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• W2089146926 abstract "The interesting study by Younossi et al.1 demonstrates that patients with chronic hepatitis C (CHC) are at increased risk of both liver-related mortality and overall mortality, and this risk increased in CHC patients who consume alcohol excessively (20 g/day or greater). Several studies have been focused on CHC patients consuming alcohol, analysing viral replication, therapeutic response or liver damage.2-10 We studied the prevalence of lesions compatible with alcohol intake (LCAI) in liver biopsies obtained from 62 CHC patients treated 48 weeks with pegylated interferon (PEG-IFN) plus ribavarin (RBV). All 62 patients (49 males, 79%), consumed at least two glasses of red wine daily (<20 g/day) and had a pre-treatment liver biopsy. LCAI scoring: steatosis, Mallory bodies, megamitochondries, polymorphonuclear infiltrate, perivessel fibrosis and siderosis; parameters scored as: 0: none, 1: mild, 2: medium, 3: moderate and 4: severe. Biopsies were evaluated (METAVIR) by a single expert pathologist. Biochemical and virological data were also assessed. Lesions compatible with alcohol intake were detected in 54/62 patients (87%): 46 steatosis, 3 megamitochondries, 2 Mallory bodies, 41 polymorphonuclear, 42 perivessel fibrosis, and 28 siderosis. Patients with LCAI (n = 54) demonstrated higher gamma-GT levels than those without (n = 8): 72 ± 51 vs. 34 ± 33 U/L, respectively (P < 0.05). No differences were found regarding viraemia (1 024 629 ± 916 092 vs. 748 750 ± 415 982 IU/mL, respectively; P = 0.4), AST (74 ± 47 vs. 63 ± 71 U/L, respectively; P = 0.5) or ALT (124 ± 93 vs. 121 ± 133 U/L, respectively; P = 0.9). Patients with LCAI showed more advanced fibrosis (F3-F4), not reaching statistical significance (37% vs. 25%; P = 0.7). All patients completed therapy and follow-up period: the global sustained virological response rate was 46.8% (29/62), in the LCAI group 46.3% and 50% in the non-LCAI group (Table 1). In summary, a high prevalence of LCAI was found in CHC patients consuming moderate amounts of red wine. LCAI were associated with higher serum gamma-GT levels and these patients had increased hepatic fibrogenesis. Noticeably, the presence of LCAI did not predict a worse therapeutic response to PEG-IFN plus RBV. Declaration of personal and funding interests: None." @default.
• W2089146926 created "2016-06-24" @default.
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• W2089146926 date "2013-05-09" @default.
• W2089146926 modified "2023-10-17" @default.
• W2089146926 title "Letter: impact of mild alcohol consumption in chronic hepatitis C treatment" @default.
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• W2089146926 doi "https://doi.org/10.1111/apt.12321" @default.
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