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• W2089109522 endingPage "167" @default.
• W2089109522 startingPage "161" @default.
• W2089109522 abstract "The placenta comprises a highly specialized trophoblast layer, which arises from the embryo and differentiates during embryonic development to perform specialized functions, e.g., synthesis of pregnancy-associated hormones, growth factors and cytokines. As there is no evidence of maternal acute-phase protein transplacental transfer and trophoblast plays an important role in regulating immune responses at the feto-maternal interface, the expression of acute-phase serum amyloid A (A-SAA) was investigated in human first trimester trophoblast and trophoblast-like JAR and Jeg-3 choriocarcinoma cells. We here show expression of cytokine receptors and cytokine-dependent induction of A-SAA in JAR and Jeg-3 cells. While interleukin-1α/β is a major agonist for A-SAA expression in JAR, tumor necrosis factor-α is the predominant agonist in Jeg-3. First trimester trophoblast and JAR/Jeg-3 cells further express the human homolog of SAA-activating factor-1, a transcription factor involved in cytokine-mediated induction of A-SAA genes. A-SAA1 and A-SAA2 transcripts were increased in first trimester trophoblast during pregnancy weeks 10 and 12 suggesting that A-SAA plays a role during early fetal development." @default.
• W2089109522 created "2016-06-24" @default.
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• W2089109522 date "2005-12-06" @default.
• W2089109522 modified "2023-10-17" @default.
• W2089109522 title "Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells" @default.
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• W2089109522 doi "https://doi.org/10.1016/j.febslet.2005.11.067" @default.
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