Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089148983> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2089148983 abstract "Abstracts: Frontiers in Cancer Prevention Research 2008B127 The incidence of testicular germ cell carcinoma (TGCC), the most common malignancy among men aged 20-34, has increased several-fold during the past several decades. The etiology of TGCC is poorly understood and the cause of the increased incidence is unknown. Established risk factors include age, race, personal history of undescended testes, and family history of TGCC, none of which is modifiable.Alcohol is an established testicular toxicant, causing testicular atrophy, gynecomastia, and disrupted sexual function in alcoholic men. In both alcoholics and non-alcoholic men with moderate intake, alcohol depresses levels of circulating testosterone and luteinizing hormone. We hypothesized that alcohol consumption, particularly during adolescence, increases the risk of TGCC. A single previous epidemiologic analysis of alcohol intake and TGCC found no association.We conducted a population-based case-control study among 18-44 year-old male residents of three Washington State counties. Cases (n=400) were diagnosed during 1999-2006 with a first, primary TGCC. Controls (n=1,020) were men of similar age with no history of TGCC from the same population identified through random-digit telephone dialing. Questionnaires elicited information on demographic, medical, and lifestyle factors, including usual consumption of beer, wine, and liquor during the 5 years prior to reference date and during grades 7-12. We used logistic regression models to compute odds ratio (OR) estimates and 95% confidence intervals (CI) for TGCC in men that consumed 1-6, 7-13, and 14+ alcoholic beverages per week compared to those that consumed none, adjusting for age, education, smoking, and current marijuana use.A higher proportion of cases than controls (73% vs. 66%) reported drinking 1 or more alcoholic beverages per week during the five years prior to reference date, and during grades 9-12 (44% vs. 37%). Consumption of 14+ alcoholic drinks/week was associated with an approximately 60% increased risk of TGCC (OR=1.62; 95% CI: 1.02-2.58) for consumption during the 5 years prior to reference date, and for consumption during grades 9-12 (OR=1.56; 95% CI: 0.99-2.47). The risk of TGCC appeared to be similar for consumption of beer, wine, or liquor, and for consumption of alcoholic beverages during adolescence versus consumption during adulthood. The risk of TGCC associated with 14+ alcoholic drinks/week was higher among men diagnosed with nonseminomas (OR=2.28; 95% CI: 1.08-4.82) than among men diagnosed with seminomas (OR=1.40 95%CI: 0.80-2.42).Our results indicate that consumption of 14 or more alcoholic beverages per week during adolescence or adulthood may be associated with a doubling of the risk of non-seminomatous TGCC. This is the first study to report an association between alcohol consumption and an increased risk of TGCC. Additional studies are needed to clarify the relationship between alcohol intake and TGCC.Citation Information: Cancer Prev Res 2008;1(7 Suppl):B127." @default.
- W2089148983 created "2016-06-24" @default.
- W2089148983 creator A5010510938 @default.
- W2089148983 creator A5026281051 @default.
- W2089148983 creator A5033491530 @default.
- W2089148983 creator A5052518234 @default.
- W2089148983 date "2008-11-01" @default.
- W2089148983 modified "2023-10-01" @default.
- W2089148983 title "Abstract B127: Alcohol consumption and risk of testicular germ cell carcinoma" @default.
- W2089148983 doi "https://doi.org/10.1158/1940-6207.prev-08-b127" @default.
- W2089148983 hasPublicationYear "2008" @default.
- W2089148983 type Work @default.
- W2089148983 sameAs 2089148983 @default.
- W2089148983 citedByCount "0" @default.
- W2089148983 crossrefType "proceedings-article" @default.
- W2089148983 hasAuthorship W2089148983A5010510938 @default.
- W2089148983 hasAuthorship W2089148983A5026281051 @default.
- W2089148983 hasAuthorship W2089148983A5033491530 @default.
- W2089148983 hasAuthorship W2089148983A5052518234 @default.
- W2089148983 hasConcept C120665830 @default.
- W2089148983 hasConcept C121332964 @default.
- W2089148983 hasConcept C121608353 @default.
- W2089148983 hasConcept C126322002 @default.
- W2089148983 hasConcept C144024400 @default.
- W2089148983 hasConcept C149923435 @default.
- W2089148983 hasConcept C156957248 @default.
- W2089148983 hasConcept C2776212926 @default.
- W2089148983 hasConcept C2908647359 @default.
- W2089148983 hasConcept C29456083 @default.
- W2089148983 hasConcept C61511704 @default.
- W2089148983 hasConcept C71924100 @default.
- W2089148983 hasConcept C99454951 @default.
- W2089148983 hasConceptScore W2089148983C120665830 @default.
- W2089148983 hasConceptScore W2089148983C121332964 @default.
- W2089148983 hasConceptScore W2089148983C121608353 @default.
- W2089148983 hasConceptScore W2089148983C126322002 @default.
- W2089148983 hasConceptScore W2089148983C144024400 @default.
- W2089148983 hasConceptScore W2089148983C149923435 @default.
- W2089148983 hasConceptScore W2089148983C156957248 @default.
- W2089148983 hasConceptScore W2089148983C2776212926 @default.
- W2089148983 hasConceptScore W2089148983C2908647359 @default.
- W2089148983 hasConceptScore W2089148983C29456083 @default.
- W2089148983 hasConceptScore W2089148983C61511704 @default.
- W2089148983 hasConceptScore W2089148983C71924100 @default.
- W2089148983 hasConceptScore W2089148983C99454951 @default.
- W2089148983 hasLocation W20891489831 @default.
- W2089148983 hasOpenAccess W2089148983 @default.
- W2089148983 hasPrimaryLocation W20891489831 @default.
- W2089148983 hasRelatedWork W169651853 @default.
- W2089148983 hasRelatedWork W1852691788 @default.
- W2089148983 hasRelatedWork W1972759053 @default.
- W2089148983 hasRelatedWork W1974058299 @default.
- W2089148983 hasRelatedWork W2001652757 @default.
- W2089148983 hasRelatedWork W2006394997 @default.
- W2089148983 hasRelatedWork W2032163472 @default.
- W2089148983 hasRelatedWork W2057486848 @default.
- W2089148983 hasRelatedWork W2066020877 @default.
- W2089148983 hasRelatedWork W2068754253 @default.
- W2089148983 hasRelatedWork W2119891059 @default.
- W2089148983 hasRelatedWork W2186688336 @default.
- W2089148983 hasRelatedWork W2261290365 @default.
- W2089148983 hasRelatedWork W2293467344 @default.
- W2089148983 hasRelatedWork W2313796903 @default.
- W2089148983 hasRelatedWork W2320980736 @default.
- W2089148983 hasRelatedWork W2413734177 @default.
- W2089148983 hasRelatedWork W2521934845 @default.
- W2089148983 hasRelatedWork W2754770806 @default.
- W2089148983 hasRelatedWork W2976950151 @default.
- W2089148983 isParatext "false" @default.
- W2089148983 isRetracted "false" @default.
- W2089148983 magId "2089148983" @default.
- W2089148983 workType "article" @default.