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• W2089125503 abstract "Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which--in turn--becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules." @default.
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• W2089125503 date "2013-07-19" @default.
• W2089125503 modified "2023-10-14" @default.
• W2089125503 title "Bio-responsive polymer hydrogels homeostatically regulate blood coagulation" @default.
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• W2089125503 doi "https://doi.org/10.1038/ncomms3168" @default.
• W2089125503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3759053" @default.
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