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- W2089107879 abstract "SOD mimics with varying coligand are momentous in developing potential chemotherapeutic drugs. Cu(II) based SOD mimics 1–4 [CuLH(OAc)(H2O)Y)] (LH = 2-((E)-(1,3-dihydroxy-2-methylpropan-2-ylimino)methyl)-6-methoxyphenol, OAc = CH3COO, 1: Y = H2O; 2: Y = phen (1,10-phenanthroline), 3: Y = tpimH (2,4,5-triphenylimidazole); 4: Y = tfbimH (2-(trifluoromethyl)benzimidazole) were synthesized and thoroughly characterized. Their interaction with CT-DNA showed different non-covalent binding behaviour. SOD activity of 2 was highest among 1–4 which was further validated by gel electrophoresis. The pBR322 plasmid strand break offered by 2 + O2·− system reveals oxidative cleavage mechanism. In vitro antimicrobial activity of 1–4 was shown by percent inhibition data while in vitro anticancer activity of 1–4 was screened using 16 human carcinoma cell lines of different histological origin. Complex 2 showed higher efficacy towards 14 cell lines." @default.
- W2089107879 created "2016-06-24" @default.
- W2089107879 creator A5004678640 @default.
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- W2089107879 creator A5074424152 @default.
- W2089107879 creator A5074522065 @default.
- W2089107879 creator A5084938854 @default.
- W2089107879 date "2013-02-01" @default.
- W2089107879 modified "2023-10-14" @default.
- W2089107879 title "Mixed-ligand Cu(II)–vanillin Schiff base complexes; effect of coligands on their DNA binding, DNA cleavage, SOD mimetic and anticancer activity" @default.
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