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• W2089163906 abstract "<b><i>Objective:</i></b> To obtain prospective data regarding seizures, anxiety, depression, and quality of life (QOL) outcomes after resective epilepsy surgery. <b><i>Methods:</i></b> The authors characterized resective epilepsy surgery patients prospectively at yearly intervals for seizure outcome, QOL, anxiety, and depression, using standardized instruments and patient interviews. <b><i>Results:</i></b> Of 396 patients who underwent resective surgical procedures, 355 were followed for at least 1 year. Of these, 75% achieved a 1-year remission at some time during follow-up; patients with medial temporal (77%) were more likely than neocortical resections (56%) to achieve remission (<i>p</i> = 0.01). Relapse occurred in 59 (22%) patients who remitted, more often in medial temporal (24%) than neocortical (4%) resected patients (<i>p</i> = 0.02). QOL, anxiety, and depression all improved dramatically within 3 months after surgery (<i>p</i> < 0.0001), with no significant difference based on seizure outcome. After 3 months, QOL in seizure-free patients further improved gradually, and patients with seizures showed gradual declines. By 12 and 24 months, overall QOL and its epilepsy-targeted and physical health domains were significantly different in the two outcome groups. (Anxiety and depression scores also gradually diverged, with improvements in seizure-free and declines in continued seizure groups, but differences were not significant.) <b><i>Conclusion:</i></b> Resective surgery for treatment of epilepsy significantly reduces seizures, most strikingly after medial temporal resection (77% 1 year remission) compared to neocortical resection (56% 1 year remission). Resective epilepsy surgery has a gradual but lasting effect on QOL, but minimal effects on anxiety and depression. Longer follow-up will be essential to determine ultimate seizure, QOL, and psychiatric outcomes of epilepsy surgery." @default.
• W2089163906 created "2016-06-24" @default.
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• W2089163906 date "2003-12-22" @default.
• W2089163906 modified "2023-10-16" @default.
• W2089163906 title "Initial outcomes in the Multicenter Study of Epilepsy Surgery" @default.
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• W2089163906 doi "https://doi.org/10.1212/01.wnl.0000098937.35486.a3" @default.
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