107230 cites W2127143739 @default.
- W2089107230 cites W2127846055 @default.
- W2089107230 cites W2128880706 @default.
- W2089107230 cites W2131394075 @default.
- W2089107230 cites W2132392953 @default.
- W2089107230 cites W2133590829 @default.
- W2089107230 cites W2134592456 @default.
- W2089107230 cites W2135514413 @default.
- W2089107230 cites W2136256331 @default.
- W2089107230 cites W2136373453 @default.
- W2089107230 cites W2137061476 @default.
- W2089107230 cites W2141451077 @default.
- W2089107230 cites W2141505412 @default.
- W2089107230 cites W2145651125 @default.
- W2089107230 cites W2146607984 @default.
- W2089107230 cites W2146909892 @default.
- W2089107230 cites W2147082411 @default.
- W2089107230 cites W2148188974 @default.
- W2089107230 cites W2148672632 @default.
- W2089107230 cites W2148758597 @default.
- W2089107230 cites W2150254829 @default.
- W2089107230 cites W2152333590 @default.
- W2089107230 cites W2153472639 @default.
- W2089107230 cites W2153596485 @default.
- W2089107230 cites W2155988805 @default.
- W2089107230 cites W2161702482 @default.
- W2089107230 cites W2164146393 @default.
- W2089107230 cites W2228175078 @default.
- W2089107230 cites W2254100600 @default.
- W2089107230 cites W2321655863 @default.
- W2089107230 cites W2322962980 @default.
- W2089107230 cites W2325022302 @default.