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- W2089137138 abstract "Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine <TEX>${beta}$</TEX>-hydroxylase (DBH) inhibitor. <TEX>$IC_{50}$</TEX> values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 <TEX>${mu}M$</TEX>, and 43.9 <TEX>${mu}M$</TEX>. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The <TEX>$IC_{50}$</TEX> values of iproniazid were 37 <TEX>${mu}M$</TEX>, and 42.5 <TEX>${mu}M$</TEX> in our parallel examination. Moreover, <TEX>$IC_{50}$</TEX> value of xanthoangelol to DBH was calculated 0.52 <TEX>${mu}M$</TEX>. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The <TEX>$IC_{50}$</TEX> value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 <TEX>${mu}M$</TEX> and this value was higher than that of deprenyl (0.046 <TEX>${mu}M$</TEX>) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The <TEX>$IC_{50}$</TEX> value of cynaroside to DBH was calculated at 0.0410 <TEX>${mu}M$</TEX>. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect." @default.
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- W2089137138 date "2013-05-31" @default.
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- W2089137138 title "Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K" @default.
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- W2089137138 doi "https://doi.org/10.4062/biomolther.2012.100" @default.
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