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• W2089155542 abstract "Huntington's disease is currently incurable, but cell therapy is seen as a promising alternative treatment. We analyze the safety and efficacy of the intrastriatal transplantation of human fetal neuroblasts from ganglionic eminences in patients with Huntington's disease. A few rare surgical incidents were reported, but the main difficulty associated with this therapeutic approach is the occurrence of recipient alloimmunization against the graft and the lack of availability, standardization and quality control for the fetus-derived products required for cell therapy. Some patients showed sustained cognitive improvement over periods of more than six years, and motor improvements for more than four years. Grafting outcomes are variable even within individual transplantation centers. The reasons for this variability are poorly understood, highlighting the need for further research in this specific area. With the perspective of additional trials in the future, we review here the development of human pluripotent stem cell-derived cell therapy products for HD, and their advantages and disadvantages with respect to fetal cells. La maladie de Huntington est une maladie grave incurable pour laquelle la thérapie cellulaire est une alternative thérapeutique prometteuse. Nous analysons ici, sous l’angle de la sécurité et de l’efficacité, les résultats des études réalisées chez les patients utilisant la greffe de neurones fœtaux humains. Outre les rares incidents chirurgicaux, le principal problème rencontré par la technique est celui de l’existence d’une allo-immunisation de l’hôte contre la greffe et du manque de disponibilité de cellules fœtales. Certains patients montrent une amélioration durable au-delà de 6 ans sur le plan cognitif et d’environ 4 ans voire plus sur le plan moteur. La variabilité des résultats y compris au sein d’un même centre impose de poursuivre la recherche fondamentale dans ce domaine. Dans la perspective de futurs essais, le développement des cellules souches pluripotentes et leurs avantages par rapport aux cellules fœtales sont décrits dans cette revue." @default.
• W2089155542 created "2016-06-24" @default.
• W2089155542 creator A5059115258 @default.
• W2089155542 creator A5079111889 @default.
• W2089155542 date "2014-12-01" @default.
• W2089155542 modified "2023-10-03" @default.
• W2089155542 title "Regenerative medicine in Huntington's disease: Current status on fetal grafts and prospects for the use of pluripotent stem cell" @default.
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• W2089155542 doi "https://doi.org/10.1016/j.neurol.2014.10.007" @default.
• W2089155542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25459124" @default.
• W2089155542 hasPublicationYear "2014" @default.

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